Efferent connections of lobule IX of the posterior cerebellar cortex in the rabbit — some functional considerations

Paton, Julian F. R.; Noce, A. La; Sykes, R. M.; Sebastiani, Laura; Bagnoli, Paola; Ghelarducci, Brunello; Bradley, David J.

doi:10.1016/0165-1838(91)90045-5

Cited by 43 publications

(24 citation statements)

References 33 publications

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“…The present data indicate that these areas mainly receive from the CVN relatively simple signals regarding head position or head velocity, at least during rotations in vertical planes. STC behavior and other complex responses were not obvious in a large majority of CVN neurons, despite the fact that this region receives considerable inputs from the uvula and nodulus in addition to projecting to these regions (Shojaku et al 1987;Patton et al 1991). An exception is the group of neurons that exhibited a large augmentation in response gain with increasing stimulus frequency, and which had response phases near stimulus velocity when low-frequency tilts were performed that lagged to near stimulus position during high-frequency rotations.…”

Section: Discussionmentioning

confidence: 97%

Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy

et al. 2008

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Although many previous experiments have considered the responses of vestibular nucleus neurons to rotations and translations of the head, little data are available regarding cells in the caudalmost portions of the vestibular nuclei (CVN), which mediate vestibulo-autonomic responses among other functions. This study examined the responses of CVN neurons of conscious cats to rotations in vertical planes, both before and after a bilateral vestibular neurectomy. None of the units included in the data sample had eye movement-related activity. In labyrinth-intact animals, some CVN neurons (22%) exhibited graviceptive responses consistent with inputs from otolith organs, but most (55%) had dynamic responses with phases synchronized with stimulus velocity. Furthermore, the large majority of CVN neurons had response vector orientations that were aligned either near the roll or vertical canal planes, and only 18% of cells were preferentially activated by pitch rotations. Sustained head-up rotations of the body provide challenges to the cardiovascular system and breathing, and thus the response dynamics of the large majority of CVN neurons were dissimilar to those of posturally-related autonomic reflexes. These data suggest that vestibular influences on autonomic control mediated by the CVN are more complex than previously envisioned, and likely involve considerable processing and integration of signals by brainstem regions involved in cardiovascular and respiratory regulation. Following a bilateral vestibular neurectomy, CVN neurons regained spontaneous activity within 24 h, and a very few neurons (<10%) responded to vertical tilts <15° in amplitude. These findings indicate that nonlabyrinthine inputs are likely important in sustaining the activity of CVN neurons; thus, these inputs may play a role in functional recovery following peripheral vestibular lesions.

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Section: Discussionmentioning

confidence: 97%

Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy

et al. 2008

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“…By way of fastigial projections to intralaminar thalamus (Okumura et al, 2001;Gonzaloruiz and Leichnetz, 1990;Larsell et al, 1972;Melik-Musyan and Fanardjyan, 1998), and pedunculopontine tegmental nucleus (PPN; Hazrati and Parent, 1992), the vermis could provide behavioral state-dependent modulation of a critical gaiting region for BG, STN, and PPN (Kimura et al, 2004). The PPN issues collaterals back to the fastigial nucleus (Ruggiero et al, 1997) and is thought to be critical to the effects of fastigial electrical stimulation-evoked cerebrovascular waves coupled with EEG desynchronization (Fadiga et al, 1968;Golanov et al, 2000;Paton et al, 1991).…”

Section: Discussionmentioning

confidence: 97%

Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis

Anderson

Lowen

Renshaw

2006

Journal of Neuroscience Methods

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“…Anatomical tracing studies show that the pons, and particularly the parabrachial complex, is a target for descending inputs from the forebrain, hypothalamus, midbrain and cerebellum and also indirectly for reflex afferent inputs that arise from pulmonary and airway receptors, etc. Moga, Herbert, Hurley, Yasui, Gray & Saper, 1990; Allen, Saper, Hurley & Cechetto, 1991;Paton et al 1991). The parabrachial complex also has the appropriate reciprocal anatomical connections with the medulla to effect changes in both respiratory and cardiovascular activity (Saper & Loewy, 1980;Fulwiler & Saper, 1984; Krukoff, Harris & Jhamandas, 1993).…”

mentioning

confidence: 99%

Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anaesthetized rat.

Lara

Parkes

Silva-Carvhalo

et al. 1994

The Journal of Physiology

113

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1. In order to assess the importance of the parabrachial nuclei in modulating cardiorespiratory activity, electric current or microinjections of glutamate were used to stimulate discrete regions of the parabrachial nuclei in anaesthetized rats. 2. Stimulation of cell bodies in the medial region of the parabrachial nuclei and in the Kolliker-Fuse nuclei, caused an expiratory facilitatory response. This consisted mainly of a decrease in respiratory rate as measured by observing phrenic nerve activity. 3. Stimulation of cell bodies in the lateral region of the parabrachial nuclei caused an inspiratory facilitatory response. This consisted mainly of an increase in respiratory rate. 4. At the majority of sites (16 out of 20) where changes in respiratory rate were elicited by glutamate injection or electrical stimulation an increase in blood pressure was observed. The coexistence of increases in blood pressure and heart rate indicates the presence of inhibition of the heart rate component of the baroreflex and/or an increase in cardiac sympathetic drive. 5. The expiratory facilitatory response was not evoked reflexly by the rise in blood pressure since it was still present after administration of guanethidine, which abolished the rise in blood pressure. 6. The interactions between the parabrachial nuclei and the medullary respiratory complex in eliciting these changes are discussed.

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Efferent connections of lobule IX of the posterior cerebellar cortex in the rabbit — some functional considerations

Cited by 43 publications

References 33 publications

Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy

Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy

Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis

Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anaesthetized rat.

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