Effects of Vitamin E and Glutathione on Glucose Metabolism

Barbagallo, Mario; Domínguez, Ligia J.; Tagliamonte, Maria; Resnick, Lawrence M.; Paolisso, Giuseppe

doi:10.1161/01.hyp.34.4.1002

Cited by 106 publications

(71 citation statements)

References 37 publications

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“…The antioxidant activity is normalized in group II but it worsens in group I so diabetic patients may have elevated requirement for antioxidants. Vitamin E supplementation increases cellular GSH concentration by sparing action [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation

2010

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Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications. The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls. Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels. The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II, those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation

2010

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“…In fact, Mg deficiency has been associated with production of ROS [67] . Additionally, Mg protects cells against oxyradical damage and assists in the absorption and metabolism of vitamins B, C and E [68] , which are antioxidants important in cellular protection. Recent evidence suggests that vitamin E enhances glutathione levels and may play a protective role in Mg deficiencyinduced cardiac lesions [68] .…”

Section: Discussionmentioning

confidence: 99%

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum chloride (AlCl 3 ) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: a control group treated with normal saline, the AlCl 3 -treated group and the camel's milk-AlCl 3 -treated group. The AlCl 3 treated group received 0.5 mg kg −1 of AlCl 3 orally. The camel's milk-AlCl 3 -treated group was fed 1 mL of fresh camel's milk 10 minutes prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Liver and kidney biochemical serum parameters were analyzed. Lipid peroxidation, as determined by the tissue concentrations of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP), and the oxidative stress status, as measured by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity, were evaluated in the kidney and liver of treated rats. Results: Data showed that the oral administration of AlCl 3 resulted in statistically significant increases in the serum levels of urea, creatinine, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol and triglycerides; the total amount of protein and albumin were also significantly decreased. However, these parameters were within normal levels in the rats given camel's milk prior to AlCl 3 . Additionally, oral administration of AlCl 3 induced lipid peroxidation in the liver and kidney, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the activities of GSH, SOD and CAT. In all rats treated with camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were within normal levels. Conclusion: Treatment with camel's milk prior to AlCl 3 exposure alleviates AlCl 3 -associated hazards and protects the kidney and liver from AlCl 3 toxicity.

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“…Magnesium deficiency (MgD) has been associated with production of reactive oxygen species [66] . Magnesium protects the cell against oxyradical damage and assists in the absorption and metabolism of B vitamins, vitamin C and E [67] , which are antioxidants important in cell protection. Recent evidence suggests that vitamin E enhances glutathione levels and may play a protective role in magnesium deficiency-induced cardiac lesions [67] .…”

Section: Discussionmentioning

confidence: 99%

“…Magnesium protects the cell against oxyradical damage and assists in the absorption and metabolism of B vitamins, vitamin C and E [67] , which are antioxidants important in cell protection. Recent evidence suggests that vitamin E enhances glutathione levels and may play a protective role in magnesium deficiency-induced cardiac lesions [67] . Also it has been reported that magnesium is very essential for biosynthesis of glutathione, because the enzyme Glutathione synthetase requires γ-glutamyl cysteine, glycine, ATP and magnesium ions to form glutathione [68] .…”

Section: Discussionmentioning

confidence: 99%

Camel's Milk Protects Against Cadmium Chloride Induced Toxicity in White Albino Rats

Al‐Hashem¹,

Dallak²,

Bashir³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement:Cadmium is one of the most dangerous occupational and environmental toxins. It is found in drinking water, atmospheric air and even in food. Cadmium is reported to be very toxic to biological systems. Until now in treating intoxication with this metal, chelating Compounds have been used, burdened with numerous undesirable symptoms. For this reason, many researches are carried out in many countries to find natural-made compounds that help in the protection against cadmium induced toxicity with fewer or no side effects. This study was conducted to demonstrate the effect of daily oral Camel's milk administration against Cadmium chloride induced toxicity in white albino rats. Approach: White albino rats of both sexes (230-250 g) were housed in standard metal cages (6 rats/cage). The experimental rats (6 in each group) distributed into two experimental groups with a shared control group received only normal saline orally (Group 1). In experimental first group a daily dose (10 mg kg  1 body weight) of cadmium chloride was orally administrated to the rats for 21 days and named Cadmium chloride treated rats. In experimental second group, the same concentrations of cadmium chloride was dissolved in 2 mL of early morning fresh Camel's milk and the whole solution was administered into the experimental rats for 21 days and named Camel's milk cadmium chloride treated group. Water and food were provided ad libitum. Results: The data indicated that, in experimental Cadmium chloride treated rats, serum albumin, calcium and blood hemoglobin were decreased compared with control group received normal saline only. Moreover, Camel's milk administration with cadmium chloride showed a significant improvement of albumin, hemoglobin and calcium levels in the serum of the rats compared with cadmium chloride treated rats. Serum iron, sodium, chloride and urea levels were significantly increased in cadmium chloride treated rats compared with control group, while the addition of camel's milk to cadmium chloride decreased the high levels of these serum parameters in the treated rats. The enzyme activities of serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and serum Alkaline Phaospatase (ALP) were significantly increased by orally administration of cadmium chloride compared with control group, while adding Camel's milk to cadmium chloride decreased the high levels of these enzymes comparing with the cadmium chloride treated rats. Cadmium chloride administration resulted in a high concentration of lipid peroxidation markers; TBARS and Hydroperoxides in comparison to control group, adding camel's milk to the cadmium chloride restored the levels of these markers to their normal levels in comparing to Cadmium chloride treated rats. Also treatment with cadmium chloride alone caused a significant decrease in both the enzymatic and nonenzymatic markers of oxidative stress (superoxide dismutase and catalase) and reduced glutathione, respectively in the liver tissues of treated rats, while the admini...

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Effects of Vitamin E and Glutathione on Glucose Metabolism

Cited by 106 publications

References 37 publications

Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation

Evaluation of Oxidative Stress in Type 2 Diabetes Mellitus and Follow-up Along with Vitamin E Supplementation

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Camel's Milk Protects Against Cadmium Chloride Induced Toxicity in White Albino Rats

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