Effects of β-hydroxy-β-methyl butyrate on performance and carcass quality of feedlot steers

Koevering, M.T. Van; Dolezal, H. G.; Gill, Duane A.; Owens, F. N.; Strasia, C. A.; Buchanan, D. S.; Lake, R. P.; Nissen, Steven

doi:10.2527/1994.7281927x

Cited by 38 publications

(21 citation statements)

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“…Such a molecule indeed represents a direct homologue of ␤-hydroxy-␤-methylbutyrate (HMB), a leucine derivative, which has been shown to possess significant anabolic properties [43][44][45].…”

Section: Possible Relations Of This Metabolism To the Pharmacologicalmentioning

confidence: 99%

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

Kumpun

Girault

Dinan

et al. 2011

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Possible Relations Of This Metabolism To the Pharmacologicalmentioning

confidence: 99%

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

Kumpun

Girault

Dinan

et al. 2011

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Hmb Safety and Dosage In Animalsmentioning

confidence: 99%

“…These studies are discussed further below and demonstrate the lack of standardization in dosages and study methods used. For example, in several studies, HMB was freely accessible and served ad libitum (Gatnau et al, 1995;Van Koevering et al, 1994). In contrast, Wilson et al (2012) and Aversa et al (2011) have shown that this kind of experiment requires strict control of feed and HMB consumption by individual animals.…”

Section: Hmb Safety and Dosage In Animalsmentioning

confidence: 99%

Dietary supplementation of β‐hydroxy‐β‐methylbutyrate in animals – a review

Szcześniak

Ostaszewski

Fuller

et al. 2014

Animal Physiology Nutrition

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SummaryThe leucine metabolite b-hydroxy-b-methylbutyrate (HMB) has been studied by many researchers over the last two decades. In particular, the utility of HMB supplementation in animals has been shown in numerous studies, which have demonstrated enhanced body weight gain and carcass yield in slaughter animals; positive immunostimulatory effect; decreased mortality; attenuation of sarcopenia in elderly animals; and potential use in pathological conditions such as glucocorticoid-induced muscle loss. The aim of this study was to summarize the body of research on HMB supplementation in animals and to examine possible mechanisms of HMB action. Furthermore, while the safety of HMB supplementation in animals is well documented, studies demonstrating efficacy are less clear. The possible reasons for differences in these findings will also be examined.

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“…HMB is naturally produced in animals and humans from the amino acid leucine [27]. The first step in production of HMB is the reversible transamination of leucine to α-keto-isocaproate (KIC) by the enzyme branched chain amino acid transferase [28] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)

Wilson

Fitschen

Campbell

et al. 2013

Journal of the International Society of Sports Nutrition

146

141

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Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the use of beta-hydroxy-beta-methylbutyrate (HMB) as a nutritional supplement. The ISSN has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal muscle damage in trained and untrained populations. 2. If consuming HMB, an athlete will benefit from consuming the supplement in close proximity to their workout. 3. HMB appears to be most effective when consumed for 2 weeks prior to an exercise bout. 4. Thirty-eight mg·kg·BM-1 daily of HMB has been demonstrated to enhance skeletal muscle hypertrophy, strength, and power in untrained and trained populations when the appropriate exercise prescription is utilized. 5. Currently, two forms of HMB have been used: Calcium HMB (HMB-Ca) and a free acid form of HMB (HMB-FA). HMB-FA may increase plasma absorption and retention of HMB to a greater extent than HMB-CA. However, research with HMB-FA is in its infancy, and there is not enough research to support whether one form is superior. 6. HMB has been demonstrated to increase LBM and functionality in elderly, sedentary populations. 7. HMB ingestion in conjunction with a structured exercise program may result in greater declines in fat mass (FM). 8. HMB’s mechanisms of action include an inhibition and increase of proteolysis and protein synthesis, respectively. 9. Chronic consumption of HMB is safe in both young and old populations.

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Effects of β-hydroxy-β-methyl butyrate on performance and carcass quality of feedlot steers

Cited by 38 publications

References 0 publications

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

Dietary supplementation of β‐hydroxy‐β‐methylbutyrate in animals – a review

International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)

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