Effects of α-tocopherol on lipid peroxidation and mitochondrial reduction of tetraphenyl tetrazolium in the rat brain

Villalobos, M.A.; Cruz, J. P. De La; Carrasco, T.; Smith-Agreda, J; Cuesta, Felipe Sánchez de la

doi:10.1016/0361-9230(94)90199-6

Cited by 22 publications

(10 citation statements)

References 20 publications

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“…Some components of virgin olive oil, specifically polyphenols and vitamin E, have clear antioxidant effects in some cells and tissues [32][33][34]. Although TBARS determination is a nondefinitive and inexact representation of lipid peroxidation in comparison with other methods, the percentage differences between groups represents the qualitative changes in Table 3 Mean values ± SEM for platelet and endothelium biomarkers in control rats and animals treated with virgin olive oil at 0.…”

Section: Discussionmentioning

confidence: 99%

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Correa

Muñoz‐Marín

Arrebola³

et al. 2007

Lipids

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We investigated how virgin olive oil (VOO) affected platelet and hypoxic brain damage in rats. Rats were given VOO orally for 30 days at 0.25 or 0.5 mL kg(-1) per day (doses A and B, respectively). Platelet aggregation, thromboxane B2, 6-keto-PGF(1alpha), and nitrites + nitrates were measured, and hypoxic damage was evaluated in a hypoxia-reoxygenation assay with fresh brain slices. Oxidative stress, prostaglandin E2, nitric oxide pathway activity and lactate dehydrogenase (LDH) activity were also measured. Dose A inhibited platelet aggregation by 36% and thromboxane B2 by 19%; inhibition by dose B was 47 and 23%, respectively. Virgin olive oil inhibited the reoxygenation-induced increase in lipid peroxidation (57% in control rats vs. 2.5% (P < 0.05) in treated rats), and reduced the decrease in glutathione concentration from 67 to 24% (dose A) and 41% (dose B). Brain prostaglandin E2 after reoxygenation was 306% higher in control animals, but the increases in treated rats were only 53% (dose A) and 45% (dose B). The increases in nitric oxide production (213% in controls) and activity of the inducible isoform of nitric oxide synthase (175% in controls) were both smaller in animals given VOO (dose A 84%; dose B 12%). Lactate dehydrogenase activity was reduced by 17% (dose A) and 42% (dose B). In conclusion, VOO modified processes related to thrombogenesis and brain ischemia. It reduced oxidative stress and modulated the inducible isoform of nitric oxide synthase, diminishing platelet aggregation and protecting the brain from the effects of hypoxia-reoxygenation.

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Section: Discussionmentioning

confidence: 99%

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Correa

Muñoz‐Marín

Arrebola³

et al. 2007

Lipids

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“…After VE supplementation has been observed an increase in intracellular concentrations of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), but the mechanisms of this VE-mediated effects are still not fully understood [12,13]. In addition, administration of VE reduces lipid peroxidation level, malonaldehyde concentration, and mitochondrial activity, which are important cellular sources of oxidant radicals [14][15][16].…”

Section: Vitamin Ementioning

confidence: 99%

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez

González-Castañeda

2006

Nutrition Research

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Alpha-lipoic acid and vitamin E have synergistic effects, as determined in models of oxidant radical lesions. This review summarizes recent findings showing that the combination of alpha-lipoic acid plus vitamin E has beneficial effects in reducing oxidative damage in ischemic or other oxidationrelated pathological events. Both antioxidants are common in the normal human diet and side effects are very rare. Therefore, alpha-lipoic acid and vitamin E can counteract oxidative processes and could have an important role in clinical medicine.

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“…Similarly, a-tocopherol, when administered hourly starting 1 hour before 1 hour of ischemia and continuing into a 2-hour period of reperfusion, decreased lipid peroxidation and mitochondrial dysfunction in the rat [Villalobos et al, 1994] and decreased infarct size in the gerbil [Hara et al, 1990a]. The effectiveness of these vitamins seems to depend on administration of adequate doses before the acute event.…”

Section: Antioxidantsmentioning

confidence: 89%

Potential therapeutic intervention following hypoxic-ischemic insult

Rosenberg

1997

Ment. Retard. Dev. Disabil. Res. Rev.

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Cell death caused by hypoxia‐ischemia appears to be due to multiple mechanisms causing lysis of cells, both by osmotic rupture and by calcium‐dependent activation of degradative processes, as well as apoptosis. In the case of osmotic and calcium‐dependent lysis, the triggering stimulus seems to be abnormal accumulation of glutamate in the extracellular space. In the case of apoptotic death, the triggering stimulus is unclear. Because activation of one or more death programs does not necessarily commit a cell to die, a therapeutic window exists in which it should be possible to intervene to prevent progression to cell death in many cells that are affected by an hypoxic‐ischemic episode. Several therapeutic approaches have emerged targeting various steps in the process set in motion by abnormal glutamate accumulation. In addition, other approaches need to be developed to block apoptotic cell death. The most efficacious forms of therapy will probably be those that are effective against all types of cell death triggered by hypoxia‐ischemia. This may be accomplished either by the use of multiple agents or by intervention targeting processes or intermediates shared by multiple mechanisms of cell death. MRDD Research Reviews 3:76–84, 1997. © 1997 Wiley‐Liss, Inc.

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Effects of α-tocopherol on lipid peroxidation and mitochondrial reduction of tetraphenyl tetrazolium in the rat brain

Cited by 22 publications

References 20 publications

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

Potential therapeutic intervention following hypoxic-ischemic insult

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