Efficacy and acceptability of three prolactin-sparing antipsychotics in patient with schizophrenia: a network meta-analysis

Abstract

Background: The present study aimed to systematically evaluate three prolactin-sparing antipsychotics for treating schizophrenia. Methods: We performed a meta-analysis of three prolactin-sparing antipsychotics in patients with schizophrenia. Endpoints of interest were the Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS), Clinical Global Impressions-Severity (CGI-S) and acceptability (all cause discontinuation). Results: A total of 12 trials (2,723 patients) and three drugs (aripiprazole, quetiapine, and ziprasidone) were included. On the PANSS scale, aripiprazole (mean difference [MD]: −6.98, 95% CrI: −12.35, −1.38) was statistically more effective than placebo. When assessed by BPRS, aripiprazole

Delusion of Pregnancy: A Case Report and Literature Review

“…There are multiple drugs such as sertraline, amitriptyline, fluoxetine, alpha-methyldopa, and verapamil which are also known to cause hyperprolactinemia. 33 …”

“…Family therapy and psychoeducation about the condition can ensure the family members cope better with such diagnoses. 5 , 33 …”

“…There are multiple drugs such as sertraline, amitriptyline, fluoxetine, alpha-methyldopa, and verapamil which are also known to cause hyperprolactinemia. 33 DSM-5 defines pseudocyesis as a false belief of being pregnant that is associated with objective signs and reported symptoms of pregnancy, which may include abdominal enlargement, reduced menstrual flow, amenorrhea, subjective sensation of fetal movement, nausea, breast engorgement and secretions, and labor pains at the expected date of delivery. There have been cases reported in the past of patients diagnosed with delusion of pregnancy presenting with physical symptoms such as abdominal distension, sensation of fetal movements, and shortness of breath.…”

“…Family therapy and psychoeducation about the condition can ensure the family members cope better with such diagnoses. 5,33 A huge tally of patients show minimal improvement with the above interventions. Since treatment modalities take different routes, further in-depth exploration and research is necessary to draw a clear distinction between the delusion of pregnancy and pseudocyesis to make sure the patient is better managed.…”

Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review

“…Therefore, prolactin-sparing antipsychotics are recommended for female patients with schizophrenia [ 125 ]. Therefore, considering efficacy and acceptability, quetiapine is usually preferred among prolactin-sparing antipsychotics [ 129 ].…”