Effects on reproduction in Fischer 344 rats exposed to ethylene oxide by inhalation for one generation*1

Snellings, William M.; Zelenak, Janice P.; Weil, Carrol S.

doi:10.1016/0041-008x(82)90267-8

Cited by 32 publications

(21 citation statements)

References 9 publications

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“…For chemicals of this kind, levels which are safe for the pregnant worker will also be safe for her conceptus. The results reported in this communication are consistent with those of the study by Snellings et a1 (7), in which fetotoxic but not teratogenic effects were seen in rats exposed to 100 ppm of ethylene oxide. In contrast LaBorde & Kimmel (5) found, at doses that were not maternally toxic, that intravenously injected ethylene oxide induced a significant incidence of skeletal malformations in mice.…”

Section: Discussionsupporting

confidence: 83%

“…Because of concern for the intravenous exposure of humans to ethylene oxide leaching from ethylene oxide-sterilized medical devices, LaBorde & Kimmel (5) injected pregnant mice intravenously during four 3-d segments of gestation. Ethylene oxide was clearly teratogenic on days [6][7][8] of gestation and caused primarily skeletal defects; the frequency of malformations was also increased in groups treated on day 8-10 and 10-12.…”

Section: Resinsmentioning

confidence: 94%

“…Snellings e t a1 (7) reported no developmental defects when pregnant rats were exposed to 0, 10, 33, or 100 pprn (0, 18, 60, or 180 mg/m3, respectively) of ethylene oxide on days 6-15 of gestation, although the body weights of fetuses were reduced at 100 ppm. In a reproduction study, Snellings et a1 (7) exposed both male and female rats to ethylene oxide for 12 weeks before breeding and continued exposing females through day 19 of gestation.…”

Section: Resinsmentioning

confidence: 99%

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Reproductive-toxicologic assessment of the epoxides ethylene oxide, propylene oxide, butylene oxide, and styrene oxide.

Hardin¹,

Niemeier²,

Sikov³

et al. 1983

Scand J Work Environ Health

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PL. Reproductive-toxicologic assessment of the epoxides ethylene oxide, propylene oxide, butylene oxide and styrene oxide. Scand j work environ health 9 ((1983) 94-102. Ethylene oxide (CAS no 75-21-8), propylene oxide (CAS no 75-56-9), butylene oxide (CAS no 106-88-71, and styrene oxide (CAS no 96-09-3) were tested for teratogenic activity by inhalation exposure of rats and rabbits. Ethylene oxide and propylene oxide were tested at only one concentration in both species (150 ppm for ethylene oxide and 500 ppm for propylene oxide). Butylene oxide was tested at 250 and 1,000 ppm in both species, while styrene oxide was tested at 100 ppm in rats and 15 and 50 ppm in rabbits. For each of these four epoxides, the acute toxicity was similar for pregnant and nonpregnant rats. Styrene oxide was the most toxic in both species, and rabbits were more sensitive than rats. Rats exposed to propylene oxide for 7 hld, 5 dlweek for three weeks before breeding had a significant reduction in the number of corpora lutea. Fetal mortality was not increased, but significantly fewer mated rats were found pregnant following gestational exposure to styrene oxide, a finding suggesting preimplantation loss. In rabbits exposed to styrene oxide, the number of resorptions per litter was increased in a concentrationrelated manner, but differences were not statistically significant. Fetal examinations revealed evidence of fetotoxicity with all four epoxides. There was no overt teratogenic activity, but a number of minor morphologic aberrations were detected.

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Section: Discussionsupporting

confidence: 83%

Section: Resinsmentioning

confidence: 94%

Section: Resinsmentioning

confidence: 99%

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Reproductive-toxicologic assessment of the epoxides ethylene oxide, propylene oxide, butylene oxide, and styrene oxide.

Hardin¹,

Niemeier²,

Sikov³

et al. 1983

Scand J Work Environ Health

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“…Experimentalmente se ha comprobado que el óxido de etileno produce alteraciones tanto embrionarias como fetales 24,46 , y disminuye la función reproductora 45 . Aunque la información a nivel humano es muy escasa, hay que destacar el estudio realizado por Hemminki y col. 17 en Finlandia.…”

Section: Efectos Mutagénicos Cancerígenos Teratogénicos Y De La Fununclassified

Aspectos toxicológicos de la exposición al óxido de etileno

Marín

Gallén

1987

Rev. Saúde Pública

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PRAT-MARÍN, A. & SANZ-GALLÉN, P. Aspectos toxicológicos de la exposición al óxido de etileno. Rev. Saúde públ., S. Paulo, 21:523-8, 1987. RESUMEN:En este trabajo se revisan los principales riesgos de la utilización del óxido de etileno como agente esterilizante del material médico-quirúrgico. Resaltando los efectos tóxicos, mutagénicos, teratogénicos y cancerígenos como los más importantes, enfatizando en la necesidad de adoptar medidas de prevención para controlar dichos riesgos. DESCRIPTORES:Óxido de etileno, toxicidad. Esterilización. Riesgo.* Departamento de Salud Pública y Legislación Sanitaria da Universidad de Barcelona -Avda. Diagonal, s/n. -08028 -Barcelona, España. INTRODUCCIÓNEl empleo de diferentes substancias con una finalidad industrial o sanitaria, puede comportar riesgos de diversa naturaleza que interesa conocer adecuadamente. El óxido de etileno es un gas que, a temperatura y presión normales, tiene una densidad superior a la del aire y es soluble en agua. Por su estructura química (Figura) pertenece al grupo de los epoxy compuestos. Este oxileno o enlace epoxy es extremadamente reactivo con todo tipo de material que entra en contacto con él. El óxido de etileno actúa combinándose con los grupos carboxilo, amino, sulfhidrilo e hidroxilo de las proteínas bacterianas. Para evitar hipoté-ticas inflamaciones se utiliza generalmente mezclado con gases inertes; cuando se le comparan sus propiedades esterilizantes con las de otros agentes químicos (óxido de propileno, formalina, glicoles, etilenimina, halóge-nos, glutaraldehido, etc.), es el mas efectivo y el menos peligroso de todos ellos. Actualmente es una de las 25 substancias químicas mas utilizadas mundialmente 37,43 .Sin embargo, en los últimos años se ha cuestionado su uso, como resultado de diversas investigaciones, en las que, se le imputan unos posibles efectos mutagénicos, teratogénicos y cancerígenos 13,20,43 .Debido a su amplia utilización en el medio hospitalario como agente esterilizante del material médico-quirúrgico (Tabla 1), efectuamos una revisión y puesta al día de esta incipiente temática.

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“…Maternal neglect resulting from excessive sedation of rat mothers was considered to have affected the pup survival; the effect was more pronounced during the first 4 days of lactation. Snellings et al (1982) concluded that "there were no treatment-related adverse effects on survival or growth rate of the Fla generation during lactation." The authors found the average weanling body weight to be 24.4 ± 2.9 g (males) and 24.1 ± 3.1 g (females) in Control I, 25.8 ± 3.9 g (males) and 24.8 ± 3.1 g (females) in Control n, and 23.6 ± 5.3 g (males) and 21.8 ± 4.3 g (females) in the high-dose group.…”

Section: Arguments In Favor Of Cullingmentioning

confidence: 99%