Efficacy and bait acceptance of vaccinia vectored rabies glycoprotein vaccine in captive foxes (Vulpes vulpes), raccoon dogs (Nyctereutes procyonoides) and dogs (Canis familiaris)

Cliquet, Florence; Barrat, J; Guiot, Anne-Laure; Cael, N.; Boutrand, S.; Maki, Joanne; Schumacher, C.

doi:10.1016/j.vaccine.2008.06.089

Cited by 32 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This high level of vaccine efficacy compares very favourably with other wildlife vaccines. For example, recent trials of the protection conferred by an orally delivered recombinant poxvirus against artificial plague challenge in prairie dogs have demonstrated an efficacy of only 40-50 per cent (Mencher et al 2004;Rocke et al 2008), while commercial oral rabies vaccine baits have 70-100 per cent efficacy across different species (Cliquet et al 2008). Furthermore, BCG vaccination of wild possums by intranasal and intraconjunctival routes only achieved 69 per cent efficacy of protection against natural Tb infection (Corner et al 2002a).…”

Section: Results (A) Oral Vaccinationmentioning

confidence: 99%

Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums

et al. 2009

View full text Add to dashboard Cite

Bovine tuberculosis (Tb) caused by Mycobacterium bovis has proved refractory to eradication from domestic livestock in countries with wildlife disease reservoirs. Vaccination of wild hosts offers a way of controlling Tb in livestock without wildlife culling. This study was conducted in a Tb-endemic region of New Zealand, where the introduced Australian brushtail possum (Trichosurus vulpecula) is the main wildlife reservoir of Tb. Possums were trapped and vaccinated using a prototype oraldelivery system to deliver the Tb vaccine bacille Calmette -Guerin. Vaccinated and control possums were matched according to age, sex and location, re-trapped bimonthly and assessed for Tb status by palpation and lesion aspiration; the site was depopulated after 2 years and post-mortem examinations were conducted to further identify clinical Tb cases and subclinical infection. Significantly fewer culture-confirmed Tb cases were recorded in vaccinated possums (1/51) compared with control animals (12/71); the transition probability from susceptible to infected was significantly reduced in both males and females by vaccination. Vaccine efficacy was estimated at 95 per cent (87-100%) for females and 96 per cent (82-99%) for males. Hence, this trial demonstrates that orally delivered live bacterial vaccines can significantly protect wildlife against natural disease exposure, indicating that wildlife vaccination, along with existing control methods, could be used to eradicate Tb from domestic animals.

show abstract

Section: Results (A) Oral Vaccinationmentioning

confidence: 99%

Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums

et al. 2009

View full text Add to dashboard Cite

show abstract

“…During the clinical period, the raccoon dogs were agitated and aggressive, and the virus was detected in their salivary glands more frequently than in the salivary glands of foxes (Botvinikin et al, 1983). Other experimental studies were performed for the evaluation of three oral vaccines in raccoon dogs (Schuster et al, 2001;Cliquet et al, 2008a). In the first study, which was conducted on a vaccine strain that is no longer used (Schuster et al, 2001), all raccoon dogs (n = 5) succumbed to rabies, on average, 11.2 days post infection (range: 10-13 days) after challenge with the coyote rabies virus strain.…”

Section: Rabies In Raccoon Dogsmentioning

confidence: 99%

“…Faced with the increase of rabies cases in raccoon dogs at the beginning of the 2000s and the involvement of northern European countries in ORV programmes, specific investigations to assess the efficacy and also the bait acceptance of available oral vaccines for raccoon dogs have been conducted under controlled conditions Cliquet et al, 2008a). These studies demonstrated the satisfactory appetence of Rabigen SAG2 and Raboral V-RG vaccines in experimental animals and their ability to produce specific humoral responses against rabies allowing animals to survive a severe rabies challenge.…”

Section: Efficacymentioning

confidence: 99%

Update on oral vaccination of foxes and raccoon dogs against rabies

2015

EFS2

View full text Add to dashboard Cite

An assessment of a report issued by the European Commission in 2002 is presented about the oral vaccination of foxes against rabies, as well as additional topics such as the rabies aetiology and its occurrence in Europe, the target species for oral vaccination, i.e. foxes and raccoon dogs, the oral vaccines available and their thermostability, rabies surveillance and monitoring, and the recent international guidelines for rabies surveillance are discussed. Foxes are the only known reservoir for rabies in Europe, and raccoon dogs are important transmitters, while other carnivores play a less important epidemiological role. The demographic expansion of raccoon dogs and their movements after hibernation are risk factors for rabies recurrence. The combined densities of foxes and raccoon dogs, which often share the same habitats, could allow rabies epizootics to persist. The epidemiological role and the pathogenesis of rabies in raccoon dogs and other carnivores must still be clarified. Four vaccines are authorised in the EU and their effectiveness is proven to successfully contribute to rabies elimination. Experimental and field evidence shows that climatic and weather conditions may impact on bait casings and vaccine stability. Data on the stability of vaccine baits under different field conditions should be provided. It is recommended that bait should keep its integrity at the release point. Because of bait stability issues, the season most appropriate for implementing oral rabies vaccination or a heat-stable vaccine should be considered. Rabies surveillance and monitoring of vaccination, based on assessment of bait uptake and seroconversion in host species, are important tools for the evaluation and adjustment of vaccination campaigns, although alternatives to tetracyclines as biomarkers should be developed. Oral immunisation by vaccine baits has proven to be successful in eliminating terrestrial wildlife rabies, but long-term strategy, temporal continuity of vaccination and cross-border cooperation are needed and recommended. Acknowledgements:The Panel wishes to thank Florence Cliquet, Paola De Benedictis, Kaarina Kauhala, Edvīns Oļševskis, Liisa Sihvonen (Chair) and Marcin Smreczak for the preparatory work on this scientific output, the hearing expert Thomas Müller and EFSA staff members Alessandro Broglia and Marianne Carson for the support provided to this scientific output. Suggested citation: EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare), 2015. Scientific opinion -Update on oral vaccination of foxes and raccoon dogs against rabies.

show abstract

“…These results were used in the development of the RABORAL V RG rabies vaccine, which is currently widely applied for the perioral vaccination of foxes and raccoon dogs [25]. Although this vaccine was ineffi cient in other animal species, orthopoxviruses are considered as promising candidates for the construc tion of rabies vaccines: they are stable in the environ ment and relatively easy to handle under laboratory conditions; their large genome can incorporate long fragments of foreign DNA and, finally, they activate both types of immune response when used as vaccines [26].…”

Section: Rabies Vaccines Based On Viral Vectorsmentioning

confidence: 99%

Rabies vaccines: Current status and prospects for development

et al. 2015

View full text Add to dashboard Cite

Rabies is an infectious disease among humans and animals that remains incurable, despite its longstanding research history. The only way to prevent the disease is prompt treatment, including vaccination as an obligatory component and administration of antirabies immunoglobulin as a supplement. Since the first antirabies vaccination performed in the 19th century, a large number of different rabies vaccines have been developed. Progress in molecular biology and biotechnology enabled the development of effective and safe technologies of vaccine production. Currently, new generation vaccines are being developed based on recombinant rabies virus strains or on the production of an individual recombinant rabies antigen-glyco protein (G protein), either as a component of nonpathogenic viruses, or in plants, or in the form of DNA vac cines. In this review, the main modern trends in the development of rabies vaccines have been discussed.

show abstract

Efficacy and bait acceptance of vaccinia vectored rabies glycoprotein vaccine in captive foxes (Vulpes vulpes), raccoon dogs (Nyctereutes procyonoides) and dogs (Canis familiaris)

Cited by 32 publications

References 24 publications

Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums

Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums

Update on oral vaccination of foxes and raccoon dogs against rabies

Rabies vaccines: Current status and prospects for development

Contact Info

Product

Resources

About