Effects of zinc acexamate on gastric mucosal resistance factors

Bulbena, O.; Escolar, Ginés; Martí-Bonmatí, E.; Esplugues, Juan V.

doi:10.1016/0014-2999(85)90415-7

Cited by 36 publications

(12 citation statements)

References 18 publications

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“…However, further studies will be necessary to explain the differences between the various calcium blockers, to characterize their effects completely, and to know to what extent they are responsible for the antiulcerogenic activity described for verapamil (Ogle et al, 1985) and other substances characterized as calcium antagonists Esplugues et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo

Cortijo

Esplugues

et al. 1986

British J Pharmacology

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1Experiments were designed to evaluate the effects of three calcium channel blockers (verapamil, diltiazem and cinnarizine) on gastric emptying and secretion in the rat 2 Pretreatment with the calcium blockers delayed gastric emptying of phenol red in a dose-dependent manner. Verapamil was the most effective of the agents tested. 3 Verapamil and diltiazem inhibited gastric acid secretion in the pylorus-ligated rat without affecting pepsin output. Cinnarizine was ineffective in this model. 4 When the perfused lumen of the anaesthetized rat was used, verapamil was found to inhibit responses to carbachol or histamine more than those to pentagastrin. Further, we found a greater sensitivity to verapamil for basal compared with vagal-stimulated (2-deoxy-D-glucose) acid secretion. Neither diltiazem nor cinnarizine modified gastric acid secretion in this experimental model. 5 These findings are discussed in relation to the role of extracellular calcium in gastric motility and secretion, and the existence of a regional and functional selectivity for calcium blockers is proposed.

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Section: Discussionmentioning

confidence: 99%

Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo

Cortijo

Esplugues

et al. 1986

British J Pharmacology

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“…Although eicosanoids, mainly prostaglandins, are clearly involved in the mechanisms that protect the gastric mucosa against an acidic environment, the mucosal protection conferred by zinc compounds does not seem to be exclusively related to these autacoids, but also to the enhancement of mucus secretion [12,22], changes of the mucus composition [12], maintenance of gastric barrier integrity [10], stabilization of lysosomal membranes, and inhibition of mast cell degranulation [23,24]. If the protection conferred by zinc when it is complexed with tenoxicam also involves similar mechanisms is not clear.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity and Gastric Lesions Induced by Zinc-Tenoxicam

et al. 2003

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Oral administration of tenoxicam or zinc-tenoxicam complex inhibited to a similar extent carrageenin-induced paw oedema and granulomatous tissue formation in rats as well as the acetic acid induced writhing response in mice. Gastric lesions induced by oral administration of zinc-tenoxicam were reduced in number and severity when compared with those induced by tenoxicam or the co-administration of tenoxicam and zinc acetate. However, after intraperitoneal administration, both zinc-tenoxicam and tenoxicam plus zinc acetate induced a reduced number of gastric lesions as compared with tenoxicam.

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“…Since 1+ lesions induce the least discomfort, the use of the complex would not be justified in case of parenteral administration. However, considering oral administration, the presence of zinc, complexed or in combination, is important because it reduces the severity of gastric lesions as a result of both local (13) and systemic (29) effects. Different models have been used to evaluate the effect of potential antiulcer drugs, raising the question of what model has a greater predictive value.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats

Santos

Feres

Melo

et al. 2004

Braz J Med Biol Res

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We investigated the anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex (5.5 or 11 mg/kg) in male Wistar rats (180-300 g, N = 6) and compared it to free diclofenac (5 or 10 mg/ kg) and to the combination of diclofenac (5 or 10 mg/kg) and zinc acetate (1.68 or 3.5 mg/kg). The carrageenin-induced paw edema and the cotton pellet-induced granulomatous tissue formation models were used to assess the anti-inflammatory activity, and the Hargreaves model of thermal hyperalgesia was used to assess the antinociceptive activity. To investigate the effect of orally or intraperitoneally (ip) administered drugs on cold-induced gastric lesions, single doses were administered before exposing the animals to a freezer (-18ºC) for 45 min in individual cages. We also evaluated the gastric lesions induced by multiple doses of the drugs. Diclofenac plus zinc complex had the same anti-inflammatory and antinociceptive effects as diclofenac alone. Gastric lesions induced by a single dose administered per os and ip were reduced in the group treated with zinc-diclofenac when compared to the groups treated with free diclofenac or diclofenac plus zinc acetate. In the multiple dose treatment, the complex induced a lower number of the most severe lesions when compared to free diclofenac and diclofenac plus zinc acetate. In conclusion, the present study demonstrates that the zincdiclofenac complex may represent an important therapeutic alternative for the treatment of rheumatic and inflammatory conditions, as its use may be associated with a reduced incidence of gastric lesions. Correspondence

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Effects of zinc acexamate on gastric mucosal resistance factors

Cited by 36 publications

References 18 publications

Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo

Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo

Anti-Inflammatory Activity and Gastric Lesions Induced by Zinc-Tenoxicam

Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats

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