Effects of Vitamin K-Active Compounds and Intestinal Microorganisms in Vitamin K-Deficient Germfree Rats

Gustafsson, Bengt E.; Daft, Floyd S.; McDaniel, E. G.; Smith, James C.; Fitzgerald, Robert J.

doi:10.1093/jn/78.4.461

Cited by 89 publications

(26 citation statements)

References 13 publications

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“…For example, people treated with a broad-spectrum antibiotic showed a significant decrease in plasma prothrombin levels [75]. Germ-free but not the conventional animals fed a diet without vitamin K supplement have low prothrombin levels and develop hemorrhages [76]. …”

Section: Intestinal Microbiota and Gut Homeostasismentioning

confidence: 99%

Microbiota, Inflammation and Colorectal Cancer

Lucas

Barnich

Nguyen

2017

IJMS

265

134

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Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment.

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Section: Intestinal Microbiota and Gut Homeostasismentioning

confidence: 99%

Microbiota, Inflammation and Colorectal Cancer

Lucas

Barnich

Nguyen

2017

IJMS

265

134

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“…It has been suggested that vitamin K has an effect on growth although the evidence is somewhat conflicting. observed a depression in growth rate in the non-coprophagic rat in the absence of dietary vitamin K. Gustafsson, Daft, McDaniel, Smith & Fitzgerald (1962) could detect no difference in the body weights of germ-free rats fed on diets with and without vitamin K, until shortly before death of the deficient animals. A similar observation was recorded by Wostmann, Knight, Keeley & Kan (1963).…”

Section: Function Of Vitamin K In the Bodymentioning

confidence: 80%

“…If germ-free rats were fed a vitamin K-deficient diet and subsequently monoassociated with either Escherichia coli or a sacina-like organism, their prothrombin times returned to normal within 48 hours (Gustafsson et al, 1962). However, similar association with ten other types of bacteria isolated from rats had no effect.…”

Section: Microfloral Synthesismentioning

confidence: 99%

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Factors Influencing Dietary Vitamin K Requirements of Rats and Mice

Hacking

Lane-Petter

1968

Lab Anim

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SUMMARYThe literature concerning the dietary requirements of rats and mice for vitamin K has been reviewed and some relevant observations on the breeding colony of rats at Carworth Europe are reported. From the literature cited it is concluded that the true vitamin K requirement, that is, the amount that must be absorbed to prevent prolongation of prothrombin time, is influenced by many factors; the most important are strain, age, sex and environmental temperature. In determining the amount of a particular form of vitamin K that must be included in the diet of a given strain of rat or mouse in a given environment, the principal factors to be considered are the degree of coprophagy, the level of vitamin A and the amount and types of fats and proteins present in the diet.

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“…This may be the case for other staphylococci. It has been shown in experimentally induced vitamin K deficiency in germ-free rats that a single strain of vitamin K-producing bacteria may reverse the effects of the diet (13).…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic Cardiomyopathy and Hemothorax in Vitamin K Deficient Mice

Allen¹,

Hansen

Moore

et al. 1991

Toxicol Pathol

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The cause of a fatal condition characterized by hemorrhagic cardiomyopathy, hemothorax, and coagulation defects in hysterectomy-derived male mice was investigated. Microscopic heart alterations included multifocal hemorrhage and necrosis with variable degrees of acute inflammation and fibroplasia that were most severe in the region of the atrioventricular junction. A spontaneous outbreak was arrested by increasing menadione Na-bisulfite (vitamin K) in the feed to 20 ppm. The complete syndrome including hemorrhagic cardiomyopathy was readily reproduced in germ-free male mice given a vitamin K-free diet, and in conventional male and female mice given Warfarin in the diet. We concluded that the cause of this condition was vitamin K deficiency.

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Effects of Vitamin K-Active Compounds and Intestinal Microorganisms in Vitamin K-Deficient Germfree Rats

Cited by 89 publications

References 13 publications

Microbiota, Inflammation and Colorectal Cancer

Microbiota, Inflammation and Colorectal Cancer

Factors Influencing Dietary Vitamin K Requirements of Rats and Mice

Hemorrhagic Cardiomyopathy and Hemothorax in Vitamin K Deficient Mice

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