Effektivnost' i bezopasnost' dvukhfaznogo insulina Aspart 30 po dannym lecheniya patsientov s sakharnym diabetom 2 tipa v Rossiyskoy Federatsii: rezul'taty mnogotsentrovogo nablyudatel'nogo issledovaniya

Shestakova, Marina Vladimirovna; Lebedev, N. N.; Ping, E Zhin

doi:10.14341/2072-0351-5998

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…It should be noted that even with the compensation of carbohydrate metabolism, the development of DR continues. [5][6][7][8][9]. To date, the key role of endothelial dysfunction in the occurrence and progression of DR has been proven [10,11].…”

Section: Abstract: Experimental Diabetic Retinopathy; Endothelial Dys...mentioning

confidence: 99%

Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction

Sirman

Preis

Savytskyi

2021

J Educ Health Sport

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Diabetic retinopathy (DR) according to the WHO is the main cause of decreased vision and blindness due to diabetes. The aim of the study: to compare the effectiveness of correction of vasoconstriction in experimental diabetic retinopathy under the influence of different methods of correction. Our results indicate a violation of the functional state of blood vessels on the 30th day of experimental diabetic retinopathy with subsequent progression of pathological changes on the 60th and 180th day of the study, as evidenced by a significant increase in endothelin-1 in the 2nd group (p <0.001), most pronounced in the 3rd stage.In the analysis of data of group №3 it was found that the correction of pathological conditions with hypoglycemic agents has a positive effect, but does not allow to significantly correct pathologically increased levels of endothelin-1, which indicates the need for additional correction tools other than hyperglycemia.The results of group 4 indicate that the involvement of a donor of nitric oxide and aflibercept in the correction of diabetic retinopathy corrects the level of the studied marker, the most pronounced effect is observed on the 180th day of the experiment, but normative values can not be achieved. It was found that in the 5th group, in which the correction of the simulated pathological condition was performed by reducing hyperglycemia, the introduction of aflibercept and bromfenac gives positive results, but less pronounced than in the 4th group, where L-arginine solution was added to the complex correction. .It was found that rats of group 6, which simulated diabetic retinopathy with subsequent correction of hyperglycemia, administration of aflibercept, L-carnitine and bromfenac have a pronounced effectiveness of the proposed method of correction compared to previous methods, the level of vasoconstriction stage and continues to recover in the following stages of the experiment, but does not reach the normative values. The obtained data suggest that the method of correction selected in group 7, which includes reduction of hyperglycemia, administration of aflibercept, solution of L-arginine and citicoline is most effective for normalizing vascular tone and structural and functional state of the endothelium.

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Section: Abstract: Experimental Diabetic Retinopathy; Endothelial Dys...mentioning

confidence: 99%

Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction

Sirman

Preis

Savytskyi

2021

J Educ Health Sport

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About Understanding of the Official Document According to the Articles 292 and 327 of the Criminal Code of the Russian Federation for the Purpose of Qualifying Crimes

Баландин

2020

Juridical Journal of Samara University

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The article identifies and reveals the Corpus delicti of forgery (Article 292 of the Criminal Code) and the manufacture of counterfeit documents (Article 327 of the Criminal Code). The article concludes that there is a differentiated understanding of the official document for the composition of crimes from different chapters of the Criminal Code of the Russian Federation. The article concludes that there is a differentiated understanding of the official document for the crimes from different chapters of the Criminal Code of the Russian Federation. The legal content of the subject of the crime is determined by the specifics of protected public relations that are damaged, as well as other signs of the crime. It is necessary to update the understanding of forged documents in connection with the introduction of official electronic documents and private documents. It is concluded that for the purposes of proper qualification of crimes, the signs of the subject of official forgery (Article 292 of the Criminal Code) and the production of forged documents (Article 327 of the Criminal Code) should be fixed in the notes to the relevant articles of the Criminal Code, taking into account the specifics of the specific object of crimes.

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Effektivnost' i bezopasnost' dvukhfaznogo insulina Aspart 30 po dannym lecheniya patsientov s sakharnym diabetom 2 tipa v Rossiyskoy Federatsii: rezul'taty mnogotsentrovogo nablyudatel'nogo issledovaniya

Cited by 2 publications

References 14 publications

Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction

Research of changes in the level of endothelin-1 in experimental diabetic retinopathy. comparison of methods of correction

About Understanding of the Official Document According to the Articles 292 and 327 of the Criminal Code of the Russian Federation for the Purpose of Qualifying Crimes

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