Effects of vitamin D receptor gene polymorphism and clinical characteristics on risk of diabetic retinopathy in Han Chinese type 2 diabetes patients

Zhong, Xing; Du, Yiqi; Yuan, Ling; Liu, Nina; Guo, Yongxian; Pan, Tianrong

doi:10.1016/j.gene.2015.04.045

Cited by 40 publications

(34 citation statements)

References 34 publications

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“…One article was excluded for departure from HWE in the control group [13]. Finally, 7 eligible studies (649 cases and 707 controls) published from 2002 to 2015 were included in this meta-analysis [14–20], and the data was extracted. The study selection procedure was shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 7 studies, 6 studies focused on the association of DR risk and FokI polymorphism [14–19], 3 on TaqI polymorphism [17, 18, 20], 3 on BsmI polymorphism [14, 17, 18], and 2 on ApaI polymorphism [14, 18]. All the polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 4 studies included Caucasian populations [17–20], and 3 included Asian populations [14–16]. Four studies were conducted in type 2 diabetes patients [14–16, 18] and 3 in type 1 diabetes patients [17, 19, 20]. The study characteristics were displayed in Table 1, and the genotype distributions of all studies are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

Zhang

Xia

Lü

et al. 2016

BioMed Research International

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Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic. Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls). Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (OR = 1.612 (1.354~1.921), 1.988 (1.481~2.668), 1.889 (1.424~2.505), and 2.674 (1.493~4.790) in allelic, dominant, recessive, and additive models, resp., P Z < 0.01), but not for TaqI or BsmI polymorphism (P Z > 0.05). Similar results were found in the subgroup analysis. Sensitivity analysis indicated that the results were relatively stable and reliable. Results of Begg's and Egger's tests suggested a lack of publication bias. Conclusions. Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism. However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

Zhang

Xia

Lü

et al. 2016

BioMed Research International

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“…The mutant allele of FokI polymorphism was further found to be associated with the diabetes retinopathy in Han Chinese population [43]. According to the meta-analysis by Yu et al, the mutant allele and mutant homozygous (AA) of the BsmI polymorphism was also significantly associated with the T2DM [41].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms and Haplotype Analysis in Type 2 Diabetes Mellitus Patients From North India

Taneja

Khadgawat

Mani

2017

Asian J Pharm Clin Res

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Objective: Vitamin D receptor (VDR) mediated Vitamin D signaling is important for expression of insulin gene and glucose transporters, which help in glucose uptake by cells. Current evidence suggests that four common polymorphisms (FokI, BsmI, ApaI, TaqI) of VDR gene are associated with Type 2 diabetes mellitus (T2DM) in different populations. However, there is a scarcity of data on VDR polymorphisms from Indian population.Methods: In the current study, total genomic DNA was isolated from 100 well-characterized T2DM patients and 100 healthy controls. We investigated the prevalence of FokI and ApaI polymorphisms in VDR gene of these patients by polymerase chain reaction-restriction fragment length polymorphismbased method. Taking help of our previous published data on TaqI and BsmI polymorphisms in same patients, the haplotype study was also conducted. Statistical analysis of data was performed using SPSS 21.0 software. Haplotype and linkage disequilibrium analysis was performed by Haploview software.Results: Both the wild (TT) and mutant (CC) genotype of FokI polymorphism showed a significant difference between patients and controls (p<0.001 and p<0.001, respectively). The frequency of mutant allele (C) was also significantly higher in T2DM patients than the controls (p<0.001). In case of ApaI, frequency of wild (GG) and mutant (CC) genotype was significantly different in patients and controls (p=0.017 and p=0.034). As per haplotype analysis, the CACT haplotype was predicted to be of significance in patients and consists of mutant alleles of three polymorphisms (FokI, BsmI, ApaI). Conclusion:Our study supports the association of FokI and ApaI polymorphism in T2DM. The haplotype analysis also indicates that the combinations of mutant allele of different VDR polymorphisms are probably responsible for increased susceptibility of these individuals toward T2DM.

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“…Vitamin D receptor-related genotypes have been associated with diabetic retinopathy in type 1 and type 2 diabetic subjects [249][250][251][252][253][254]. Similar to its known role in bone and calcium metabolism, vitamin D also has roles in insulin resistance and immune function, and it has anti-inflammatory, anti-angiogenic, and anti-fibrotic effects.…”

Section: Nutrition-related Biomarkersmentioning

confidence: 99%

Biomarkers in Diabetic Retinopathy

et al. 2015

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■ AbstractThere is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which is not related to adiposity. Whilst improved diabetes care has substantially improved diabetes outcomes, the disease remains a common cause of working age adult-onset blindness. Diabetic retinopathy is the most frequently occurring complication of diabetes; it is greatly feared by many diabetes patients. There are multiple risk factors and markers for the onset and progression of diabetic retinopathy, yet residual risk remains. Screening for diabetic retinopathy is recommended to facilitate early detection and treatment. Common biomarkers of diabetic retinopathy and its risk in clinical practice today relate to the visualization of the retinal vasculature and measures of glycemia, lipids, blood pressure, body weight, smoking, and pregnancy status. Greater knowledge of novel biomarkers and mediators of diabetic retinopathy, such as those related to inflammation and angiogenesis, has contributed to the development of additional therapeutics, in particular for late-stage retinopathy, including intra-ocular corticosteroids and intravitreal vascular endothelial growth factor inhibitors ('anti-VEGFs') agents. Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics. Therefore, more effective treatments for diabetic retinopathy are necessary. New analytical techniques, in particular those related to molecular markers, are accelerating progress in diabetic retinopathy research. Given the increasing incidence and prevalence of diabetes, and the limited capacity of healthcare systems to screen and treat diabetic retinopathy, there is need to reliably identify and triage people with diabetes. Biomarkers may facilitate a better understanding of diabetic retinopathy, and contribute to the development of novel treatments and new clinical strategies to prevent vision loss in people with diabetes. This article reviews key aspects related to biomarker research, and focuses on some specific biomarkers relevant to diabetic retinopathy.

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Effects of vitamin D receptor gene polymorphism and clinical characteristics on risk of diabetic retinopathy in Han Chinese type 2 diabetes patients

Cited by 40 publications

References 34 publications

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

Vitamin D Receptor Gene Polymorphisms and Haplotype Analysis in Type 2 Diabetes Mellitus Patients From North India

Biomarkers in Diabetic Retinopathy

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