Efficacy and safety of a new intradermal PCV2 vaccine in pigs

Efficacy of Needle-Less Intradermal Vaccination against Porcine Epidemic Diarrhea Virus

“…An attenuated PRRS vaccine administered via the ID route can efficiently induce a protective immune response in pigs subsequently exposed to a genetically diverse PRRSV isolate [ 9 ]. The safety and efficacy of a new intradermal one dose vaccine containing the PCV2 antigen (Porcilis ® PCV ID) was evaluated and showed that the vaccine was safe and provided protection until at least 23 weeks post-vaccination, which is a typical slaughter age [ 4 ].…”

“…Pathogens 2021, 10, 1115 2 of 12 prevents accidental transmission of pathogens through reuse of needles; it also reduces the risk of broken needles being left in the muscle [4]. Compared with IM injection, vaccination into the dermis has the advantage of accessibility to dendritic cells at the site of administration, along with close proximity to skin-draining lymph nodes; this results in a more rapid and direct response to the antigen in the vaccine.…”

“…The main vaccination route is intramuscular (IM); the secondary route is oral (for the live attenuated vaccine). Due to needle-free administration, an intradermal (ID) vaccine is more animal-friendly and prevents accidental transmission of pathogens through reuse of needles; it also reduces the risk of broken needles being left in the muscle [4]. Compared with IM injection, vaccination into the Pathogens 2021, 10, 1115 2 of 12 dermis has the advantage of accessibility to dendritic cells at the site of administration, along with close proximity to skin-draining lymph nodes; this results in a more rapid and direct response to the antigen in the vaccine.…”

Efficacy of Simultaneous Intradermal Vaccination of Swine against Porcine Circovirus 2, Porcine Reproductive and Respiratory Syndrome Virus, Mycoplasma hyopneumoniae and Lawsonia intracellularis

“…In recent years, a number of swine vaccines for intradermal administration have been developed [ 21 , 22 , 23 , 24 ]. Porcilis PRRS ID is a live-attenuated PRRSV1 vaccine, which is reconstituted from freeze-dried in the adjuvant Diluvac Forte before application.…”

“…Porcilis PCV ID and Porcilis M Hyo ID ONCE have been shown to be safe and efficacious when used concurrently, where the vaccines are given at the same time but at different sites on the animal [ 22 ]. The efficacy of Porcilis PCV ID in associated mixed use with Porcilis Lawsonia ID has also been reported [ 21 ].…”