Efficacy and safety of 308‐nm excimer lamp in the treatment of scalp psoriasis: a retrospective study

Rattanakaemakorn, Ploysyne; Phusuphitchayanan, Phanitchanat; Pakornphadungsit, Kallapan; Thadanipon, Kunlawat; Suchonwanit, Poonkiat

doi:10.1111/phpp.12448

Cited by 7 publications

(9 citation statements)

References 30 publications

(41 reference statements)

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“…Several studies have shown both the 308-nm excimer laser and light to be useful tools for the treatment of scalp plaques [ 26 – 28 ]. A 2004 study evaluated the 308 nm excimer laser for the treatment of patients who had refractory scalp psoriasis unresponsive to class I steroids and medicated shampoos [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Treatment with the excimer lamp was associated with a significant improvement in itch and PSSI. The most common adverse events reported were pain and erythema, but all adverse events resolved within 7 days [ 26 ]. While early results appear promising, device availability may be limited and further research is needed.…”

Section: Resultsmentioning

confidence: 99%

“…Improvement in PSSI was present as early as week 4 [28]. Furthermore, a novel nonlaser monochromatic excimer 308 nm light, which provides a more powerful and larger irradiation area, was evaluated for the treatment of scalp psoriasis [26]. Results from the retrospective study revealed that 11 out of 20 patients achieved more than 50% improvement after a total of ten sessions.…”

Section: Phototherapymentioning

confidence: 99%

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Scalp Psoriasis: A Literature Review of Effective Therapies and Updated Recommendations for Practical Management

Mosca

Hong

Hadeler

et al. 2021

Dermatol Ther (Heidelb)

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The scalp is one of the most commonly affected regions in psoriasis. However, scalp psoriasis can be difficult to treat because of challenges in the delivery of therapy. Effective therapeutic regimens for scalp psoriasis are essential to improving the quality of life of patients. Recent data on topical therapies, phototherapy, systemic agents, and complementary therapy have demonstrated that it is possible to achieve and maintain significant improvement in scalp psoriasis. In this review, efficacy data for these modalities and an algorithm for the practical management of scalp psoriasis are presented.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Phototherapymentioning

confidence: 99%

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Scalp Psoriasis: A Literature Review of Effective Therapies and Updated Recommendations for Practical Management

Mosca

Hong

Hadeler

et al. 2021

Dermatol Ther (Heidelb)

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“…Earlier studies found that 308nm excimer laser was able to achieve exceptional results in the previously recalcitrant area of the scalp (5)(6)(7). A previous study using a 308-nm excimer lamp, a non-laser device, also demonstrated a similar favorable result in the treatment of scalp psoriasis with minimal and transient side effects (8). Comparing to the excimer laser, the excimer lamp has the superior advantage of being able to give uniform irradiation of 50 times wider area in a single exposure at a lower cost (9).…”

Section: Introductionmentioning

confidence: 87%

308-nm Excimer Lamp vs. Combination of 308-nm Excimer Lamp and 10% Liquor Carbonis Detergens in Patients With Scalp Psoriasis: A Randomized, Single-Blinded, Controlled Trial

et al. 2021

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Background: Scalp psoriasis is usually refractory to treatment. Excimer devices have been proved to be a promising therapeutic option in psoriasis. Greater efficacy of phototherapy can be achieved by concurrent use of coal tar derivatives.Objective: We aimed to compare efficacy and safety between 308-nm excimer lamp monotherapy and a combination of 308-nm excimer lamp and 10% liquor carbonis detergens in the treatment of scalp psoriasis.Methods: In this randomized, evaluator-blinded, prospective, comparative study, 30 patients with scalp psoriasis received either 308-nm excimer lamp monotherapy or a combination of 308-nm excimer lamp and 10% liquor carbonis detergens twice per week until complete remission of the scalp or for a total of 30 sessions. Efficacy was evaluated by the improvement of Psoriasis Scalp Severity Index (PSSI) score, itch score, and Scalpdex score.Results: Both treatments induced significant improvement in PSSI score with greater reduction observed in the combination group. At 30th visit, a 75% reduction in PSSI (PSSI75) was attained by 4 (28.6%) and 9 (69.2%) patients treated with monotherapy and combination therapy, respectively (P < 0.05).Conclusions: Excimer lamp is well-tolerated in patients with scalp psoriasis and liquor carbonis detergens can be used as a combination therapy to improve the efficacy of excimer lamp.

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“…With 308-nm excimer light, the energy delivered to the irradiated area of skin is 5-10 times higher than that delivered with NB-UVB, and the skin lesions can also reduce the risk of skin photoaging and carcinogenesis while receiving high-energy treatment (3). Some scholars have concluded through clinical comparative studies that while there is no statistical difference in efficacy or safety between 308-nm excimer light and 308-nm excimer laser, 308-nm excimer light offers a bettermore effectiveness treatment than 308-nm excimer laser at a lower cost (4,5).…”

Section: Introductionmentioning

confidence: 99%

The effect of Xiaobi decoction on minimal erythema dose of irradiation with 308 nm excimer lamp in guinea pigs

Wen

Wang³

et al. 2020

Ann Palliat Med

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Background: Psoriasis is a chronic autoimmune-mediated inflammatory skin disease. The main clinical manifestation of this complex condition is scaly erythema. Excimer 308-nm light can be used to selectively and safely treat skin lesions. In clinical practice, the combination of Xiaobi decoction combined with 308nm excimer light therapy has been found to have a beneficial effect on advanced psoriasis vulgaris. However, the effect of Xiaobi decoction on light sensitivity in psoriasis patients has not been explored. Therefore, this study aimed to observe the effect of Xiaobi decoction on the minimal erythema dose (MED) value in guinea pigs.Methods: Eighty guinea pigs were divided into a Xiaobi decoction group and a control group according to the serial number: guinea pigs with odd numbers were assigned into the Xiaobi decoction group, and those with even numbers were assigned into the control group. The Xiaobi decoction group was administrated Xiaobi decoction by gastric lavage, while the control group was given distilled water by gastric lavage. The back skin of the guinea pigs in the two groups was irradiated with a 308-nm excimer lamp before gavaging, and after 10, 20, and 30 days of gavaging. The MED values 24 hours after irradiation were recorded. Results:The average MED in the Xiaobi decoction group was (800±126.5) mJ/cm 2 , compared with (780±107.7) mJ/cm 2 in the control group, and the difference was not significant (P>0.05). After 10 days, 20 days, and 30 days of gavaging, the MED values of the guinea pigs in the Xiaobi decoction group were significantly lower than those of the control group (P<0.05). Blood tests showed that the levels of vascular endothelial growth factor (164.5±25.7 vs. 145.3±27.4, P=0.002) and interleukin-23 (1.8±0.7 vs. 1.5±0.5, P=0.030) were significantly lower in the Xiaobi decoction group than in the control group. Conclusions:Xiaobi decoction can reduce the MED value of guinea pigs, and increase the sensitivity of skin lesions to 308-nm excimer light and the amount of light absorbed by skin lesions. These results may represent the mechanisms of action of Xiaobi decoction in the treatment of psoriasis.

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Efficacy and safety of 308‐nm excimer lamp in the treatment of scalp psoriasis: a retrospective study

Cited by 7 publications

References 30 publications

Scalp Psoriasis: A Literature Review of Effective Therapies and Updated Recommendations for Practical Management

Scalp Psoriasis: A Literature Review of Effective Therapies and Updated Recommendations for Practical Management

308-nm Excimer Lamp vs. Combination of 308-nm Excimer Lamp and 10% Liquor Carbonis Detergens in Patients With Scalp Psoriasis: A Randomized, Single-Blinded, Controlled Trial

The effect of Xiaobi decoction on minimal erythema dose of irradiation with 308 nm excimer lamp in guinea pigs

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