Efficacy and Safety of a Fixed Combination of Tramadol and Paracetamol (Acetaminophen) as Pain Therapy Within Palliative Medicine

Husić, Samir; Izic, Senad; Matic, Srecko; Sukalo, Aziz

doi:10.5455/msm.2014.27.42-47

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…However, it can cause many side effects, such as diarrhea, 55 nausea or vomiting. 56 Ibuprofen and naproxen belong to NSAIDs and are also main medicine for chronic cervical pain therapy, 11,12 but ibuprofen usage is related to the incidence of fever, vomiting, diarrhea, rhinitis, rash and otitis, 57 and naproxen usage often results in diarrhea with lower abdominal pain. 58 Just because of these unwanted adverse effects, we are very hesitant to create such a control group.…”

Section: Discussionmentioning

confidence: 99%

The effects of black soybean (Glycine max var.) on chronic cervical pain of sedentary office workers in a northern Chinese population

Tian

Wang

2015

Food Funct.

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Chronic cervical pain is a common symptom of sedentary office workers. Black soybean (Glycine max var.) has rich necessary nutrients for the therapy of chronic pain. Thus, it may ease chronic cervical pain. To prove our claim, 260 sedentary office workers with chronic pain were recruited and they consumed the defined diets at breakfast, lunch, and dinner with 1 g, 5 g and 10 g (3 g, 15 g, 30 g daily) cooked black soybean for 24 weeks. Visual analog scale (VAS), neck disability index (NDI) pain scores and short-form 36 (SF-36) health survey questionnaires were applied in the study. The levels of N-methyl-D-aspartate receptors (NMDAR) were measured. The VAS and NDI pain scores reduced and SF-36 scores increased in a 15 or 30 g black soybean daily group compared with a 3 g black soybean daily group after a 24-week therapy (P < 0.05). The 30 g black soybean daily group was better than the 15 g black soybean daily group in relieving chronic cervical pain of sedentary office workers (p < 0.05). The levels of NMDAR were lower in the 15 or 30 black soybean daily group than those in the 3 g black soybean daily group (P < 0.05). Black soybean can ameliorate chronic cervical pain by down-regulating the levels of NMDAR.

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Section: Discussionmentioning

confidence: 99%

The effects of black soybean (Glycine max var.) on chronic cervical pain of sedentary office workers in a northern Chinese population

Tian

Wang

2015

Food Funct.

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“…Cancer pain is a common yet burdensome part of life for cancer patients, particularly in the advanced stages of the disease [1][2][3]. More than one-third of cancer patients have pain at the time of diagnosis [4]. This prevalence increases with advancing stages, to as much as 90% in patients with bone metastases [5].…”

Section: Introductionmentioning

confidence: 99%

“…At some stage in their cancer journey, most patients will experience acute pain. As many as 40-50% of patients with cancer pain experience moderate-to-severe acute pain [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Management of Acute Cancer Pain in Asia: An Expert Opinion on the Role of Tramadol/Dexketoprofen Fixed-Dose Combination

Tuan¹,

Wang²,

Leon³

et al. 2023

Cureus

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Most patients experience acute cancer pain at some stage throughout their cancer journey. When inadequately managed, cancer pain has devastating consequences for the patient's quality of life.The suboptimal management of cancer pain in Asia is mainly driven by over-regulation and limited access to opioids. Concerns about adverse events and addiction have resulted in a negative perception of this group of drugs among physicians, as well as patients. There is a need to optimize the management of cancer pain across the region, through the provision of an alternative treatment option that is simple to prescribe, convenient to administer and well tolerated by patients, which will increase patients' compliance and good results.As recommended in many international guidelines, starting by the WHO analgesic ladder, cancer pain can be effectively managed with multimodal analgesia. Fixed-dose combinations (FDCs), in which two or more analgesic agents act synergistically to deliver a broad spectrum of pain relief, represent an effective and convenient option for delivering multimodal analgesia to patients with cancer pain. This is extremely well accepted by patients for several reasons. Any multimodal pharmacological approach to pain management should be based on the potentiality to block pain at different levels and to reduce the dosages of single analgesics, reducing their side effects. Hence, the use of NSAIDs, combined with other analgesics, is the general basis of multimodal pain management. If NSAIDs are combined with tramadol, a weak opioid that has per se a multimodal analgesic efficacy, it may be ideal. The tramadol/dexketoprofen FDC combines the centrally acting weak opioid with a peripherally acting NSAID to deliver rapid-onset, long-lasting analgesia, which has been proven efficacious and safe in the management of moderate-to-severe acute pain in the postoperative setting. This expert opinion explores the role of tramadol/dexketoprofen FDC in the management of patients with moderate-to-severe acute cancer pain. It is essentially based on the incredibly high amount of existing data on the use of the drug, and on the long-lasting experience of the experts in pain management of cancer patients participating in the advisory panel.

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Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

Dai

Xu³

et al. 2021

European Journal of Pharmacology

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Efficacy and Safety of a Fixed Combination of Tramadol and Paracetamol (Acetaminophen) as Pain Therapy Within Palliative Medicine

Cited by 3 publications

References 18 publications

The effects of black soybean (Glycine max var.) on chronic cervical pain of sedentary office workers in a northern Chinese population

The effects of black soybean (Glycine max var.) on chronic cervical pain of sedentary office workers in a northern Chinese population

Management of Acute Cancer Pain in Asia: An Expert Opinion on the Role of Tramadol/Dexketoprofen Fixed-Dose Combination

Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

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