Efferocytosis and Lung Disease

McCubbrey, Alexandra L.; Curtis, Jeffrey L.

doi:10.1378/chest.12-2413

Cited by 105 publications

(99 citation statements)

References 62 publications

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“…Clearance of apoptotic cells by phagocytes is likely important for preventing the development of asthma (34,35). Airway epithelial cells also recently have been shown to engulf apoptotic epithelial cells and secrete anti-inflammatory cytokines, resulting in attenuated airway inflammation (36).…”

Section: Discussionmentioning

confidence: 99%

Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant–Induced Th2 Responses

Miki

Nakahashi-Oda

Sumida

et al. 2015

The Journal of Immunology

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Aluminum salt (alum) has been widely used for vaccinations as an adjuvant. Alum not only enhances immunogenicity but also induces Th2 cell immune responses. However, the mechanisms of how alum enhances Th2 cell immune responses have been controversial. In an experimental allergic airway inflammation model, in which alum in conjunction with OVA Ag was i.p. injected for immunization, we found that apoptotic cells and inflammatory dendritic cells (iDC) expressing CD300a, an inhibitory immunoreceptor for phosphatidylserine (PS), significantly increased in number in the peritoneal cavity after the immunization. In contrast, apoptotic cells and iDCs were scarcely observed in the peritoneal cavity after injection of OVA alone. In CD300a-deficient mice, eosinophil infiltration in bronchoalveolar lavage fluid, serum IgE levels, and airway hyperreactivity were significantly decreased after immunization with alum plus OVA compared with wild-type mice. In vitro, iDCs purified from CD300a-deficient mice after the immunization induced significantly less IL-4 production from OT-II naive CD4+ T cells after coculture with OVA Ag. CD300a expressed on iDCs bound PS on apoptotic cells in the peritoneal cavity after injection of OVA plus alum. Blocking CD300a interaction with PS by injection of a neutralizing anti-CD300a Ab resulted in inhibition of the development of allergic airway inflammation. These results suggest that CD300a is involved in alum-induced Th2 skewing.

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Section: Discussionmentioning

confidence: 99%

Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant–Induced Th2 Responses

Miki

Nakahashi-Oda

Sumida

et al. 2015

The Journal of Immunology

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“…Endothelial dysfunction is one of the earliest vascular changes in atherosclerosis and proposed to actively promote atherogenesis (Gimbrone and García-Cardeña 2016). Emphysema formation in COPD patients is associated with endothelial cell stress and cell death in the pulmonary capillaries, leading to impaired vessel function (McCubbrey and Curtis 2013;Takahashi et al 2012). Endothelial damage may actively contribute to the pathogenesis of COPD (Barr 2011).…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Benedikter

Wouters

Savelkoul

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes). All original research articles were included and reviewed. Fifty articles were identified, most of which investigated the effect of respiratory exposures on EV release in vitro (25) and/or on circulating EV in human plasma (24). The majority of studies based their main observations on the relatively insensitive scatter-based flow cytometry of EV (29). EV induced by respiratory exposures were found to modulate inflammation (19), thrombosis (13), endothelial dysfunction (11), tissue remodeling (6), and angiogenesis (3). By influencing these processes, EV may play a key role in the development of cardiovascular diseases and chronic obstructive pulmonary disease and possibly lung cancer and allergic asthma. The current findings warrant additional research with improved methodologies to evaluate the contribution of respiratory exposure-induced EV to disease etiology, as well as their potential as biomarkers of exposure or risk and as novel targets for preventive or therapeutic strategies.

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“…В настоящее время идентифицировано не менее двенадцати рецепторов PS, участвующих в эф-фероцитозе, из которых наиболее изучены BAI (brain-specific angiogenesis inhibitor 1), TAM (Tyro3-Axl-Mer), TIM (T cell immunoglobulin domain), рецепторы стабилина и CD300 [61]. В отличие от циркулирующих моноцитов, DC и тканевых макрофагов альвеолярные макрофаги обладают многочисленными рецепторами, распознающими апоптотические клетки, и чрезвычайно высокой чувствительностью к апоптотическим клеткам в альвеолярном пространстве [55].…”

Section: эффероцитоз как основной механизм физиологического снижения unclassified

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

Абатуров

Никулина

2021

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У статті на підставі літературних джерел продемонстрована роль клітинних реакцій у розвитку імунної відповіді при пневмонії, спричиненої Staphylococcus aureus. Описані механізми взаємодії Staphylococcus aureus з образ-розпізнавальними рецепторами епітеліоцитів респіраторного тракту, такими як хемосенсорні смакові рецептори, рекрутування та активації макрофагів, що забезпечують ефективний саногенез від стафілококової інфекції. Показані імуномодулююча роль ефероцитозу й основні варіанти клітинної загибелі, що регулюють запалення.

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Efferocytosis and Lung Disease

Cited by 105 publications

References 62 publications

Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant–Induced Th2 Responses

Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant–Induced Th2 Responses

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 5)

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