Effects of Vomeronasal Organ Removal on the Sperm Motility in Male Mice

Koyama, Sachiko; Kamimura, Shinji

doi:10.2108/zsj.20.1355

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…We also found that these pheromones do not have detectable effects on brains of the same sex, i.e., the female murine pheromone 2,5-DMPZ did not affect cell proliferation in the SVZ of female mice and the male murine pheromones, the farnesenes, SBT, and DHB, did not affect cell proliferation in the SVZ of male mice. Previous studies have shown that pheromones have suppressive impact on the reproductive system within the same sex, for example, female pheromones suppressed estrus in females (Lee and van der Boot, 1955, 1956; Novotny et al, 1986; Ma et al, 1998) and dominant male odors suppressed sperm activity in subordinate males (Koyama and Kamimura, 1999, 2003). Our findings suggest that, on neurogenesis, pheromones do not have suppressive impact on the same sex.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones

Koyama¹,

Soini²,

Foley³

et al. 2013

Front. Behav. Neurosci.

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Adult neurogenesis in female mice is known to be enhanced by exposure to soiled bedding from males, although the identity of the relevant chemosignals has remained unknown. Here we show that the previously recognized male murine pheromones, the farnesenes and 2-sec-butyl-4,5-dihydrothiazole (SBT), strongly increase cell proliferation in the subventricular zone (SVZ) of adult female mice, but not younger female mice. In addition, we found that a unique female murine pheromone, 2,5-dimethylpyrazine, facilitates similar changes in males. SBT stimulated cell proliferation in the SVZ of only adult females and not in young adult or pre- and post-puberty females. Our study suggests that pheromonal communication between males and females is enhancing reproductive success by controlling the estrous cycle and by promoting cell proliferation in a reciprocal manner.

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Section: Discussionmentioning

confidence: 99%

Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones

Koyama¹,

Soini²,

Foley³

et al. 2013

Front. Behav. Neurosci.

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“…Although it is revealed that the perception of alarm pheromones in male rats, the suppression of sperm motility of subordinates by the dominance pheromone in male mice, and the extension of estrous cycles of female rats by mink odor depend on the VNO (Voznessenskaya et al 1992;Koyama and Kamimura 2003;Kiyokawa et al 2007), direct evidence that mice with VNO ablation are incapable of distinguishing unpleasant odors from pleasant odors is unavailable.…”

Section: Introductionmentioning

confidence: 99%

Vomeronasal organ ablation elicits chemosensory dysfunction and abnormal behavior in mice

Liu

Zhang

et al. 2009

J Ethol

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This study aimed to examine whether the vomeronasal organ (VNO) is a prerequisite in mice to acquire essential information from various social odors and whether long-term VNO dysfunction can elicit behavioral and physiological changes in mice. We used binary choice tests and habituation-dishabituation tests to measure the abilities of male mice to recognize social odors. We found that males with the VNO ablation failed to show olfactory preferences between the odors of mate versus non-mate females, offspring versus non-offspring pups, or oppositesex conspecifics versus predators (cats or rats), but were capable of discriminating between the two treatments in each of the paired odors, suggesting that male mice with VNO ablation might smell out the chemical differences of the two types of odors, but could not extract the biological information contained in the odors. Furthermore, prolonged VNO deficiency resulted in a reduction in crossing behavior in a light/dark box, the frequency of urine marking, and the time spent in the center in an open field. These results indicate that chronic VNO dysfunction led to anxiety-like or submissive behavior. In addition, males with VNO ablation had atrophic adrenal glands and hypertrophic preputial glands, suggesting that VNO dysfunction could damage the physiological conditions to buffer the stress and that pheromone perception deficiency might enhance self-odor production in mice.

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“…Its removal (VNX animals) was performed in different mammal's species. The action of this procedure was studied on detection of predator odor by golden hamsters [21]; perception of alarm pheromone in male rats [22]; lordosis behavior of mice [23]; olfactory sex discrimination or mate recognition in ferrets [24]; sperm motility in male mice [25]; sexual behaviors and intermale aggressive behaviors in prosimian primate [26]; maternal aggression in rats [27]; perception of ephemeral pheromones in mice [28]; reproductive performance and aggression in voles [29]; aggression in female mice [30]; aggression in male mice [31]; lordosis in female hamsters [32]; release of LH in female rats [33]; the role of prolactin in acceleration of puberty in mice [34], and sexual behavior of male hamsters [35].…”

Section: Introductionmentioning

confidence: 99%

Bilateral ablation of the vomeronasal organs produces dramatic changes in the EEG of the main olfactory system during paradoxical sleep

Cervino¹,

Iodice²

2023

World J. Bio. Pharm. Health Sci.

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Background: The vomeronasal organ (VNO) plays an important role in reproductive physiology, behavior, sexual behavior and aggression. Objective: The aim is to report a surprising effect of the removal of the VNO on the cortical electrical activity of the olfactory bulb, piriform lobe and frontal cortex exclusively during paradoxical sleep (PS). Methodology: Seventeen adult armadillos chronically prepared for electrographic recordings were employed. Some animals were subjected to VNO bilateral remove. They were studied during wakefulness and sleep phases. Results: An outstanding phenomenon occurs during PS of armadillos submitted to bilateral ablation of the VNO. There is a dramatic change in the oscillations of the olfactory bulb electrical activity strictly confined to PS. The change consists of the sudden appearance, as soon as PS initiates, of high amplitude gamma oscillations during the whole duration of each PS episode. They disappear as soon as PS comes to an end. The oscillations are also seen in the paleocortex and the frontal neocortex. They disappear after the transverse section of the olfactory peduncles. Conclusions: Our results show the absence of VNO deeply modifies the electrophysiological expression of PS in the olfactory bulb and other extensive brain areas. They are elicited by the centrifugal input to the olfactory bulb. From there they propagate to the piriform and frontal neocortex. These results show a new and subtle role for the organs. Some hypotheses related to the effects of bilateral removal of the VNO are presented.

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Effects of Vomeronasal Organ Removal on the Sperm Motility in Male Mice

Cited by 11 publications

References 13 publications

Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones

Stimulation of cell proliferation in the subventricular zone by synthetic murine pheromones

Vomeronasal organ ablation elicits chemosensory dysfunction and abnormal behavior in mice

Bilateral ablation of the vomeronasal organs produces dramatic changes in the EEG of the main olfactory system during paradoxical sleep

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