Effects of water deprivation on drug pharmacokinetics: Correlation between drug metabolism and hepatic CYP isozymes

Lee, Juhyun; Oh, Jung Mi; Lee, Myung Gull

doi:10.1007/s12272-001-1269-3

Cited by 4 publications

(2 citation statements)

References 108 publications

(213 reference statements)

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“…Further, subjects in the current study were experiencing a clinical episode of diarrhea, whereas previous studies enrolled healthy test subjects for pharmacokinetic analysis [15]. Though based on the initial biochemical analysis none of the animals in the current study were severely dehydrated, moderate levels of dehydration associated with diarrhea may have impaired kidney and liver function, ultimately prolonging systemic meloxicam levels [22]. Furthermore, previous research included calves between 18 and 28 days of age, whereas calves in the current study were less than 2 weeks of age.…”

Section: Discussionmentioning

confidence: 96%

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

Shock¹,

Roche²,

Nagel³

et al. 2020

OJVM

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The non-steroidal anti-inflammatory drug meloxicam is commonly used as adjunct therapy for neonatal calf diarrhea to control pain and inflammation. The objective of this study was to compare the pharmacokinetics of meloxicam in diarrheic pre-ruminant dairy calves dosed either orally or subcutaneously. Twelve pre-ruminant male dairy calves with mild to moderate diarrhea were randomly assigned to receive one of four treatments (three per group): subcutaneous meloxicam (SM, 0.5 mg/kg body weight); an oral bolus meloxicam suspension (OM, 1 mg/kg body weight); an oral meloxicam suspension added to a feeding of oral electrolytes (EM, 1 mg/kg body weight); and an oral meloxicam suspension added to a feeding of milk replacer (MM, 1 mg/kg body weight). The predicted pharmacokinetic parameters for OM, MM, EM, and SM groups were: half-life (56.8 ± 21.7 vs. 136.0 ± 26.6 vs. 85.2 ± 21.7 vs. 36.3 ± 21.7 h), Cmax (4.3 ± 0.4 vs. 3.7 ± 0.4 vs. 3.9 ± 0.4 vs. 2.1 ± 0.4 µg/mL), Tmax (13.3 ± 4.0 vs. 10.7 ± 4.0 vs. 13.3 ± 4.0 vs. 2.7 ± 4.0 h), and AUC 0-∞ (383.4 ± 126.8 vs. 877.8 ± 155.3 vs. 457.1 ± 126.8 vs. 126.4 ± 126.8 h * µg/mL). Oral meloxicam, especially MM, had extended elimination phases relative to SM. All meloxicam therapies provided effective therapeutic levels but all oral therapies (1 mg/kg) provided longer durations of activity than injectable meloxicam (0.5 mg/kg).

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Section: Discussionmentioning

confidence: 96%

The Effect of Delivery Method on the Pharmacokinetic Properties of Meloxicam in Pre-Weaned Dairy Calves with Diarrhea

Shock¹,

Roche²,

Nagel³

et al. 2020

OJVM

View full text Add to dashboard Cite

show abstract

“…6 Moreover, dehydration state also inuences the pharmacokinetics of therapeutic agents. 3,7 In the other hand, abstaining from water might also have benecial effects on body, for example, water deprivation stimulated the release of endogenous vasopressin which can be used for the treatment of acute variceal bleeding. 8 To survive the water deprivation, living organisms may regulate their molecular expression or concentration to response or adapt to the adverse environment.…”

Section: Introductionmentioning

confidence: 99%