Efficacité de la programmation des cycles FIV en antagonistes par les estrogènes

Bruk av GnRH-antagonist ved in vitro-fertilisering

“…Tidligere er det vist at østradioltabletter i lutealfasen før stimuleringsstart kan benyttes for å etablere en homogen vekst av folliklene under stimulering ved bruk av GnRH-antagonist uten at denne forbehandlingen reduserer graviditetsraten (38). Nylig viste en fransk studie at østradioltabletter fra 25. syklusdag også kan benyttes for å programmere stimuleringen uten at sjansen for vellykket graviditet synker (39). Dersom resultatene fra denne studien blir bekreftet av andre, innebaerer det et stort steg fremover i arbeidet med å kunne programmere stimuleringsstart.…”

Can we skip weekends in GnRH antagonist cycles without compromising the final outcome?

“…This effect stops as soon as E 2 administration is discontinued (5). It has already been demonstrated that this approach can achieve similar results to the long protocol (6), and that prolonging the administration of E 2 beyond menses does not affect cycle outcome (7).…”

Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial

“…There are basically three different ways to manage cycle scheduling: [1] a flexible start of the stimulation, because results do not seem to change whether ovarian stimulation is started on day 2 or day 3 of the cycle (2); [2] delaying or advancing hCG administration, because moving it 1 day ahead or postponing 1 extra day does not seem to influence cycle outcome (3); and [3] steroid pretreatment, with either E 2 in the late luteal phase to avoid FSH rise and follicle recruitment (4) or oral contraceptive pills (5), because E 2 will have the afore mentioned effect and P will avoid LH rise.…”