Effects of wheat peptide supplementation on anti-fatigue and immunoregulation during incremental swimming exercise in rats

Zheng, Zhiqiang; Yang, Xiaoxue; Jin, Lan; Qian, Ping; Hao, Limin; Wang, Zhenyu; Guo, Shuntang

doi:10.1039/c7ra07860a

Cited by 14 publications

(8 citation statements)

References 57 publications

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“…Zheng et al [116] gave rats low (20 mg/kg/d) and high (100 mg/kg/d) dose wheat peptide antioxidant supplement together with incremental swimming exercise for 4 weeks. The researchers eventually concluded that taking both doses of the supplement could boost GPX antioxidant levels.…”

Section: The Effect Of Different Doses Of Antioxidant Supplements On Osmentioning

confidence: 99%

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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Excessive release of inflammatory cytokines and oxidative stress (OS) are triggering factors in the onset of chronic diseases. One of the factors that can ensure health in humans is regular physical activity. This type of activity can enhance immune function and dramatically prevent the spread of the cytokine response and OS. However, if physical activity is done intensely at irregular intervals, it is not only unhealthy but can also lead to muscle damage, OS, and inflammation. In this review, the response of cytokines and OS to exercise is described. In addition, it is focused predominantly on the role of reactive oxygen and nitrogen species (RONS) generated from muscle metabolism and damage during exercise and on the modulatory effects of antioxidant supplements. Furthermore, the influence of factors such as age, sex, and type of exercise protocol (volume, duration, and intensity of training) is analyzed. The effect of antioxidant supplements on improving OS and inflammatory cytokines is somewhat ambiguous. More research is needed to understand this issue, considering in greater detail factors such as level of training, health status, age, sex, disease, and type of exercise protocol.

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Section: The Effect Of Different Doses Of Antioxidant Supplements On Osmentioning

confidence: 99%

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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“…Caspase-3 is the main terminal shear enzyme in apoptosis and plays an irreplaceable role in apoptosis (Zheng et al, 2017) . sIgA, as the main antibody in mucosal immunity, is responsible for an important immune function (Feng et al, 2021) .…”

Section: Effect Of Smot On Immune Functionmentioning

confidence: 99%

Anti-fatigue effect of small molecule oligopeptides from tilapia (Oreochromis Mossambicus) in mice

Peng

Song

et al. 2022

Food Sci. Technol

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In order to promote the development and application of small molecule oligopeptides from tilapia (SMOT), its anti-fatigue effect was evaluated by using exhaustive swimming in mice. The results showed that compared with the negative control group, SMOT could significantly prolong the exhausted swimming time of mice, reduce blood lactic acid, blood urea nitrogen and malondialdehyde content, and could significantly improve liver glycogen storage status. Meanwhile, the activities of superoxide dismutase and glutathione peroxidase of the mice gavaged with SMOT were significantly higher than those in the negative control group. In addition, SMOT could increase the activity of immune factor IL-2, stimulate the secretion of sIgA and regulate the level of inflammatory factors. So SMOT had significant anti-fatigue effect. Its anti-fatigue effect was exerted by increasing energy reserves, eliminating the accumulation of metabolites, reducing oxidative stress, and improving the body's immune function.

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“…Wheat peptides (WP) are a type of polypeptide derived from wheat gluten hydrolysate with different nutritional, functional, or biological properties than wheat protein, which exhibits antifatigue, [10] antioxidant, [11] and antihypertensive activities, [12] and preventing gastric mucosal damage. [13] It can regulate intestinal physical (intestinal epithelial layer, e.g., zonula occludens-1 and claudin), [14] chemical (mucus layer substances, e.g., mucin-2, secretory immunoglobulin A), [15] and biological barrier functions (microbiome layer adhere to the intestine), [16] which are essential for gut homeostasis and the pathophysiology of intestine-related disorders.…”

Section: Introductionmentioning

confidence: 99%

“…[17] In terms of amino acid composition, glutamic acid (Glu) and glutamine (Gln) were the most abundant amino acids in WP. [10] As a functional amino acid, Glu was considered an essential amino acid for maintaining intestinal health and systemic homeostasis of human newborns. [18] During normal and pathologic settings, Gln may enhance enterocyte proliferation, modulate the expression of tight junction proteins, reduce pro-inflammation, and protect cells from apoptosis and cellular stress.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice

Wang

Shen

Zhang

et al. 2022

Molecular Nutrition Food Res

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Scope: Wheat peptides (WP) are rich in glutamic acid, glutamine, and other bioactive compounds that may benefit gut function and health. This study aims to evaluate the effects of regular consumption of WP on constipation-induced complications and gut microbiota in humans and mice. Methods and results: A randomized trial of 49 functional constipation participants is conducted. The weekly amount of spontaneous bowel movements (SBM) increases by 2.09 per week after WP treatment, and by 0.40 per week among the placebo group (PL). Concomitantly, the secondary outcomes show significant improvements in the quality of life-related to constipation (PAC-QOL), constipation severity, and satisfaction with the intervention. In the animal study, WP effectively alleviates constipation symptoms and affects the secretion of intestinal mobility-related neurotransmitters and gastrointestinal hormones in loperamide-induced constipation mice. Additionally, WP regulates the gene and protein expression levels of water-electrolyte metabolism and intestinal mobility. Furthermore, WP treatment decreases the abundance of several gut microbiota positively correlated to constipation (Turicibacter, Bacteroides_f_Bacteroidaceae, and Streptococcus) in mice. Conclusion: WP ameliorates constipation in humans and mice, which could be partly explained by improving water-electrolyte metabolism, boosting intestinal motility, and reshaping gut microbiota.

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Effects of wheat peptide supplementation on anti-fatigue and immunoregulation during incremental swimming exercise in rats

Abstract: This study elucidated the effects of wheat peptide administration on anti-fatigue and immunoregulation functions in rats.

Cited by 14 publications

References 57 publications

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Anti-fatigue effect of small molecule oligopeptides from tilapia (Oreochromis Mossambicus) in mice

Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice

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