Efficacité du thalidomide dans le traitement de l'histiocytose langerhansienne multisystémique de l'adulte : à propos d'une observation

Alioua, Z.; Hjira, Naoufal; Oumakhir, S.; Frikh, Rachid; Ghfir, M.; Rimani, M.; Sedrati, O.

doi:10.1016/j.revmed.2006.01.022

Cited by 3 publications

(1 citation statement)

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“…Леналидомид также используется в терапии боль ных гистиоцитозами. Описан положительный резуль тат при лечении ингибиторами неоангиогенеза как в наблюдениях за отдельными пациентами [137][138][139], так и за более крупными группами больных. В ис следовании II фазы по применению леналидомида у 11 больных гистиоцитозами (ГКЛ (n = 6), болезнь Эрдгейма-Честера (n = 3), гистиоцитарная саркома (n = 2)) уменьшение жалоб отмечено только у пациен тов с ГКЛ (по 2 пациента достигли полного, частич ного ответа и стабилизации).…”

Section: винбластинunclassified

Langerhans cell histiocytosis in adults: literature review

et al. 2022

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Langerhans cells histiocytosis is a variant of malignant histiocytosis. The course and symptoms vary. patients with localized forms have a better prognosis, because local therapy is effective. patients with multifocal forms of histiocytosis receive systemic drug therapy, which cures some of the patients. This review provides up-to-date data about typical presentation of the organ involvement, diagnosis, course and therapy of various forms of Langerhans cells histiocytosis.

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Section: винбластинunclassified

Langerhans cell histiocytosis in adults: literature review

et al. 2022

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Multisystem Langerhans Cell Histiocytosis

Broekaert

Metzler

Burgdorf

et al. 2007

American Journal of Clinical Dermatology

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A 57-year-old woman presented with a 1-year history of non-healing inguinal and perianal ulcers as well as a 2-year history of polydipsia. The clinical picture and histology suggested Langerhans cell histiocytosis, which was confirmed by immunohistochemistry and electron microscopy. Magnetic resonance imaging of the brain revealed hypothalamic-pituitary axis involvement. Treatment was started with thalidomide and desmopressin. The skin lesions resolved over 2 months. Over the next 24 months of continued therapy, the cerebral involvement remained stable and the skin lesions did not recur.

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