Effects of voluntary exercise on anxiety-like behavior and voluntary morphine consumption in rat pups borne from morphine-dependent mothers during pregnancy

Haydari, Sakineh; Miladi‐Gorji, Hossein; Mokhtari, Amin; Safari, Manouchehr

doi:10.1016/j.neulet.2014.06.026

Cited by 29 publications

(19 citation statements)

References 26 publications

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“…In fact, in some mice pain models, it is demonstrated that diazepam has no effect on pain behaviors in different drug doses [ 15 , 29 ]. On the other hand, as a classical analgesic drug, morphine has potent anti-anxiety effects in animals [ 15 , 41 , 42 ], implying that inhibition of pain behaviors is likely able to prevent the development of anxiety. Taken together, we suggest that the nerve injury-evoked anxiety-like behaviors are pain related.…”

Section: Discussionmentioning

confidence: 99%

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

et al. 2014

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BackgroundDespite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related anxiety are largely unknown. With its well-documented role in pain and emotion processing, the amygdala may act as a key player in pathogenesis of neuropathic pain-related anxiety. Pain-related plasticity and sensitization of CeA (central nucleus of the amygdala) neurons have been shown in several models of chronic pain. In addition, firing pattern of neurons with spike output can powerfully affect functional output of the brain nucleus, and GABAergic neurons are crucial in the modulation of neuronal excitability. In this study, we first investigated whether pain-related plasticity (e.g. alteration of neuronal firing patterns) and sensitization of CeA neurons contribute to nerve injury-evoked anxiety in neuropathic rats. Furthermore, we explored whether GABAergic disinhibition is responsible for regulating firing patterns and intrinsic excitabilities of CeA neurons as well as for pain-related anxiety in neuropathic rats.ResultsWe discovered that spinal nerve ligation (SNL) produced neuropathic pain-related anxiety-like behaviors in rats, which could be specifically inhibited by intra-CeA administration of anti-anxiety drug diazepam. Moreover, we found potentiated plasticity and sensitization of CeA neurons in SNL-induced anxiety rats, of which including: 1) increased burst firing pattern and early-adapting firing pattern; 2) increased spike frequency and intrinsic excitability; 3) increased amplitude of both after-depolarized-potential (ADP) and sub-threshold membrane potential oscillation. In addition, we observed a remarkable reduction of GABAergic inhibition in CeA neurons in SNL-induced anxiety rats, which was proved to be important for altered firing patterns and hyperexcitability of CeA neurons, thereby greatly contributing to the development of neuropathic pain-related anxiety. Accordantly, activation of GABAergic inhibition by intra-CeA administration of muscimol, a selective GABAA receptors agonist, could inhibit SNL-induced anxiety-like behaviors in neuropathic rats. By contrast, suppression of GABAergic inhibition by intra-CeA administration of bicuculline, a selective GABAA receptors antagonist, produced anxiety-like behavior in normal rats.ConclusionsThis study suggests that reduction of GABAergic inhibition may be responsible for potentiated plasticity and sensitization of CeA neurons, which likely underlie the enhanced output of amygdala and neuropathic pain-related anxiety in SNL rats.Electronic supplementary materialThe online version of this article (doi:10.1186/s13041-014-0072-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

et al. 2014

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“…Linking brain cellular pathophysiology with symptoms of human opioid use disorder (OUD) requires preclinical animal models that mimic behavioral phenotypes observed in humans with OUD. For example, rats receiving long-term noncontingent administration of opioids exhibit deficits in learning and memory tasks (13)(14)(15)(16), and opioid use and abstinence in rodents involves development of social withdrawal (17), anxietylike and depression-like behaviors (18,19), vulnerability to stressors (20), and decreased motivation for natural rewards (21), similar to symptoms observed in OUD (3,4,(22)(23)(24)(25)(26). In selfadministration models of OUD, rodents perform operant tasks to receive intravenous opioid infusions, often paired with a conditioning stimulus (cue).…”

Section: Preclinical Models Of Opioid Addictionmentioning

confidence: 99%

The Opioid-Addicted Tetrapartite Synapse

Kruyer¹,

Chioma²,

Kalivas

2020

Biological Psychiatry

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Opioid administration in preclinical models induces long-lasting adaptations in reward and habit circuitry. The latest research demonstrates that in the nucleus accumbens, opioid-induced excitatory synaptic plasticity involves presynaptic and postsynaptic elements as well as adjacent astroglial processes and the perisynaptic extracellular matrix. We outline opioid-induced modifications within each component of the tetrapartite synapse and provide a neurobiological perspective on how these adaptations converge to produce addiction-related behaviors in rodent models. By incorporating changes observed at each of the excitatory synaptic compartments into a unified framework of opioid-induced glutamate dysregulation, we highlight new avenues for restoring synaptic homeostasis that might limit opioid craving and relapse vulnerability.

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“…Clark et al (1995) showed that mice of 12 different strains that exercised in running wheels display increased neurogenesis in the hippocampus, a brain area involved in cognition and emotionality (Bannerman et al, 2004;Juruena et al, 2004;Kalisch et al, 2006). Moreover, 14 to 21 days of PE in running wheels have been shown to improve attention of male and female SHR rats (Robinson et al, 2011) and have been suggested to be effective in decreasing anxiety symptoms (Haydari et al, 2014). However, caution is needed because increased activity or locomotion could also be considered as a stress response to a new environment (Thorsell et al, 2006;Ago et al, 2007;Malisch et al, 2016).…”

Section: 5 Discussion -Experimentsmentioning

confidence: 99%

Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains

Mazur

Oliveira

Cunha

et al. 2017

Behavioural Processes

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Effects of voluntary exercise on anxiety-like behavior and voluntary morphine consumption in rat pups borne from morphine-dependent mothers during pregnancy

Cited by 29 publications

References 26 publications

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

The Opioid-Addicted Tetrapartite Synapse

Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains

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