2021
DOI: 10.1177/11206721211014381
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Efficacy and safety data for the Ab interno XEN45 gel stent implant at 3 Years: A retrospective analysis

Abstract: Purpose: To report efficacy and safety measures of the XEN45 gel stent at 36 months in the UK National Health Service setting. Methods: Retrospective non-comparative audit of the records of patients who underwent XEN45 implantation between June 2015 and May 2017 was performed. Main outcome measures were intraocular pressure and number of antihypertensive medications used. Failure was defined as need for further surgery or stent removal. Success was defined as a 20% decrease in intraocular pressure without the … Show more

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Cited by 20 publications
(48 citation statements)
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“…One interesting observation is that in the Basel study, the only significant IOP difference between the two groups was observed at month 1, whereas practically all the bleb needlings (10) in the XEN45 group took place after month 1, based on this IOP increase. This would be 3 – 4 months sooner than published findings might suggest 19 , 20 , with the overall number of needlings in XEN45 patients (10/30) corresponding to literature values, between 25 – 40% 21 , 22 . Furthermore, in the latter referenced study, early needling reduced the necessity for subsequent needlings, which could also be interpreted as the lower the threshold for the first needling and the sooner it takes place, the better.…”
Section: Discussionsupporting
confidence: 51%
“…One interesting observation is that in the Basel study, the only significant IOP difference between the two groups was observed at month 1, whereas practically all the bleb needlings (10) in the XEN45 group took place after month 1, based on this IOP increase. This would be 3 – 4 months sooner than published findings might suggest 19 , 20 , with the overall number of needlings in XEN45 patients (10/30) corresponding to literature values, between 25 – 40% 21 , 22 . Furthermore, in the latter referenced study, early needling reduced the necessity for subsequent needlings, which could also be interpreted as the lower the threshold for the first needling and the sooner it takes place, the better.…”
Section: Discussionsupporting
confidence: 51%
“…We found that a failed trabectome surgery does not affect the outcomes, including postoperative IOP, postoperative medication score, side effects, revision rate, repeat surgery rate, and success rate, of a subsequent XEN45 gel stent implantation. Our findings, which were consistent with those of previous studies, provided further evidence for the efficacy of XEN gel stent implantation in reducing both IOP and medication scores while retaining a favorable safety profile [10][11][12][13][14][15][16].…”
Section: Discussionsupporting
confidence: 92%
“…The implant has a small lumen, which assures a moderate drainage of the aqueous humor into the subconjunctival space with minimal side effects, such as hypotony. Several researchers have reported on their favorable safety profile, along with the promising IOP-lowering potential [10][11][12][13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…The other two studies showed similar results: males had more failures than females [95% CI for effect: 4.3-56%, p = 0.023 (26); OR: 3.57, p = 0.030 (17)]. However, Gabbay et al (64) reported that female was found to be 2.3 times (95% CI 1.1-4.9, p = 0.02) more likely to fail. Conflicting results have also been reported by Mansouri et al (29) and Sng et al (20).…”
Section: Risk Factors For Failurementioning
confidence: 68%
“…The severity of glaucoma defined by MD was a suspicious risk factor (Cox hazard ratio = 1.04), but it was not statistically significant (p = 0.14) (29). Schlenker et al (72) and Gabbay et al (64) demonstrated that white ethnicity was associated with a lower risk of failure (adjusted HR, 0.49; 95% CI, 0.25-0.96; 95% CI 1.9-12.4, p = 0.001), whereas diabetes was associated with an increased risk of failure (adjusted HR, 4.21; 95% CI, 2. 10-8.45).…”
Section: Risk Factors For Failurementioning
confidence: 99%