Effects of vitamin E supplementation on blood antioxidants levels in patients with Behçet’s disease

Kökçam, İbrahim; Nazıroğlu, Mustafa

doi:10.1016/s0009-9120(02)00400-9

Cited by 57 publications

(50 citation statements)

References 25 publications

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“…In a study of vitamin E supplementation in Behcet's disease, ASO, CRP, and ESR levels were significantly higher in the patient group than in the controls [21]. These data were similar to our results.…”

Section: Discussionsupporting

confidence: 91%

Antistreptolysin O Levels in Patients with Behcet’s Disease

Uzkeser¹,

Karatay²,

Yıldırım³

et al. 2011

EAJM

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Objective: Behcet's disease is a multisystem inflammatory disorder, and its etiology has not been defined clearly yet. In this study, we aimed to investigate the antistreptolysin O (ASO) levels of patients with Behcet's disease. Materials and Methods:Thirty patients with Behcet's disease and 30 healthy controls were enrolled in this study. We measured erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), and ASO levels in both groups.Results: There was no statistically significant difference between the two groups with respect to demographic data (p>0.05). The ASO levels of the patients and the controls were 288.4±145.7 and 170.6±142.4 ng/ml, respectively. In the patients with Behcet's disease, ASO (p<0.01) and ESR (p<0.05) values were significantly higher than in the healthy controls. There was no other significant difference in serum CRP levels between the patients and the controls. We could not find any correlation among ASO, CRP, and ESR values. Conclusion:Our results suggest that serum ASO levels may increase in patients with Behcet's disease. Further studies are needed in order to define the relationship between ASO levels and inflammation status in Behcet's disease. Sonuç: Bizim sonuçlarımıza göre Behçet hastalarında serum ASO seviyeleri yüksek olabilir. Behçet hastalarında ASO düzeyleri ve inflamasyon kaskadı arasındaki ilişkiyi belirlemek için yeni çalışmalara ihtiyaç duyulmaktadır.

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Section: Discussionsupporting

confidence: 91%

Antistreptolysin O Levels in Patients with Behcet’s Disease

Uzkeser¹,

Karatay²,

Yıldırım³

et al. 2011

EAJM

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“…6,21 Decreased activity of GPx in the surrounding tissues of the stainless steel, ceramic and titanium groups may be due to decreased GSH formation which requires NADPH and GR. 5,21 NADPH is required for the reduction of oxidized glutathione and protein sulfhydryl groups.…”

Section: 20mentioning

confidence: 99%

“…3,4 ROS have been implicated as mediators of tissue damage in patients with tissue degeneration such as rheumatoid arthritis and inflammatory skin diseases. 5,6 ROS are formed in oxidative processes that normally occur at relatively low levels in all cells and tissues. Under normal conditions, a variety of antioxidant mechanisms serve to control this ROS production.…”

Section: Introductionmentioning

confidence: 99%

“…Under normal conditions, a variety of antioxidant mechanisms serve to control this ROS production. 6,7 In contrast, high doses and/or inadequate removal of ROS result in oxidative stress, which may cause severe metabolic malfunctions and damage to biological macromolecules. 5 Elevated levels of lipid peroxidation (LP) have been observed in human fibroblast cultures with acrylic bone cement.…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of antioxidant enzymes in tissues surrounding implant in rabbits

Özmen¹,

Nazıroğlu²,

Okutan³

2006

Cell Biochem. Funct.

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There is a possible role of reactive oxygen species (SROS) in the complication of implants although there is presently little information. The aim of this study was to investigate the alterations in lipid peroxidation (LP) and antioxidant enzyme activities in tissues surrounding implants in rabbits. Thirty New Zealand albino male rabbits were used. They were randomly divided into five groups. The first group (I) was used as control. Groups II, III, IV and V were implanted with stainless steel, ceramic, titanium and polyethylene, respectively. One month after the administration of implant, the tissues surrounding the implant were carefully removed for antioxidant enzyme analysis. Glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GR), superoxide dismutases (SOD), glutathione peroxidase (GPx), catalase (CAT) in tissues surrounding the implants in the groups II, III and IV were significantly (p<0.05-p<0.001) lower than in the control group although glutathione S-transferase (GST) activities and LP values were increased. CAT activity and LP level did not decrease in group V. In conclusion, these data demonstrate that there is an increase in lipid peroxidation in the tissues surrounding ceramic and titanium implants of animals whereas there is a decrease in antioxidant enzymes. Oxidative stress plays a very important role in the complications of ceramic and titanium implants. The polyethylene implant seems to be the best of the four implant materials tested.

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“…11 Many researchers have focused on oxidative stress and increased tendency of RA patients to lipid peroxidation for the last few years. 3 Although various studies have been performed on antioxidant vitamins and enzymes in inflammatory diseases, 6,12,13 limited number of studies have focused on lipid peroxidation status and inflammatory parameters in patients with RA. Determination of the pathologic mechanism has a special importance in the early diagnosis and treatment of RA.…”

mentioning

confidence: 99%

Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

et al. 2016

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Objectives: This study aims to evaluate serum 4-hydroxynonenal (4-HNE) levels and its clinical and radiological significance in patients with rheumatoid arthritis (RA). Patients and methods:The study included 40 patients (8 males, 32 females; mean age 51.4±11.2 years; range 24 to 72 years) with RA and 30 healthy controls (8 males, 32 females; mean age 53.0±11.7 years; range 24 to 72 years. Serum 4-HNE levels were measured using sandwich enzyme-linked immunosorbent assay method. Patients with disease activity score 28 ≤3.2 and >3.2 were allocated into low and high/moderate disease activity groups, respectively. Additionally, patients were divided into two groups as early RA (disease duration ≤2 years) and established RA (disease duration ≥2 years). Functional disability was evaluated using health assessment questionnaire. Radiographs were scored using the modified Larsen scoring. Results: Serum 4-HNE levels in patients with RA were significantly higher than controls (p=0.001). Serum 4-HNE levels did not correlate with laboratory or clinical parameters of disease activity including erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, and health assessment questionnaire. Serum 4-HNE levels were higher in patients with established RA than patients with early RA (r=0.487, p=0.001). Besides, modified Larsen score which indicates structural damage correlated significantly with serum 4-HNE levels (p=0.001). Conclusion: These results indicate that serum 4-HNE levels may be used as an indicator for structural damage such as erosions in the early stage of RA; however, they are not efficient to monitor disease activity.

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Effects of vitamin E supplementation on blood antioxidants levels in patients with Behçet’s disease

Cited by 57 publications

References 25 publications

Antistreptolysin O Levels in Patients with Behcet’s Disease

Antistreptolysin O Levels in Patients with Behcet’s Disease

Comparative study of antioxidant enzymes in tissues surrounding implant in rabbits

Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

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