Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS)

Watts, Gerald F.; Lewis, Barry; Lewis, Eve S.; Coltart, D J; Smith, Larry J.; Swan, A V; Brunt, J. N. H.; Mann, Jim

doi:10.1016/0140-6736(92)90863-x

Cited by 785 publications

(251 citation statements)

References 23 publications

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“…Nonetheless, even moderate reductions in serum cholesterol levels will have quite substantial effects on lowering the risk of ischaemic heart disease, as reviewed by Law et al (1994). Dietary interventions have effects on both cholesterol levels and health (Hjermann et al, 1981;Ornish et al, 1990;Watts et al, 1992;Traeden et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Will recommended changes in fat and fibre intake affect cholesterol absorption and sterol excretion? An ileostomy study

2000

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Objective: To study cholesterol absorption and excretion in ileostomy subjects with different intakes of saturated fat and dietary ®bre. Design: Short-term experimental study, with four controlled diets in repeated measurements. Setting: Out-patients at metabolic-ward kitchen. Subjects: Nine healthy volunteers with conventional ileostomy after colectomy because of ulcerative colitis. Interventions: Four diet periods, each of 3 days duration: high saturated fat and low dietary ®bre (STAND); reduced saturated fat (RESAT); high saturated fat and high ®bre (FATFIB); and reduced saturated fat and high ®bre (RESATFIB). Main outcome measures: Absorption of cholesterol, and ileal excretion of cholesterol, bile acids, fat and energy. Differences between diets evaluated with Friedman's two-way analysis of variance by rank sum with Bonferroni adjustment, and post hoc differences assessed by rank sum comparison. Results: RESAT and RESATFIB reduced fractional cholesterol absorption by 7% and 10%; RESATFIB and FATFIB increased net cholesterol excretion by 46% and 54% respectively. Further, RESATFIB increased net sterol excretion by 18%, all compared to STAND (P`0.05 for all). All three intervention diets contained more phytosterols than STAND (P`0.05), and the phytosterol content was inversely correlated to fractional cholesterol absorption (r 7 0.77, P`0.01). Conclusions: Current nutrition recommendations to reduce saturated fat and increase dietary ®bre affect sterol excretion additively. The effect on cholesterol absorption might be partly explained by the content of dietary plant sterols. Sponsorship: Supported by grants from the Gothenburg Medical Society, grant numbers 94a086 and 99a082, and by the University of Gothenburg.

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Section: Introductionmentioning

confidence: 99%

Will recommended changes in fat and fibre intake affect cholesterol absorption and sterol excretion? An ileostomy study

2000

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“…The primary aim of this study was to determine the response, in terms of dietary practices, of post MI patients to a programme of dietary counselling. The programme was based on existing evidence for benefit from specific dietary changes (fat, fruit and vegetables, oily fish and body weight), all of which feature in the Scottish Dietary Targets (Burr et al, 1989;Singh et al, 1992;Watts et al, 1992;De Lorgeril et al, 1994;Singh et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…These are: increased oily fish (Burr et al, 1989), increased fruit and vegetable consumption (Singh et al, 1992), modification of dietary fat intake (Watts et al, 1992;De Lorgeril et al, 1994) and weight loss (Singh et al, 1996). There is clinical trial evidence for each of these measures individually being effective in secondary prevention.…”

Section: Introductionmentioning

confidence: 99%

A transferable programme of nutritional counselling for rehabilitation following myocardial infarction: a randomised controlled study

et al. 2004

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Objective: To evaluate the response to simple innovative dietary counselling in post myocardial infarction patients. Design: Randomised controlled trial. Setting: Cardiac rehabilitation programmes of two acute hospitals in Lanarkshire, Scotland. Patients: A total of 69 men and 29 women aged 35-75 y who survived acute myocardial infarction and participated in the cardiac rehabilitation programmes of the study hospitals between 1st September 1997 and 1st August 1998. Results: At 12 weeks follow-up, diet composition had improved significantly in intervention subjects, but no such change was evident in the control group. The target of five portions of fruit and vegetables per day was achieved by 65% of intervention subjects but only 31% of control subjects (P¼0.004). Between-group differences in food intakes were no longer evident at 1 y. Diet composition did however remain in line with current dietary targets in intervention subjects. Conclusion: Compared to conventional cardiac rehabilitation, this intervention, focused on targets known to improve mortality, improved diet in post myocardial infarction patients. However, a more sustained programme is required to maintain improvements. Delivery of the intervention was expensive and further research is required to determine the feasibility of a group approach using the same package.

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“…Também no estudo STARS (St Thomas Atherosclerosis Regression Study) em que pacientes com características semelhantes aos nossos foram avaliados, o grupo que recebeu rigoroso tratamento dietético hipogorduroso associado a colestiramina apresentou reduções de colesterol total de 25% e de LDL-colesterol de 36%, discretamente superiores aos verificados em nosso trabalho 11 .…”

Section: Discussionunclassified

Terapia combinada de colestiramina e inibidores da HMG-CoA redutase na prevenção secundária da doença coronária

Novazzi¹,

Pinto²,

Auriemo³

et al. 1998

Arq. Bras. Cardiol.

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Purpose -To evaluate lipid profile changes associated with cholestyramine addition in hypercholesterolemic patients with established coronary heart disease under treatment with HMG-CoA reductase inihibtors that had not achieved the ideal value of LDL-cholesterol.Methods -Twenty patients with coronary heart disease, (12 Portadores de hipercolesterolemia e doença arterial coronária (DAC), quando submetidos a tratamento dietético e farmacológico hipolipemiante, apresentam menor recorrência de eventos coronários, redução da mortalidade cardiovascular e de mortalidade total 1,2 .

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Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS)

Cited by 785 publications

References 23 publications

Will recommended changes in fat and fibre intake affect cholesterol absorption and sterol excretion? An ileostomy study

Will recommended changes in fat and fibre intake affect cholesterol absorption and sterol excretion? An ileostomy study

A transferable programme of nutritional counselling for rehabilitation following myocardial infarction: a randomised controlled study

Terapia combinada de colestiramina e inibidores da HMG-CoA redutase na prevenção secundária da doença coronária

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