Effects of Welsh onion on oxidation of low-density lipoprotein and nitric oxide production in macrophage cell line RAW 264.7

Wang, Bor Sen; Chen, Jia Huey; Liang, Yu Chih; Duh, Pin Der

doi:10.1016/j.foodchem.2004.06.009

Cited by 38 publications

(23 citation statements)

References 54 publications

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“…Rice-Evans et al (1995) noted that polyphenolic compounds were active mainly due to their redox properties, which allowed them to act as reducing agents, hydrogen donators, and reactive oxygen quenchers. Wang et al (2005) reported that the polyphenol compounds in A. fistulosum were the main active compounds contributing to antioxidant activity. Further biochemical analyses and examinations of the chromosomal assignment of genes associated with polyphenol production are necessary to reveal the polyphenol production related to antioxidant activity in A. fistulosum and shallot.…”

Section: Discussionmentioning

confidence: 99%

Single Alien Chromosome Additions from Shallot (Allium cepa L. Aggregatum group) Increase Endogenous Polyphenol Contents in Japanese Bunching Onion

Yaguchi

Yamauchi

Shigyo

2009

J. Japan. Soc. Hort. Sci.

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Eight members of the Allium fistulosum L. -shallot (Allium cepa L. Aggregatum group) monosomic addition line (2n = 17, FF + 1A-FF + 8A) proved to be very effective in revealing the effects of single alien chromosomes from A. cepa on the production of polyphenol in the green leaf tissues of A. fistulosum. The determination of polyphenol content in the green leaf tissue of these monosomic additions was carried out monthly from January 2002 to December 2003. Throughout the 2-year period, every monosomic addition accumulated polyphenols in green leaf tissues. Two-way ANOVA revealed significant differences, at the 1% level, in the polyphenol contents of the various monosomic addition types as well as in various months. Dunnett's test showed that four monosomic additions (FF + 2A, FF + 5A, FF + 6A, and FF + 8A) caused a greater increase in the amount of polyphenol content than did A. fistulosum. The levels of polyphenol accumulation in the remaining four monosomic additions and A. fistulosum were almost the same. A phenylalanine ammonialyase gene of shallot was allocated to chromosome 2A using two sets of the monosomic additions. These results indicate that the genes related to polyphenol production may be located on the 2A, 5A, 6A, and 8A chromosomes of shallot.

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Section: Discussionmentioning

confidence: 99%

Single Alien Chromosome Additions from Shallot (Allium cepa L. Aggregatum group) Increase Endogenous Polyphenol Contents in Japanese Bunching Onion

Yaguchi

Yamauchi

Shigyo

2009

J. Japan. Soc. Hort. Sci.

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“…It can slowly oxidize a number of compounds by crossing the membrane. Hydrogen peroxide is rapidly composed into oxygen and water which results in the production of (-OH) that initiate lipid per-oxidation which leads to DNA damage [33]. Aqueous extract of mushroom's mycelial cultures effectively scavenged hydrogen peroxide and may attribute to the presence of phenolic groups that can donate electrons to hydrogen peroxide, thereby neutralizing it into water.…”

Section: Bains and Tripathimentioning

confidence: 99%

Evaluation of Antioxidant and Anti-Inflammatory Properties of Aqueous Extract of Wild Mushrooms Collected From Himachal Pradesh

Bains¹,

Tripathi²

2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to elucidate phytochemical contents, antioxidant, and anti-inflammatory activity of wild mushrooms collected from Himachal Pradesh.Methods: Quantitative analysis of phytochemical constituents was carried out using standard methods while 1,1 diphenylpicrylhydrazyl nitric oxide, hydrogen peroxide-free radical scavenging assay were used to evaluate the antioxidant properties of selected wild mushrooms. Anti-inflammatory capacity of samples was evaluated by human red blood cell membrane stabilization and albumin denaturation inhibition method. Results:The results obtained revealed that Pleurotus floridanus showed higher total phenol, flavonoid carotenoid, and ascorbic acid contents of 61.13±2.3 mg/g, 15.2±1.13 mg/g, 12.42±0.42 µg/g, 17.36±0.40 µg/g, and 14.55±0.58 mg/g. All the species showed antioxidant potential, but P. floridanus proved to be more active while Macrocybe sp. proved to be least one. Conclusion:The mushroom species analyzed have been showed to be good source of phytoconstituents, antioxidants, and also possess antiinflammatory properties, thus can be used in the management of oxidative stress-induced disease.

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“…24 The main goal of the present study is to evaluate the beneficial effect of EECC and AECC on antioxidant status in STZ-induced diabetic rats. The exaggerated free radical production through STZ-mediated experimental diabetes resulted in the raised levels of lipid peroxides and hydro peroxides by oxidative degradation of polyunsaturated fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Anti-Oxidant Study of Citrullus Colocynthis Roots in Streptozotocin Induced Diabetic Rats

Kalva¹,

Nerella²

2018

Int. Res. J. Pharm.

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Objective: The main objective is to investigate anti-oxidant activity of ethanoic and aqueous extract of Citrullus colocynthis (EECC &AECC) in streptozotocin -induced diabetic rats. Methods: Acute toxicity study of EECC and AECC was carried out in rats to determine its dose for further study. Oral glucose tolerance test was performed to evaluate EECC and AECC on elevated blood glucose levels. Diabetes was induced in rats by administration of streptozotocin (STZ) (45mg/kg) and it was confirmed after 48hrs after induction. Both the extracts of Citrullus colocynthis was given intraperitoneally to the diabetic rats up to 15 days and blood glucose levels were estimated after 10 days. On the 15 th day of the experiment, rats were sacrificed for the anti-oxidant estimation in liver homogenate. Results: Acute toxicity of EECC and AECC did not show toxicity and death up to dose of 2000mg/kg. Both the extracts at 200 and 300mg/kg doses significantly (p<0.001) reduced blood glucose levels in OGTT. Both the doses of EECC and AECC treatment significantly (p<0.001 & p<0.001) showed free radical scavenging action with DPPH, NO and Reducing power assay in-vitro and in-vivo when compared with STZ treated rats were found to be very close to the standard Ascorbic acid. Conclusion: From the above results it was concluded that the plant extract is having the ability of managing hyperglycemia and complications of diabetes in STZ induced diabetic rats. Hence the plant may be considered as one of the source for the isolation of new oral anti-hypoglycemic agent.

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Effects of Welsh onion on oxidation of low-density lipoprotein and nitric oxide production in macrophage cell line RAW 264.7

Cited by 38 publications

References 54 publications

Single Alien Chromosome Additions from Shallot (Allium cepa L. Aggregatum group) Increase Endogenous Polyphenol Contents in Japanese Bunching Onion

Single Alien Chromosome Additions from Shallot (Allium cepa L. Aggregatum group) Increase Endogenous Polyphenol Contents in Japanese Bunching Onion

Evaluation of Antioxidant and Anti-Inflammatory Properties of Aqueous Extract of Wild Mushrooms Collected From Himachal Pradesh

Anti-Oxidant Study of Citrullus Colocynthis Roots in Streptozotocin Induced Diabetic Rats

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