Effects of α-eleostearic acid on asolectin liposomes dynamics: Relevance to its antioxidant activity

Sousa, Robson Simplicio de; Nogueira, Alessandro Oliveira de Moraes; Marques, Viviane Gobel; Clementin, Rosilene Maria; Lima, Vânia Rodrigues de

doi:10.1016/j.bioorg.2013.08.004

Cited by 20 publications

(1 citation statement)

References 66 publications

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“…Encapsulation of bioactives within lipid formulations often offers enhanced stability and protection, combined with superior biocompatibility and enhanced permeability, depending on the lipid composition and properties [ 8 , 9 ]. Among other phospholipids, asolectin, constituted by a mixture of lecithin, cephalin and phosphatidylinositol, saturated fatty acids, mono-unsaturated and poly-unsaturated fatty acids has been used to develop nano-microstructures such as fibers [ 10 , 11 , 12 , 13 ], hydrogels [ 14 ] and liposomes [ 7 , 15 ] for the encapsulation of bioactives [ 13 , 16 ]. In addition, asolectin components have also been proven to display antioxidant properties [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Phospholipid Fibers as Micro-Encapsulation and Antioxidant Matrices

et al. 2017

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Electrospun phospholipid (asolectin) microfibers were investigated as antioxidants and encapsulation matrices for curcumin and vanillin. These phospholipid microfibers exhibited antioxidant properties which increased after the encapsulation of both curcumin and vanillin. The total antioxidant capacity (TAC) and the total phenolic content (TPC) of curcumin/phospholipid and vanillin/phospholipid microfibers remained stable over time at different temperatures (refrigerated, ambient) and pressures (vacuum, ambient). 1H-NMR confirmed the chemical stability of both encapsulated curcumin and vanillin within phospholipid fibers. Release studies in aqueous media revealed that the phenolic bioactives were released mainly due to swelling of the phospholipid fiber matrix over time. The above studies confirm the efficacy of electrospun phospholipid microfibers as encapsulation and antioxidant systems.

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Section: Introductionmentioning

confidence: 99%

Electrospun Phospholipid Fibers as Micro-Encapsulation and Antioxidant Matrices

et al. 2017

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Mass Transfer Modeling of α‐Eleostearic Acid from Tung Oil Concentration by Low‐Temperature Crystallization

et al. 2020

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With the significant attention paid to α-eleostearic acid (α-ESA) in a variety of biologically beneficial effects, the demand for high-concentration products is increasing. A method of cryogenic separation to predict the mass variation of α-ESA from tung oil was established in this study. The results showed that the best α-ESA crystallization condition was À 20°C in ethanol, which implied a low energy consumption when compared with the common crystallization temperature of À 60°C. The α-ESA concentration in the liquid phase was reduced by 90.4% compared to tung oil, and most of the α-ESA in the solution was recovered by mass transfer. On the other hand, a mathematical model based on the diffusion reaction theory is used in mass variation prediction. The effects of temperature and time on the mass variation in α-ESA in solution crystallization were examined. The results showed that the proposed model could estimate the composition and total mass of winterized tung oil at R 2 = 0.974. The model was validated by experiments with an error of � 10%.[a] J.

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In Vitro Anti/Pro-oxidant Activities of R. ferruginea Extract and Its Effect on Glioma Cell Viability: Correlation with Phenolic Compound Content and Effects on Membrane Dynamics

et al. 2018

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Rapanea ferruginea antioxidant and antitumoral properties were not explored before in literature. This study aimed to investigate these biological activities for the R. ferruginea leaf extract and correlate them with its phenolic content and influence in biological membrane dynamics. Thus, in this study, anti/pro-oxidative properties of R. ferruginea leaf extract by in vitro DPPH and TBARS assays, with respect to the free radical reducing potential and to its activity regarding membrane free radical-induced peroxidation, respectively. Furthermore, preliminary tests related to the extract effect on in vitro glioma cell viability were also performed. In parallel, the phenolic content was detected by HPLC-DAD and included syringic and trans-cinnamic acids, quercetrin, catechin, quercetin, and gallic acid. In an attempt to correlate the biological activity of R. ferruginea extract and its effect on membrane dynamics, the molecular interaction between the extract and a liposomal model with natural-sourced phospholipids was investigated. Location and changes in vibrational, rotational, and translational lipid motions, as well as in the phase state of liposomes, induced by R. ferruginea extract, were monitored by Fourier-transform infrared spectroscopy, nuclear magnetic resonance, differential scanning calorimetry, and UV-visible spectroscopy. In its free form, the extract showed promising in vitro antioxidant properties. Free-form extract (at 1000µ g/mL) exposure reduced glioma cell in vitro viability in 40%, as evidenced by MTT tests. Pro-oxidant behavior was observed when the extract was loaded into liposomes. A 70.8% cell viability reduction was achieved with 500 µg/mL of liposome-loaded extract. The compounds of R. ferruginea extract ordered liposome interface and disorder edits a polar region. Phenolic content, as well as membrane interaction and modulation may have an important role in the oxidative and antitumoral activities of the R. ferruginea leaf extract.

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Effects of α-eleostearic acid on asolectin liposomes dynamics: Relevance to its antioxidant activity

Cited by 20 publications

References 66 publications

Electrospun Phospholipid Fibers as Micro-Encapsulation and Antioxidant Matrices

Electrospun Phospholipid Fibers as Micro-Encapsulation and Antioxidant Matrices

Mass Transfer Modeling of α‐Eleostearic Acid from Tung Oil Concentration by Low‐Temperature Crystallization

In Vitro Anti/Pro-oxidant Activities of R. ferruginea Extract and Its Effect on Glioma Cell Viability: Correlation with Phenolic Compound Content and Effects on Membrane Dynamics

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