Effects of α-adrenoceptor agonists and antagonists on thyroid hormone secretion

Åhrén, Bo

doi:10.1530/acta.0.1080184

Cited by 19 publications

(3 citation statements)

References 16 publications

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“…These findings are accordant to the previous studies in mammals and birds [ 17 , 62 , 63 ], in which α 2A -adrenoceptors may play important roles in the CNS, including food intake [ 64 ], gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) release [ 30 , 65 , 66 ], sedation [ 67 ] and consolidation of working memory [ 68 ]. In the present study, cADRA2A is highly expressed in peripheral tissues, including the thyroid, which is in line with the detection in mice that the α 2 -adrenoceptors have been reported to regulate thyroid hormone secretion [ 68 , 69 , 70 ].…”

Section: Discussionsupporting

confidence: 90%

Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development

Jiang

Cao

Zhou

et al. 2022

Genes

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Adrenoceptors are suggested to mediate the functions of norepinephrine (NE) and epinephrine (EPI) in the central nervous system (CNS) and peripheral tissues in vertebrates. Compared to mammals, the functionality and expression of adrenoceptors have not been well characterized in birds. Here, we reported the structure, expression, and functionality of chicken functional α2A-adrenoceptor, named ADRA2A. The cloned chicken ADRA2A cDNA is 1335 bp in length, encoding the receptor with 444 amino acids (a.a.), which shows high amino acid sequence identity (63.4%) with its corresponding ortholog in humans. Using cell-based luciferase reporter assays and Western blot, we demonstrated that the ADRA2A could be activated by both NE and EPI through multiple signaling pathways, including MAPK/ERK signaling cascade. In addition, the mRNA expression of ADRA2A is found to be expressed abundantly in adult chicken tissues including thyroid, lung, ovary and adipose from the reported RNA-Seq data sets. Moreover, the mRNA expression of ADRA2A is also found to be highly expressed in the granulosa cells of 6–8 mm and F5 chicken ovarian follicles, which thus supports that ADRA2A signaling may play a role in ovarian follicular growth and differentiation. Taken together, our data provide the first proof that the α2A-adrenoceptor is functional in birds involving avian ovarian follicular development.

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Section: Discussionsupporting

confidence: 90%

Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development

Jiang

Cao

Zhou

et al. 2022

Genes

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“…Exogenous norepinephrine, like selective p-adrenoceptor agonists, has been shown to stimulate basal thyroid hormone secretion [1,5] and electrical activation of the right cervical sympathetic trunk has been shown to induce colloid droplet formation [4]. Furthermore, during anterograde degeneration of sympathetic varicosities after ganglionectomy, in the rat, the T» secretory response to TSH is inhibited [8], and sympathetic nerves seem to be of importance for thyroid growth [30].…”

Section: Discussionmentioning

confidence: 99%

Mechanism for the Inhibitory Action of 2-Deoxy-Glucose on Thyroid Hormone Secretion in the Mouse

Åhrén

Hedner²

1989

Neuroendocrinology

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The thyroid gland is richly innervated but the effects of activation of these nerves on thyroid hormone secretion are not yet established. In the present study, intravenous injection to mice of 2-deoxy-glucose (2-DG; 60 µmol/animal) was used to activate the autonomic nerves. The nerve activation occurs through the neuroglycopenia. We found that 2-DG inhibited the thyroid-stimulating hormone (TSH; 70 µU/animal)-induced thyroid hormone secretion, measured as release of radioiodine bound to anti-T₄ in radioiodine-pretreated mice. This inhibition by 2-DG was completely reversed by the α-adrenoceptor antagonist phentolamine but not affected by the β-adrenoceptor antagonist L-propranolol or the muscarinic receptor antagonist methylatropine. It is therefore concluded that neuroglycopenia-induced activation of the autonomic nerves inhibits TSH-induced thyroid hormone secretion by a mechanism that is reversed by phentolamine. It is suggested that it is mainly the adrenergic nerves that are involved in this action, and, consequently, that the function of the adrenergic nerves in thyroid physiology is to restrain the stimulatory action of TSH.

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“…An increase in circulating catecholamines stimulates basal thyroid hormone secretion. However, the precise roles played by adrenergic components of the thyroid innervation in the regulation of glandular function remain unclear [17]. In some patients, adverse events precede the onset of Graves' disease, suggesting that stress plays an important role as an initiating factor for the disease through catecholamines [2].…”

Section: Discussionmentioning

confidence: 99%

Graves' Disease Accompanied by Pheochromocytoma: Report of a Case

Kim

Lee

Shin

et al. 2009

J Korean Endocr Soc

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We present here a rare case of Graves' disease accompanied by pheochromocytoma, and the patient showed normal urine and serum levels of catecholamines and their metabolites. A 45-year-old woman was referred to our hospital for the evaluation of a right adrenal incidentaloma that was detected by chest computed tomography. She had been diagnosed with Graves' disease 1 month previously. She had no symptoms of pheochromocytoma such as hypertension or a history of hypertension attack. Two consecutive 24-hour urine samples were sent to the lab for measurement of the catecholamines, and both samples showed normal levels of metanephrine and vanillylmandelic acid (VMA). After right adrenalectomy was performed, the final pathological diagnosis was adrenal pheochromocytoma. This case suggests that the onset of Graves' disease may be associated with excess catecholamine secreted by a pheochromocytoma. In addition, although the conventional method for detecting pheochromocytoma is to identify an increase of the urine catecholamines,

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Effects of α-adrenoceptor agonists and antagonists on thyroid hormone secretion

Cited by 19 publications

References 16 publications

Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development

Characterization of Chicken α2A-Adrenoceptor: Molecular Cloning, Functional Analysis, and Its Involvement in Ovarian Follicular Development

Mechanism for the Inhibitory Action of 2-Deoxy-Glucose on Thyroid Hormone Secretion in the Mouse

Graves' Disease Accompanied by Pheochromocytoma: Report of a Case

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