Effects on Bone Repair of Osteotomy With Drills or With Erbium, Chromium: Yttrium‐Scandium‐Gallium‐Garnet Laser: Histomorphometric and Immunohistochemical Study

Esteves, Jônatas Caldeira; Faloni, Ana Paula de Souza; Macedo, Paula Delello; Nakata, Patrícia Borges; Marcantonio, Rosemary Adriana Chiérici; Intini, Giuseppe; Marcantônio, Élcio

doi:10.1902/jop.2015.150406

Cited by 13 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemically, the increase of OCN expression was confirmed in granulation tissue at 2 weeks. The result was consistent with a previous report that showed a significant increase of OCN in granulation tissue at lased sites, compared to bur-drilled sites, following osteotomy [21]. Therefore, upregulated gene expressions of osteogenic differentiation markers in granulation tissue are evidence of enhanced new bone formation in laser-treated bone.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling

Ohsugi

Aoki

Mizutani

et al. 2018

Journal of Biophotonics

View full text Add to dashboard Cite

The Er:YAG laser is currently used for bone ablation. However, the effect of Er:YAG laser irradiation on bone healing remains unclear. The aim of this study was to investigate bone healing following ablation by laser irradiation as compared with bur drilling. Rat calvarial bone was ablated using Er:YAG laser or bur with water coolant. Er:YAG laser effectively ablated bone without major thermal changes. In vivo micro‐computed tomography analysis revealed that laser irradiation showed significantly higher bone repair ratios than bur drilling. Scanning electron microscope analysis showed more fibrin deposition on laser‐ablated bone surfaces. Microarray analysis followed by gene set enrichment analysis revealed that IL6/JAK/STAT3 signaling and inflammatory response gene sets were enriched in bur‐drilled bone at 6 hours, whereas the E2F targets gene set was enriched in laser‐irradiated bone. Additionally, Hspa1a and Dmp1 expressions were increased and Sost expression was decreased in laser‐irradiated bone compared with bur‐drilled bone. In granulation tissue formed after laser ablation, Alpl and Gblap expressions increased compared to bur‐drilled site. Immunohistochemistry showed that osteocalcin‐positive area was increased in the laser‐ablated site. These results suggest that Er:YAG laser might accelerate early new bone formation with advantageous surface changes and cellular responses for wound healing, compared with bur‐drilling.

show abstract

Section: Discussionsupporting

confidence: 93%

Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling

Ohsugi

Aoki

Mizutani

et al. 2018

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…The use of Er,Cr:YSGG laser has a great potential in the hard tissues surgery; indeed Er,Cr:YSGG laser enables efficient resection of the maxilla without using conventional rotary instruments, as the laser produces a clear and precise cut with minimal injury to contiguous hard and soft tissues [6, 20, 23, 42, 43]. …”

Section: Discussionmentioning

confidence: 99%

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Mauceri

Panzarella

Maniscalco

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

Introduction The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.

show abstract

“…Burs/drills vs lasers: Evaluation of evidence value in comparative in vivo studies [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] suffers mainly from the wide range of different laser-systems used (Er:YAG, Er,Cr:YSGG, CO2, femtolaser), laser-light delivery (free beam, optic fi bers) and lack of standardized protocols regarding focus-spot energy-density, pulse-rate and pulse-frequency used. There is not even moderate evidence (EV: 0,5, Table 1) for lasers to provide superior cutting performance on micromorphologic, microscopic and clinical level in vivo and most authors point out thermal damages and thermal bonenecrosis in histologic investigations.…”

Section: Group 3 (Experimental Studies In Vivo)mentioning

confidence: 99%

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Troedhan¹,

Mahmoud²,

Wainwright³

et al. 2017

Int J Oral Craniofac Sci

View full text Add to dashboard Cite

Background: New tools for bone-cutting were introduced to oral and maxillofacial surgery in the last decade, such as lasers and piezotomes. Purpose: to evaluate most recent evidence, when surgical procedures performed with drills or burs are compared with laser-and/or piezotome-surgical procedures in experimental and clinical studies and to assess possible advantages of their use in daily practice. Methods: a systematic search of various medical databases with specifi c keywords was performed, excluding studies published before 2006 for their possible invalidity by technological progress. Systematic reviews were assigned to Group 1, experimental studies ex vivo to Group 2, in vivo to Group 3 and clinical studies to Group 4. All studies in each of the groups 2-4 were appraised regarding their evidence, starting with a value of 0 for no evidence of advantages of lasers and/or piezotomes compared to rotary instruments, 1 for moderate evidence with verifi ed clinical impact and 2 for strong evidence and signifi cant clinical impact and statistically processed for their Evidence Value (EV) in each group and their Overall mean Evidence Value (OmEV). Results: 129 studies were fi nally included for evaluation. Two systematic reviews concluded lack of evidence for lasers to be advantageous over burs/drills. Nine reviews for piezotomes reveal strong evidence piezotome-surgery to signifi cantly reduce morbidity and to enhance soft-tissue preservation. Comparative experimental and clinical studies of burs/drills vs lasers revealed a low EV in Group 2 (EV:0,8), Group 3 (EV:0,5) and Group 4 (EV:0,5) with an OmEV of 0,6. Comparative studies burs/drills vs piezotomes resulted in a signifi cant EV in all groups (

show abstract

Effects on Bone Repair of Osteotomy With Drills or With Erbium, Chromium: Yttrium‐Scandium‐Gallium‐Garnet Laser: Histomorphometric and Immunohistochemical Study

Abstract: The repair process of osteotomies created by the Er,Cr:YSGG laser, despite producing thermal damage to bone tissue, is comparable to that with conventional drills.

Cited by 13 publications

References 33 publications

Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling

Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Cutting bone with drills, burs, lasers and piezotomes: A comprehensive systematic review and recommendations for the clinician

Contact Info

Product

Resources

About