Effects of Zinc Supplementation on Markers of Insulin Resistance and
                    Lipid Profiles in Women with Polycystic Ovary Syndrome: a Randomized,
                    Double-blind, Placebo-controlled Trial

Foroozanfard, Fatemeh; Jamilian, Mehri; Jafari, Zahra; Khassaf, A.; Hosseini, Agha Fatemeh; Khorammian, H.; Asemi, Zatollah

doi:10.1055/s-0035-1548790

Cited by 34 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced levels of circulating zinc are common in obesity ( 8 , 9 ) whereas recent studies report conflicting results with regard to the levels of circulating zinc in the blood of PCOS women ( 3 – 5 ). However, zinc supplementation has several beneficial effects on the metabolic status in PCOS women ( 6 , 48 ). So far, limited attempts have been made to understand the underlying molecular events of the zinc disturbances in PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…Altered serum-zinc levels are found in women with PCOS compared to body weight-matched, healthy controls, and both increased and decreased zinc levels have been reported ( 3 – 5 ). Interestingly, 8 weeks of zinc supplementation has beneficial effects on fasting plasma glucose, insulin resistance as measured by homeostatic model assessment (HOMA index), and the lipid profile in PCOS women ( 6 ). Similar to PCOS, a disturbed zinc homeostasis is also common in type 2 diabetic and obese individuals, which is evident by the presence of hypozincemia ( 7 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome

et al. 2017

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels, and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS; and zinc supplementation can ameliorate metabolic disturbances in PCOS. In adipose tissue, expression of zinc influx transporter ZIP14 varies with body mass index (BMI), clinical markers of metabolic syndrome, and peroxisome proliferator-activated receptor gamma (PPARG). In this study, we investigated expression levels of ZIP14 and PPARG in subcutaneous adipose tissue of 36 PCOS women (17 lean and 19 obese women) compared with 23 healthy controls (7 lean and 16 obese women). Further, expression levels of zinc transporter ZIP9, a recently identified androgen receptor, and zinc efflux transporter ZNT1 were investigated, alongside lipid profile and markers of glucose metabolism [insulin degrading enzyme, retinol-binding protein 4 (RBP4), and glucose transporter 4 (GLUT4)]. We find that ZIP14 expression is reduced in obesity and positively correlates with PPARG expression, which is downregulated with increasing BMI. ZNT1 is upregulated in obesity, and both ZIP14 and ZNT1 expression significantly correlates with clinical markers of altered glucose metabolism. In addition, RBP4 and GLUT4 associate with obesity, but an association with PCOS as such was present only for PPARG and RBP4. ZIP14 and ZNT1 does not relate to clinical androgen status and ZIP9 is unaffected by all parameters investigated. In conclusion, our findings support the existence of a zinc dyshomeostasis in adipose tissue in metabolic disturbances including PCOS-related obesity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Studies documented increases in HOMA-IR, HOMA2-IR (homeostasis model assessment-insulin resistance index), and also in concentration of insulin, fasting insulin, glucose and fasting glucose [18,27,46,48,49], but decreases in GIR (glucose/insulin ratio) and QUICKI (quantitative insulin sensitivity check index) [18,27]. It was noted that zinc supplementation (Table 3) seems to be beneficial for patients with PCOS, because it was observed to significantly decrease both insulin concentration and HOMA-IR index [52,53]. Hyperinsulinemia and insulin resistance have been linked in the pathogenesis of PCOS and also may contribute to type 2 diabetes mellitus and micro-and macrovascular complications as long-term risks [63][64][65].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

View full text Add to dashboard Cite

Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

show abstract

“…A dose of 1,200 mg/d omega-3 long-chain polyunsaturated fatty acids reduced fasting glucose and insulin but not weight (58). Other small trials demonstrate potential benefits of selenium supplements of 200 mg/d in decreasing serum insulin and triglycerides (59), and of 220 mg/d zinc sulfate in reducing fasting glucose and insulin levels (60).…”

Section: Dietary Supplements Potentially Beneficial For Pcosmentioning

confidence: 99%

Environmental determinants of polycystic ovary syndrome

Merkin

Phy

Sites

et al. 2016

Fertility and Sterility

114

View full text Add to dashboard Cite

In this review, we summarize existing research on a variety of environmental factors potentially involved in the etiology, prevalence, and modulation of polycystic ovary syndrome (PCOS), and we suggest avenues for future research. The main environmental factors we consider include environmental toxins, diet and nutrition, socioeconomic status, and geography. There is some evidence that environmental toxins play a role in disrupting reproductive health, but there is limited research as to how these toxins may affect the development of PCOS. Although research has also shown that PCOS symptoms are reduced with certain dietary supplements and with weight loss among obese women, additional research is needed to compare various approaches to weight loss, as well as nutritional factors that may play a role in preventing or mitigating the development of PCOS. Limited studies indicate some association of low socioeconomic status with certain PCOS phenotypes, and future research should consider socioeconomic conditions during childhood or adolescence that may be more relevant to the developmental onset of PCOS. Finally, the limited scope of comparable international studies on PCOS needs to be addressed, because global patterns of PCOS are potentially valuable indicators of cultural, environmental, and genetic factors that may contribute to excess risk in certain regions of the world.

show abstract

Effects of Zinc Supplementation on Markers of Insulin Resistance and Lipid Profiles in Women with Polycystic Ovary Syndrome: a Randomized, Double-blind, Placebo-controlled Trial

Abstract: Taken together, 220 mg zinc sulfate supplementation per day for 8 weeks among PCOS women had beneficial effects on metabolic profiles.

Cited by 34 publications

References 30 publications

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome

The Role of Zinc in Selected Female Reproductive System Disorders

Environmental determinants of polycystic ovary syndrome

Contact Info

Product

Resources

About