Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells

Antiapoptotic effects of dietary antioxidants towards N‐nitrosopiperidine and N‐nitrosodibutylamine‐induced apoptosis in HL‐60 and HepG2 cells

“…Thus, we suggest that low concentrations of DADS could exert an opposite effect in HL-60 cells, decreasing caspase-3 activation and PARP cleavage. In HepG2 cells, De Martino et al (2006) reported that 50 μM DADS did not activate the apoptotic process, confirming the hypothesis that HepG2 cells are more resistant that HL-60 cells towards the pro-apoptotic effect induced by DADS. For that reason, we suspect that the induction of apoptosis may depend on the toxicity of these compounds tested at high doses.…”

The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis

“…Apoptosis and its associated cellular events have been targeted for the cancer therapies of various malignant cancers, including melanoma (Thompson, 1995;Lowe and Lin, 2000). p53 is responsible for inducing apoptosis as well as increasing melanogenesis in melanoma (el-Deiry et al, 1992(el-Deiry et al, , 1993Vousden, 2000;De Martino et al, 2006). PGP EtOAc extracts induced p53 in B16F10 cells.…”

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

“…This is due, in part, to its ability to induce apoptosis in vitro (4) and to inhibit the formation and growth of tumors in vivo (5,6). DADS has been shown to inhibit the in vitro and in vivo growth of breast, liver, lung, gastric, colon, and prostate cancers, as well as neuroblastoma and leukemia cell lines (5,(7)(8)(9)(10)(11)(12)(13)(14). Therefore, DADS may be a useful therapeutic tool for the prevention of environmentally induced cancers.…”