Effet protecteur du pédoncule d’ananas au cours de l’intoxication du rat Wistar par le paracétamol

Dougnon, TJ; Kpodékon, T. M.; Ahissou, Hyacinthe; Gbénou, Joachim; Loko, F; Laleye, L.C.

doi:10.4314/ijbcs.v3i4.47153

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…These molecules, some of which have potential antioxidant effects [15], could therefore suppress glutathion depletion and deactivate N-acetyl-pbenzoquinone imine, or inhibit cytochrome P450, as does silymarin. Similar results have been observed with Rhamnus alaternus L., and Ananas comosus, plant substances considered as hepatotropic [16,17].…”

Section: Discussionsupporting

confidence: 88%

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

Mamadou

Coulibaly

Innocent

et al. 2022

BJI

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Aims: The aqueous extract of cashew apple cakes, rich in molecules of pharmacological interest, could be used against many diseases. Thus, the aim of the present work is to evaluate its hepatoprotective activity in rats and mice. Methodology: Two batches of rats weighing between 200 and 300 grams, with five rats per batch, were pretreated for eleven days with the aqueous extract of cashew apple cakes at concentrations ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol at 2 g.Kg-1 bw, for three days. The blood of these rats was collected and submitted to biochemical analyses. Two batches of mice weighing between 20 and 30 grams, with five mice per batch, were pretreated with the same test substance at concentrations also ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol before receiving phenobarbital. Afterwards, their sleep time was evaluated. Results: In rats, paracetamol intoxication materialized by the increase in serum ALT activity ranging from 109±5.19 to 571±20.28 IU.L-1 and that of AST ranging from 144±5.77 to 428±14.19 IU.L-1. Similarly, direct bilirubin increased from 0 to 1.08± 0.58 mg.dl-1. These increases in transaminase activity and bilirubin levels were significantly decreased in rats pretreated with the aqueous extract of cashew apple cake. In mice, the phenobarbital test showed a 29.82 to 38.59% decrease in sleep time in mice pretreated with the aqueous extract of cashew apple cakes. Conclusion: The aqueous extract of cashew apple cakes influencing biochemical parameters such as ALT, AST, bilirubin and sleep time, could therefore be used in the prevention of liver diseases, in traditional medicine.

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Section: Discussionsupporting

confidence: 88%

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

Mamadou

Coulibaly

Innocent

et al. 2022

BJI

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“…Acetaminophen doses above 10 mg/kg bw are extremely dangerous [7] . These intoxications are characterized by nausea, vomiting, anorexia, and abdominal pain [8] . Acetaminophen poisoning is a leading cause of liver failure in countries such as the United States and the United Kingdom [9] .…”

Section: Introductionmentioning

confidence: 99%

Effect of ethanolic extract of Petroselinum crispum (Mill.) Fuss (Apiaceae) strand on acetaminophen-induced hepatotoxicity in wistar rat

Assi,

Beli,

Djetouan

et al. 2024

J Pharmacogn Phytochem

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Petroselinum sativum (Apiaceae) plant is used in traditional medicine practice for the management of many pathologies including renal and liver diseases. Therefore, the current study aims to investigate the hepatoprotective effect of Petroselinum sativum (Apiaceae) against acetaminophen hepatotoxicity in rats. To achieve this aim, thirty adult male albino rats were divided into equal five groups as following, Group I, negative control received 0.9% NaCl orally (Control + NaCl); Groups II, Positive control, received acetaminophen solution at 200 mg/kg bw (Acetam. 200), Groups III, IV, and V received acetaminophen solution at 200 mg/kg bw and vitamin E (250 mg/kg bw), Petroselinum sativum strand ethanolic extract at 200 and 400 mg/kg bw respectively. At the end of experiment (after 7 days), blood samples were collected for biochemical and hematologic analysis. Renal toxicity and oxidative stress were observed in untreated paracetamol-intoxicated rats asResult shown the body-weight gain (p<0.0001) was observed at the 200 mg/kg bw dose of EEBPs. Water consumption (p<0.001) and food consumption (p<0.0001) were improved at 200 and 400 mg/kg bw. Extract of Petroselinum sativum strand resulted in a significant improvement in blood ionograms and renal biomarkers compared with group II, including a significant (p<0.05; p<0.001; p<0.0001)) in creatinine, urea, and total protein. In the liver, there was a significant reduction in hepatic biomarkers and an improvement in hematological parameters.

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“…Pineapple has vitamin B 1 , B 6 and its high content of vitamin C would also contribute to a little (over 30%) of its antioxidant potential [13]. It shows significant effects on hematological and biochemical parameters with Doliprane [14]. Ethanolic extract of Ananas comosus L. leaves has anti-diabetic, anti-dyslipidemic and anti-oxidative activities, which may be developed into a new plant medicine for treatment of diabetes and its complications [15].…”

Section: Introductionmentioning

confidence: 99%

Plant Mediated Synthesis Of Gold Nanoparticles Using Fruit Extracts Of Ananas Comosus (L.) (Pineapple) And Evaluation Of Biological Activities

Basavegowda¹,

Sobczak-Kupiec²,

Malina³

et al. 2013

Adv. Mater. Lett.

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Plant mediated synthesis of metallic nanoparticles is an increasing commercial demand due to the wide applicability in various areas such as electronics, catalysis, chemistry, energy, cosmetics and medicine. In the present investigation, synthesis of gold nanoparticles is done by using fruit extracts of Ananas comosus (L.). Nanoparticles were characterized by using UV visible absorption spectra. Their morphology, elemental composition and crystalline phase were determined by scanning electron microscopy, energy dispersive X-ray spectroscopy and selected area electron diffraction. FT-IR analysis was used to confirm the presence of gold nanoparticles in the extracts. The synthesized gold nanoparticles were generally found to be effective as antimicrobial agents against some important human pathogens like E.coli and Streptobacillus sp. which are affecting and cause diseases like food poisoning and rat-bite fever to human beings respectively.

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Effet protecteur du pédoncule d’ananas au cours de l’intoxication du rat Wistar par le paracétamol

Cited by 3 publications

References 8 publications

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

Effect of ethanolic extract of Petroselinum crispum (Mill.) Fuss (Apiaceae) strand on acetaminophen-induced hepatotoxicity in wistar rat

Plant Mediated Synthesis Of Gold Nanoparticles Using Fruit Extracts Of Ananas Comosus (L.) (Pineapple) And Evaluation Of Biological Activities

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