Anti-Oxidant Study of Citrullus Colocynthis Roots in Streptozotocin Induced Diabetic Rats

Kalva, Sireesha; Nerella, Raghunandan

doi:10.7897/2230-8407.09343

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The therapy was begun on the 10th day after the induction of alloxan monohydrate. A dose of 150 and 300 mg/kg of the methanolic extract of E. prostrata was administered orally to groups III and IV, respectively, with slight modi cations [20]. The Glibenclamide (10 mg/kg/day) was given orally to group V as a standard drug.…”

Section: Drug Administrationmentioning

confidence: 99%

Investigating the anti-diabetic, anti-depressant and anti-anxiety effect of euphorbia prostrata in alloxan monohydrate induced mice

Rizwan,

Rafiq,

Waqas

et al. 2024

Preprint

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The present study aims to scientifically validate certain pharmacological activities of Euphorbia prostrata (E. prostrata) plant extracts and investigate their anti-diabetic, anti-depressant, and anti-anxiety effects. The extraction process employed the Soxhlet apparatus method, using methanol as the solvent. Thirty albino mice were purchased from the local market and divided into five groups, each comprising six mice. Group I served as the negative control, while Group II acted as the positive control. Groups III and IV received two different concentrations (150 and 300 mg/kg) of methanolic plant extract, and Group V was treated with the standard drug Glibenclamide at 10 mg/kg. Blood glucose levels were measured using a glucometer. In diabetic control mice treated with high doses of the plant extract, the blood glucose-lowering impact was more pronounced during this period. Glibenclamide also reduced glucose concentrations comparably to the high dose of plant extract. The anti-diabetic effect of mice administered 300 mg/kg methanol extract paralleled that of mice receiving 10 mg/kg Glibenclamide on the 31st day. To evaluate the anti-depressant activity of E. prostrata, the forced swim test, tail suspension test, and sucrose preference test were conducted. Similarly, the anti-anxiety activity was assessed through the open field test, novel object recognition test, and elevated plus maze test. These tests were carried out on days 1st, 15th, and 30th, and on days 2nd, 16th, and 31st during treatment, respectively, except for the novel object recognition test, which was performed on the last two days of treatment. Results from the behavioural tests indicated that E. prostrata exhibited a potent effect against depressive and anxiolytic behaviour. Statistical analysis using one-way ANOVA presented all results as mean ± SD, with significance considered at P < 0.05.

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Section: Drug Administrationmentioning

confidence: 99%

Investigating the anti-diabetic, anti-depressant and anti-anxiety effect of euphorbia prostrata in alloxan monohydrate induced mice

Rizwan,

Rafiq,

Waqas

et al. 2024

Preprint

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“…15 days after the injection of STZ, the remediation began with CC. Tus, the aqueous extract of CC (200 mg/kg) was administered orally every day for 40 consecutive days [27]. A dose response study was conducted to reaching the dose with maximum efectiveness.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

“…Consequently, the diabetic rats in all the treated groups received CCAE (200 mg/kg) as the daily oral treatment [23]. Also, other authors such as Kalva et al used a dose of 200 mg/kg [27].…”

Section: Induction Of Diabetesmentioning

confidence: 99%

The Diabetic Lung Can Be Ameliorated by Citrullus colocynthis by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes

Bejeshk

Bagheri

Salimi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes impacts various organs in the body and some reports showed that the lung is also affected by diabetes, and an imbalance of inflammation and oxidative stress may participate to diabetic lung impairments. The present study is conducted to assess the impacts of Citrullus colocynthis (CC) on some aspects of these impairments. Methods. Frothy two male Wistar rats (3-4 months old and weighing 200–250 g) were used in the present research. Animals were divided into 3 groups of control, Diabetes, and Diabetes + Drug. CC was administered to diabetic rats orally. The lung tissue and BALF oxidative stress and inflammatory indices including the MDA, TAC, SOD, Gpx, TNFα, IL-6, IL-17, and IL-10 were evaluated by the ELISA method. Results. Our observations disclosed the ameliorative impacts of CC administration against oxidative stress and inflammation imbalance. Also, it was found that CC improved body weight and fasting blood sugar in rats with diabetes. Conclusion. We can conclude that the administration of CC can be effective in improving diabetic lungs in rats.

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Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

Salehi

Quispe

Sharifi‐Rad

et al. 2021

Phytotherapy Research

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Oxidative stress is the imbalance between reactive oxygen species (ROS) production, and accumulation and the ability of a biological system to clear these reactive products. This imbalance leads to cell and tissue damage causing several disorders in human body, such as neurodegeneration, metabolic problems, cardiovascular diseases, and cancer. Cucurbitaceae family consists of about 100 genera and 1,000 species of plants including mostly tropical, annual or perennial, monoecious, and dioecious herbs. The plants from Cucurbita species are rich sources of phytochemicals and act as a rich source of antioxidants. The most important phytochemicals present in the cucurbits are cucurbitacins, saponins, carotenoids, phytosterols, and

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Anti-Oxidant Study of Citrullus Colocynthis Roots in Streptozotocin Induced Diabetic Rats

Cited by 4 publications

References 15 publications

Investigating the anti-diabetic, anti-depressant and anti-anxiety effect of euphorbia prostrata in alloxan monohydrate induced mice

Investigating the anti-diabetic, anti-depressant and anti-anxiety effect of euphorbia prostrata in alloxan monohydrate induced mice

The Diabetic Lung Can Be Ameliorated by Citrullus colocynthis by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes

Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders

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