Effects of vitamin E on dolichol content of rats acutely treated with 1,2-dichloroethane

Cottalasso, Damiano; Bellocchio, Antonella; Norese, Raffaella; Domenicotti, Cinzia; Pronzato, Maria Adelaide; Fontana, Luigi; Nanni, Giorgio

doi:10.1016/s0300-483x(99)00181-x

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Cited by 7 publications

(2 citation statements)

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“…Total dolichol, which is present in all biological membranes, decreases early in liver pathology (Pronzato et al, 1990;Cottalasso et al, 2000). Dolichol is an isoprenoid lipid widely distributed within all biological membranes.…”

Section: Introductionmentioning

confidence: 99%

Effect of a load of Vitamin A after acute thioacetamide intoxication on dolichol, dolichol isoprenoids and retinol content in isolated rat liver cells

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Effect of a load of Vitamin A after acute thioacetamide intoxication on dolichol, dolichol isoprenoids and retinol content in isolated rat liver cells

et al. 2004

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“…Dolichol and dolichol-P have also been reported to occur in the Golgi [44][45][46]. Altered or impaired shuttling of these essential precursor lipids between the ER and Golgi could alter their distribution, thus limiting their availability in the ER.…”

Section: Type I Type Ii And…mentioning

confidence: 99%

Congenital Disorders of Glycosylation: CDG-I, CDG-II, and Beyond

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2007

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The Congenital Disorders of Glycosylation (CDG) are a collection of over 20 inherited diseases that impair protein N-glycosylation. The clinical appearance of CDG patients is quite diverse making it difficult for physicians to recognize them. A simple blood test of transferrin glycosylation status signals a glycosylation abnormality, but not the specific defect. An abnormal trasferrin glycosylation pattern suggests that the defect is in either genes that synthesize and add the precursor glycan (Glc(3)Man(9)GlcNAc(2)) to proteins (Type I) or genes that process the protein-bound N-glycans (Type II). Type I defects create unoccupied glycosylation sites, while Type II defects give fully occupied sites with abnormally processed glycans. These types are expected to be mutually exclusive, but a group of patients is now emerging who have variable coagulopathy and hypoglycemia together with a combination of Type I and Type II transferrin features. This surprising finding makes identifying their defects more challenging, but the defects and associated clinical manifestations of these patients suggest that the N-glycosylation pathway has some secrets left to share.

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Influence of chronic ethanol consumption on toxic effects of 1,2-dichloroethane: glycolipoprotein retention and impairment of dolichol concentration in rat liver microsomes and Golgi apparatus

et al. 2002

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Effects of vitamin E on dolichol content of rats acutely treated with 1,2-dichloroethane

Cited by 7 publications

References 34 publications

Effect of a load of Vitamin A after acute thioacetamide intoxication on dolichol, dolichol isoprenoids and retinol content in isolated rat liver cells

Effect of a load of Vitamin A after acute thioacetamide intoxication on dolichol, dolichol isoprenoids and retinol content in isolated rat liver cells

Congenital Disorders of Glycosylation: CDG-I, CDG-II, and Beyond

Influence of chronic ethanol consumption on toxic effects of 1,2-dichloroethane: glycolipoprotein retention and impairment of dolichol concentration in rat liver microsomes and Golgi apparatus

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