Effet du monoxyde d'azote inhalé chez une patiente atteinte d'hypertension intracrânienne

Peillon, D; Jault, V.; Vavaseur, O. Le; Bellanger-Depagne, C.; Jaoua, J.; Combe, Christian

doi:10.1016/s0750-7658(99)90186-7

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Over the past 9 years inhaled nitric oxide (INO) has been used twice in a severely head injured human with ALI/ARDS with success [ 15 , 16 ]. INO, delivered at 10–80 parts per million (ppm), is a very effective pulmonary vasodilator [ 17 ] and improves arterial oxygenation [ 18 - 22 ].…”

Section: Introductionmentioning

confidence: 99%

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Papadimos

Medhkour

Yermal

2009

Scand J Trauma Resusc Emerg Med

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Use of inhaled nitric oxide in humans with traumatic brain injury and acute respiratory distress syndrome has twice previously been reported to be beneficial. Here we report a third case. We propose that INO may decrease the inflammatory response in patients with increased intracranial pressure caused by traumatic brain injury accompanied by acute respiratory distress syndrome thereby contributing to improved outcomes.

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Section: Introductionmentioning

confidence: 99%

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Papadimos

Medhkour

Yermal

2009

Scand J Trauma Resusc Emerg Med

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show abstract

“…However, clinical trials have not shown improved outcomes with its use in ARDS [ 21 - 23 ], including a large phase III study in the United States [ 24 ]. Nonetheless, inhaled nitric oxide (INO) has been successfully used twice in TBI patients with ALI/ARDS [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The beneficial effects of inhaled nitric oxide in patients with severe traumatic brain injury complicated by acute respiratory distress syndrome: a hypothesis

Papadimos

2008

J Trauma Manage Outcomes

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Abstract

Background

The Iraq war has vividly brought the problem of traumatic brain injury to the foreground. The costs of death and morbidity in lost wages, lost taxes, and rehabilitative costs, let alone the emotional costs, are enormous. Military personnel with traumatic brain injury and acute respiratory distress syndrome may represent a substantial problem. Each of these entities, in and of itself, may cause a massive inflammatory response. Both presenting in one patient can precipitate an overwhelming physiological scenario. Inhaled nitric oxide has recently been demonstrated to have anti-inflammatory effects beyond the pulmonary system, in addition to its ability to improve arterial oxygenation. Furthermore, it is virtually without side effects, and can easily be applied to combat casualties or to civilian casualties.

Presentation of hypothesis

Use of inhaled nitric oxide in patients with severe traumatic brain injury and acute respiratory distress syndrome will show a benefit through improved physiological parameters, a decrease in biochemical markers of inflammation and brain injury, thus leading to better outcomes.

Testing of hypothesis

A prospective, randomized, non-blinded clinical trial may be performed in which patients meeting the case definition could be entered into the study. The hypothesis may be confirmed by: (1) demonstrating an improvement in physiologic parameters, intracranial pressure, and brain oxygenation with inhaled nitric oxide use in severely head injured patients, and (2) demonstrating a decrease in biochemical serum markers in such patients; specifically, glial fibrillary acidic protein, inflammatory cytokines, and biomarkers of the hypothalamic-pituitary-adrenal axis, and (3) documentation of outcomes.

Implications of hypothesis

Inhaled nitric oxide therapy in traumatic brain injury patients with acute respiratory distress syndrome could result in increased numbers of lives saved, decreased patient morbidity, decreased hospital costs, decreased insurance carrier and government rehabilitation costs, increased tax revenue secondary to occupational rehabilitation, and families could still have their loved ones among them.

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Mechanical Ventilation in Traumatic Brain Injury

King

Altaweel

2017

Neurotrauma Management for the Severely Injured Polytrauma Patient

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Effet du monoxyde d'azote inhalé chez une patiente atteinte d'hypertension intracrânienne

Cited by 7 publications

References 15 publications

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

The beneficial effects of inhaled nitric oxide in patients with severe traumatic brain injury complicated by acute respiratory distress syndrome: a hypothesis

Mechanical Ventilation in Traumatic Brain Injury

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