Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure

Tsarouhas, Konstantinos; Karatzaferi, Christina; Tsitsimpikou, Christina; Haliassos, Alexander; Kouretas, Demetrios; Pavlidis, Pavlos; Veskoukis, Aristidis S.; Adamopoulos, Stamatis; Kyriakides, Zenon S.; Constantinou, Louis; Koutedakis, Yiannis; Rentoukas, Elias

doi:10.1177/1741826710397099

Cited by 21 publications

(16 citation statements)

References 38 publications

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“…In agreement with the present study, exercise-induced decreases in systemic ADMA concentration have been previously reported in different populations [19,21,[24][25][26][27]. Moderate-intensity, supervised exercise has shown to decrease plasma ADMA concentration in individuals with elevated cardiovascular risk [19], including peripheral arterial disease [26], chronic heart failure [27], obesity [25], and type 1 diabetes [21].…”

Section: Discussionsupporting

confidence: 92%

“…These improvements were accompanied by significant decreases in both systolic and diastolic blood pressure (BP) following twelve weeks of exercise. The exercise-induced reductions in ADMA plasma concentration has been reported elsewhere [19,21,[24][25][26][27], the mechanisms behind this process are not clear. ADMA's cardiovascular effects include vasoconstriction and increased blood pressure [30,31] BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA 1c , glycated hemoglobin; TE, time to exhaustion; VO 2 peak, peak oxygen uptake; HR, heart rate; V E , ventilation; VO 2 T ge , oxygen uptake at gas-exchange threshold; RER, respiratory exchange ratio.…”

Section: Discussionmentioning

confidence: 94%

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Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

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Aims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods:Fourteen women (aged 69 ± 3 yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training.Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation:Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Serre

Simmonds²,

Sabapathy³

et al. 2012

Endocrinol Metabol Syndrome

View full text Add to dashboard Cite

show abstract

“…(Wajchenberg, 2002;Giribela et al, 2011). (Tsarouhas et al, 2011;Turiel et al, 2011;Maeda et al, 2013;Lara et al, 2015) foi realizado com intensidade moderada e três pesquisas realizaram intervenções com esforço intenso (Reid et al, 2010;Thomson et al, 2012;Koichiro tanahash, 2014) e um estudo (Schlager et al, 2011) não relatou a intensidade do exercício.…”

Section: Introductionunclassified

“…Foi possível observar que cinco em estudos (Schlager et al, 2011;Tsarouhas et al, 2011;Turiel et al, 2011;Maeda et al, 2013;Koichiro tanahash, 2014) houve redução dos níveis de AD-MA após a intervenção do exercício aeróbio. Nos estudos que utilizaram o exercício de força ou misto (Reid et al, 2010;Thomson et al, 2012;Lara et al, 2015) não foi observado redução nos níveis plasmáticos de ADMA.…”

Section: Introductionunclassified

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Efeito do exercício físico nos níveis plasmático de Dimetilarginina Assimétrica (ADMA) e suas consequências na disfunção endotelial: uma revisão sistemática

Filho

Aguiar

Sousa

et al. 2017

CM - RS

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Efeito do exercício físico nos níveis plasmático de Dimetilarginina Assimétrica (ADMA) e suas consequências na disfunção endotelial: uma revisão sistemática Effect of physical exercise on plasma levels of asymmetric dimethylarginine (ADMA) and their consequences on endothelial dysfunction: a systematic review associado com exercício físico. Resultados: Os artigos selecionados foram obtidos na íntegra e incluídos na amostra. Cinco tiveram como intervenção exercício aeróbios e dois exercício de força e um que utilizou a metodologia mista tanto o treinamento aeróbio como de força fizeram parte da intervenção. Os níveis plasmáticos de ADMA foram avaliados em todos os estudos. Discursões: Os resultados dessa revisão sistemática indica que indivíduos que praticam exercícios físicos aeróbios regularmente com intensidade moderada parecem ter seus níveis plasmáticos de ADMA reduzidos significativamente. Dessa forma a prática de exercício físico poderia contribuir para uma redução da concentração de ADMA influenciando os níveis de NO e redução da incidência da disfunção endotelial. Conclusão: Foi possível evidenciar que o exercício físico aeróbio pode ter um importante papel na redução dos níveis plasmático de ADMA nos indivíduos submetidos a um programa regular de exercí-cio aeróbio moderada apesar dos mecanismos pelos quais ocorra esta redução não está claro. PALAVRAS-CHAVE:Estresse oxidativo; Oxido nítrico; Doenças cardiovasculares.

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Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis

Pearson

Smart

2017

Heart Fail Rev

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A large body of evidence exists indicating that autonomic imbalance is characteristic of heart failure, with several parameters of autonomic function associated with adverse clinical outcomes. The aim of this systematic review and meta-analysis was to investigate the effects of exercise training on parameters of autonomic function in patients with heart failure and where possible quantify the size of the effect. We conducted database searches (PubMed, EMBASE and Cochrane Trials Register to 31 March 2017) for exercise-based rehabilitation trials in heart failure; using search terms, exercise training, autonomic function, heart rate recovery, heart rate variability and muscle sympathetic nerve activity. Pooled data indicated a statistically significant increase in heart rate recovery at 1 min (HRR) in exercise compared to control groups mean difference 5.90 bpm (95%CI 5.12, 6.69; p < 0.00001). Pooled data also indicated that exercise training improved the short-term heart rate variability (HRV) parameters of root mean square of successive differences between normal heart beats (RMSSD (ms)) [mean difference 10.44 (95%CI 0.60, 20.28, p = 0.04)] and high-frequency normalised units (HF) [mean difference 7.72 (95%CI 3.32, 12.12, p = 0.0006), which are predominantly reflective of parasympathetic activity. Analyses also indicated a statistically significant decrease in muscle sympathetic nerve activity (MSNA) bursts/minute (mean difference - 11.09 (95%CI - 16.18, - 6.00; p < 0.0001) and MSNA bursts/100 heart beats (mean difference - 15.44 (95%CI - 20.95, -9.92; p < 0.00001) in exercise groups compared to controls. With improvements in HRR, HRV and MSNA, exercise training appears to facilitate an improvement in parasympathetic tone and reduction in sympathetic activity.

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Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure

Abstract: A 12-week unsupervised walking programme exhibits a pronounced HRR amelioration, possibly attenuates endothelial damage and induces a concomitant improvement in perceived quality of life in CHF patients.

Cited by 21 publications

References 38 publications

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Rapid Communication – Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetes

Efeito do exercício físico nos níveis plasmático de Dimetilarginina Assimétrica (ADMA) e suas consequências na disfunção endotelial: uma revisão sistemática

Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis

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