Effets du cycloheximide sur la mémorisation d'un apprentissage d'evitement chez le rat: Récupération mnésique

Schmaltz, G.; Delerm, B

doi:10.1016/0031-9384(74)90037-7

Cited by 12 publications

(2 citation statements)

References 18 publications

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“…Others have reported that extended training reduced or blocked the amnesic effect of ECS (Geller et .,., ~3-or of protein synthesis hhibition (Barondes, 1970;Flood et al, ,1972Flood et al, , , 1973Schmaltz and Delerm, 1974).…”

Section: ' 'mentioning

confidence: 99%

Protein synthesis dependent gradient of ECS retrograde amnesia

et al. 1977

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The interacting amnesic effectofaprotein synthesis inhibitor, anisomycin, and ECS were studied in active and passive avoidance tasks. By giving on~ to three injections of anisomycin, the duration of inhibition • of protein synthesis was inhibited from 2 to 6 hr at 80% or greater. ECS was administered at various times after training (1 min to 9 hr) to both inhibited and uninhibited mice. The ECS gradient in uninhibited mice was never greater than 30 min. The ECS gradient in anisomycin-treated mice ranged from 3 hr to 8 hr depending on the training strength and the nu~ber of anisomycin injections. The ECS gradient of retrograde amnesia consistently developed at about 1 hr after the recovery of protein synthesis began and this displaced the ECS amnesic gradients by as much as 8-9 hr. The. study also determined that ECS caused only a transient, low percent inhibition of protein synthesis in uninhibited mice. The ECS given to anisomycin-treated mice had only a very slight effect on .inhibition of protein synthesis and did not seem to increase the inhibition enough to account for the amnesia observed. The results are discussed in.terms of the EC~ amnesic gradient being dependent on memory-related protein synthesis that preceeds ECS administration.

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Section: ' 'mentioning

confidence: 99%

Protein synthesis dependent gradient of ECS retrograde amnesia

et al. 1977

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“…The first point has been confirmed by numerous studies (Flood, Bennett, Rosenzweig, & Orme, 1972;Geller, Robustelli, & Jarvik, 1971;Schmaltz & Delerm, 1974;Squire & Barondes, 1972). Flood et al (1972), for example, analyzed with precision the parameters able to affect the degree of amnesia in cycloheximide-treated mice (shock intensity, shock duration, original latency to enter the shock compartment, retention interval), in a one-trial, step-through, passive avoidance task.…”

Section: Cycloheximide and Acetoxycycloheximidementioning

confidence: 60%