Effects of Vitamin C and E Combination on Element and Oxidative Stress Levels in the Blood of Operative Patients Under Desflurane Anesthesia

Abstract

We investigated effects of vitamin C and E (VCE) administration on desflurane-induced oxidative toxicity and element changes in the blood of operative patients under desflurane general anesthesia. Forty American Society of Anesthesiologists I or II Physical Status adult patients were scheduled for elective surgery. The patients were randomly divided into two groups. Control and VCE group was introduced to anesthesia with desflurane. VCE was administreted to patients in the control and VCE group before 1 hour of anesthesia with desflurane. Baseline (preoperative) and postoperative (at the 1(st), the 24(th), and 72(th) h), blood samples were taken from the first and second groups. Erythrocyte and plasma lipid peroxidation levels at the 1(st), 24(th), and 72(th) hours were higher in the control than in baseline group, although their levels at the same periods were lower in the VCE group than in the control. Vitamin E levels at the postoperative 1(st) and 24(th) hours and erythrocyte glutathione peroxidase (GSH-Px) activity at the postoperative 1(st), 24(th), and 72(th) hours was lower than in baseline values. Erythrocyte GSH-Px activity and plasma vitamins A, C, and E levels at the postoperative 1(st), 24(th), and 72(th) hours were higher in the VCE group than in the control group. Erythrocyte and plasma reduced glutathione, plasma β-carotene, and serum copper, while zinc, selenium, aluminum, iron, magnesium, and calcium levels did not differ between preoperative and postoperative periods in both groups. In conclusion, VCE combination prevented the desflurane-induced vitamin E and GSH-Px consumptions to strengthen the antioxidant levels in the blood of operative patients.

Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial

“…At 72 h following the administration of desflurane general anesthesia, plasma lipid peroxidation levels were higher and vitamin C remained unaltered in operative patients who did not receive vitamin C and vitamin E before surgery than in those who received these vitamins [36]. In our patients, MDA and free 8-isoprostane concentrations did not change along chemotherapy, and zinc supplementation did not affect the plasma concentrations of these lipid peroxidation markers.…”

Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy

“…Administration of vitamin E has been reported to have an important protective effect against chemotherapy‐induced peripheral nerve damage 29 . In addition, vitamins E and C in combination, have been reported to reduce the oxidative damage induced by certain anesthetic drugs 30 and exercise 31 . In the present study, we found that VCE supplementation markedly increased ( P < 0·01) the levels of all free radical scavenging enzymes, SOD, CAT, GST and GR (Table 2) as well as of the non‐enzymatic antioxidant, GSH (Fig.…”

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

“…3 MDA results from the breakdown of lipid peroxyl radicals and oxidizes protein molecules, and thus, it is both an indicator and effector of oxidative stress. 3 MDA results from the breakdown of lipid peroxyl radicals and oxidizes protein molecules, and thus, it is both an indicator and effector of oxidative stress.…”

“…The concentrations of these metabolites are kept under a precise control. 3 ROS are scavenged by antioxidant defence systems including enzymes and non-enzyme species such as vitamin C, vitamin E, vitamin A, b-carotene, glutathione peroxidase (GSH-Px) and reduced glutathione (GSH). 2 Also, recent studies have shown that ROS mediated oxidative stress can cause cellular damage.…”

“…2 Also, recent studies have shown that ROS mediated oxidative stress can cause cellular damage. 3 ROS are scavenged by antioxidant defence systems including enzymes and non-enzyme species such as vitamin C, vitamin E, vitamin A, b-carotene, glutathione peroxidase (GSH-Px) and reduced glutathione (GSH). 1 Vitamin C protects lipids from detectable oxidation and is effective against the oxidants released from activated polymorphonuclear leukocytes.…”