Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model

Zhang, Caiqing; Li, Feng; Li, Ming; Dong, Chongjuan; Zhang, Wei

doi:10.5582/bst.2012.v6.5.262

Cited by 19 publications

(13 citation statements)

References 19 publications

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“…Wistar rats (280 ± 40 g) were purchased from Experimental Animal Center of West China College of Pharmacy, Sichuan University (Certificate number SCXK (Chuan) 2014-11, Chengdu, China). The rats were housed in laboratory at room temperature (22–24°C) and constant humidity (40–70%) with a 12 h light-dark cycle and provided food and water ad libitum [ 31 , 32 ]. All procedures were in strict accordance with the Chinese legislation on the use and care of laboratory animals and the guidelines established by Institute for Experimental Animals of Sichuan University and were approved by the Sichuan University Committee on Animal Care and Use.…”

Section: Methodsmentioning

confidence: 99%

“…All procedures were in strict accordance with the Chinese legislation on the use and care of laboratory animals and the guidelines established by Institute for Experimental Animals of Sichuan University and were approved by the Sichuan University Committee on Animal Care and Use. After one week of adaptation, eligible animals were randomly assigned into six groups (8 rats in each group) [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

“…The COPD-like rat model was established by combination of exposure of CS and intratracheal instillation of LPS described as previous studies [ 25 , 31 , 32 , 42 ]. A commercially available filter cigarette (Tianxiaxiu brand cigarette, Tobacco Chuanyu Industrial Co. Ltd., China) contains 0.8 mg of nicotine and 10 mg of tar.…”

Section: Methodsmentioning

confidence: 99%

“…One study showed that baicalin, which is an extract from roots of the plant Scutellaria baicalensis , inhibits inflammation and NF- κ B activation in cigarette smoke induced inflammatory models [ 31 ]. Another research reported that Xiaoqinglong decoction could significantly mitigate pulmonary functional and structural impairment in a COPD-like rat model [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Isosteroid Alkaloid Imperialine from Bulbs ofFritillaria cirrhosaMitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model

Wang

et al. 2016

Mediators of Inflammation

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Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. Present therapies for COPD have limited effect on reducing the progression of COPD and suppressing the inflammatory response in the lung. Bulbs of Fritillaria cirrhosa D. Don (BFC) have been used in many Asian countries for a long time to treat pulmonary diseases, such as cough, expectoration, and asthma. Steroidal alkaloids are the major biological active constituents in BFC, whereby imperialine is one of the important steroidal alkaloids. So far, there are no studies reporting the effect of imperialine on COPD. In this study, we investigated the effect of imperialine on pulmonary function and structure and inflammation in a COPD-like rat model which was induced by the combination of exposure to CS and intratracheal administration of LPS. Our data show that imperialine mitigates pulmonary functional and structural impairment and suppressed inflammatory response in a COPD-like rat model by mediating expression of related cytokines in lung tissues of the COPD-like rats, such as IL-1β, IL-6, IL-8, TNF-α, NF-κB, TGF-β1, MMP-9, and TIMP-1.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Isosteroid Alkaloid Imperialine from Bulbs ofFritillaria cirrhosaMitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model

Wang

et al. 2016

Mediators of Inflammation

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“…The traditional Oriental medicine, So-Cheong-Ryong-Tang (CY), which is also known as Xiao-Qing-Long Tang in China and Sho-Seiryu-To in Japan, is an herbal mixture that has for hundreds of years been used to treat diseases such as allergic rhinitis and asthma in Asian countries [ 5 , 6 ]. Recent evidence indicates that the specific bioactivities of CY include the modulation of gastrointestinal motility [ 7 ], the influencing of gene expression in a rodent model of chronic obstructive pulmonary disease [ 8 ], the regulation cytokines and chemokines on allergic airway inflammation [ 5 ], and the induction of apoptosis in human lung cancer cells [ 9 ]. Additionally, previous studies from our laboratory have suggested that CY has protective effects against hydrogen peroxide-induced hepatotoxicity [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells

Yim

Kim

Jung

et al. 2015

BMC Complement Altern Med

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BackgroundSo-Cheong-Ryong-Tang (CY), a traditional herbal formula, mainly has been shown to possess allergic rhinitis and asthma for hundreds of years in Asian countries. Although this medicine has been attracted Asian scientists with investigating mechanisms of action against inflammatory-related diseases, there is a little available information on the anti-cancer effect of CY, especially on the fermented form (FCY). In this study, we explored the chemopreventive/chemotherapeutic efficacy of FCY against cancer cells and proved the efficacy of FCY through performing in vivo xenograft assay.MethodsCY was fermented with bacteria and lyophilized. For analysis of the constituents of CY and FCY, high performance liquid chromatography (HPLC)-DAD system was performed. To detect the anti-cancer effect of FCY, cell viability assay, caspase activity assay, cell cycle analysis, and Western blot analysis were performed in AGS human gastric cancer cells. The inhibitory effects of tumor growth by CY and FCY were evaluated in athymic nude mice inoculated with HCT116 human colon cancer cells.ResultsAs a result of analyzing the 11components present in CY and FCY, the contents of ephedrine HCl, glycyrrhizin, gingerol, schisandrin, and gomisin A were respectively increased by fermentation in FCY. The treatment of CY or FCY inhibited the viability of AGS cells, interestingly, the inhibition of cancer cell growth was enhanced by fermentation of CY. FCY induced the apoptosis through activating the caspase-3, −8, and −9. Additionally, FCY regulated the activation of mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK). In vivo xenografts, administration of FCY significantly inhibited the tumor formation, and improved the anti-tumor effect compared to that of CY in athymic nude mice.ConclusionsFCY indicated significant anti-cancer effects, and its efficacy against tumor formation was improved than that of CY, therefore, FCY might be used for applications of traditional medicine against cancer in modern complementary and alternative therapeutics.Graphical Abstractᅟ

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Pretreatment with mechano-growth factor E peptide protects bone marrow mesenchymal cells against damage by fluid shear stress

Hao

Sha

et al. 2014

Biotechnol Lett

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Improper fluid shear stress (FSS) can cause serious damages to bone marrow mesenchymal stem cells (MSCs). Mechano-growth factor (MGF) E peptide pretreatment was proposed to protect MSCs against FSS damage in this study. MSCs were exposed to FSS for 30 min after they were pretreated with MGF E peptide for 24 h. Then, the effects of MGF E peptide on the viability, proliferation and cell apoptosis of MSCs were investigated. MGF E peptide pretreatment could recover the cellular metabolic activity of MSCs reduced by 72 dyne cm(-2) FSS and had a synergistic effect with FSS on the cellular metabolic viability of MSCs under 24 and 72 dyne cm(-2) FSS. These results suggested that MGF E peptide pretreatment could be an effective method for the protection of FSS damage in bone tissue engineering.

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Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model

Cited by 19 publications

References 19 publications

The Isosteroid Alkaloid Imperialine from Bulbs ofFritillaria cirrhosaMitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model

The Isosteroid Alkaloid Imperialine from Bulbs ofFritillaria cirrhosaMitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model

Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells

Pretreatment with mechano-growth factor E peptide protects bone marrow mesenchymal cells against damage by fluid shear stress

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