Efferocytosis in Retinoblastoma

Abstract

Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy. Effective efferocytosis can be conceptualized for new pharmacodynamics application for anti-cancer drugs. We present a rare case of retinoblastoma with efferocytosis in retinal pigment epithelium and interesting apoptotic changes.

A rare case of lens neovascularisation in retinoblastoma

“…Few vesicular cells along with basophilic undifferentiated cells and occasional apoptotic bodies were noted. 5 Neovascularization of lens was also documented in H&E stained eyeball (Figure 4). Few pigment migrations were also noted.…”