Langerhans cell histiocytosis in adults: literature review

Потапенко, В. Г.; Baykov, V. V.; Zinchenko, A. V.; Потихонова, Н А

doi:10.17650/1818-8346-2022-17-4-16-32

Cited by 3 publications

References 129 publications

(155 reference statements)

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Cladribine chemotherapy of multifocal, multisystemic form of Rosai–Dorfman disease: literature review and case report

Potapenko,

Abramov,

Baykov

et al. 2024

Onkogematologiâ

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Rosai–Dorfman disease is the most frequent variant of non-Langerhans cell histiocytosis. Local forms can be resected or irradiated. If the process involves multiple organs, systemic chemotherapy can cure some patients. This article includes literature review and a case report of a 34-year-old patient with multifocal, multisystemic form of Rosai–Dorfman disease with bone and pleural involvement. The diagnosis was based on histological, immunohistochemical, and molecular studies of tumor tissue. Since November 2021, 6 courses of chemotherapy with cladribine and 8 infusions of zolendronic acid were carried out with achievement of durable remission. The tolerance was acceptable.

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Cladribine chemotherapy of multifocal, multisystemic form of Rosai–Dorfman disease: literature review and case report

Potapenko,

Abramov,

Baykov

et al. 2024

Onkogematologiâ

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Cladribine in the Treatment of Multifocal Multisystem Langerhans Cell Histiocytosis in a Patient with a Poor Prognosis. A Case Report

Потапенко,

Бурлаченко,

Эмиль

et al. 2024

Clinical Oncohematology

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Langerhans cell histiocytosis is a hematologic clonal disease. The treatment of localized histiocytosis includes local methods such as radiotherapy or surgery. In cases of disseminated lesions with multiple system damage, chemotherapy is administered, which provides recovery in some patients. The present paper is a case report of multifocal multisystem Langerhans cell histiocytosis with bone, liver, spleen, abdominal lymph node and pituitary lesions in a 40-year-old patient. The diagnosis was verified by histology and immunohistochemistry of bone biopsy specimens. Polymerase chain reaction revealed no V600E mutation in the BRAF gene in tumor tissue. Persistent antitumor response was achieved after 6 chemotherapy cycles with cladribine monoregimen. This drug was well tolerated by the patient. By the time of this publication, the patient had preserved the persistent response for 38 months.

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Pulmonary Eosinophilias

A. Farajova,

M. Akhundova,

R. Aliyeva

et al. 2024

Eosinophils and Their Role in Human Health and Disease

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Eosinophilia is an increase in the number of eosinophils in the peripheral blood. Among eosinophilias, pulmonary eosinophilias are distinguished, which are manifested by radiological changes and an increased content of eosinophils in the lungs. The basis of pathological changes in pulmonary eosinophilia is the activation of eosinophils. They cause bronchospasm, bronchial hyperreactivity, increased vascular permeability and increased fibrosis processes. In the absence of bronchial hyperreactivity, eosinophils limit the development of allergic reactions, and block and eliminate inflammatory mediators (protective effect). With pathology, such protection is disrupted, and the pool of eosinophils increases and eosinophilia of an inflammatory-destructive nature appears with destruction of the interstitium (cytotoxic effect). The etiology of many pulmonary eosinophilias is unknown; there is a possibility that their occurrence may be influenced by certain medications, parasitic infestations and helminth infections. With many pulmonary eosinophilias, lesions also occur in the skin, bones, blood vessels, hepatobiliary and nervous systems. In the treatment of pulmonary eosinophilia, corticosteroids, interferons, monoclonal antibodies and extracorporeal hemocorrection are used. Symptomatic therapy is prescribed to eliminate the clinical symptoms of the disease and improve the quality of life.

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Langerhans cell histiocytosis in adults: literature review

Cited by 3 publications

References 129 publications

Cladribine chemotherapy of multifocal, multisystemic form of Rosai–Dorfman disease: literature review and case report

Cladribine chemotherapy of multifocal, multisystemic form of Rosai–Dorfman disease: literature review and case report

Cladribine in the Treatment of Multifocal Multisystem Langerhans Cell Histiocytosis in a Patient with a Poor Prognosis. A Case Report

Pulmonary Eosinophilias

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