Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

Aladren, Sonia; Garre, Aurora; Valderas-Martínez, Palmira; Piquero-Casals, Jaime; Granger, Corinne

doi:10.3390/cosmetics6010015

Cited by 15 publications

(8 citation statements)

References 26 publications

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“…It is probably the most complex hyperpigmentary disorder with a poorly understood etiology. Although Q-Switched 1064 nm laser seems to have better results than other types of lasers, results remain controversial [ 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nisticò

Cannarozzo

Provenzano³

et al. 2021

Clinics and Practice

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(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.

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Section: Discussionmentioning

confidence: 99%

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nisticò

Cannarozzo

Provenzano³

et al. 2021

Clinics and Practice

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“…Although the 1064 wavelength usually gives better results to dermal melanosis, the outcome remains controversial in melasma, probably related to its poorly understood etiology [21][22][23]. Acquired hyperpigmentations seem to reach better cosmetic outcomes than their congenital ones [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Q-Switched 1064/532 nm Laser with Picosecond Pulse to Treat Benign Hyperpigmentations: A Single-Center Retrospective Study

et al. 2021

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(1) Benign melanoses are a frequent issue in aesthetic dermatology. Solar lentigo, ephelides, café au lait spots, and other melanoses represent a cosmetic issue for a growing number of subjects. The Q-switched 1064/532-nanometer (nm) laser may be considered the gold standard for management of these aesthetic issues. A new generation of Q-switched lasers, capable of concentrating the energy pulse in the spectrum of hundreds of picoseconds, is emerging, promising better results than previous ones. In this paper, we report the use of a Q-switched laser with a picosecond pulse to manage hypermelanoses. (2) Methods: 36 patients seeking melanosis removal were retrospectively enrolled at Magna Graecia University of Catanzaro. Treatment parameters, although variable, were the following: 1064 nm with a pulse duration of 450 picoseconds (ps) for dermic lesions and 532 nm with 370 ps for epidermal lesions. Up to four treatments, with a minimum interval between laser treatments of 30 days, were performed. After the last session, patients’ satisfaction was assessed at a three-month follow up with a Visual Analogue Scale (VAS). Two blinded dermatologists measured the aesthetic outcome using a five-point scale comparing pictures before laser sessions and during follow-up. (3) Results: 36 patients were enrolled; 23 were females (63.9%) and 13 males (36.1%). The mean reported age was 49.2 ± 18.9 years. All participants were assessed with a complete/almost complete melanosis removal at the dermatological evaluation, with a mean VAS score of 9.39 ± 0.90. (4) Conclusions: The Q-switched 1064/532 nm laser may be considered the main weapon in treating benign hypermelanosis. The picosecond pulse seems to guarantee better results than other devices. However, a clinical trial comparing Q-switched nanosecond pulse with picosecond pulse is necessary to confirm this study’s findings.

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“…For example, mediators such as endothelin-1 (ED1), secreted by vascular endothelial cells and keratinocytes, seem to be related to increased tyrosinase activity and the resulting UVB-induced skin pigmentation. [6][7][8][9] In this study, we evaluated the depigmenting action of PBE by quantifying melanin synthesis, tyrosinase activity, endothelin-1 (ED1), and peroxisome proliferator-activated receptors (PPAR) α, δ, and γ production under the action of UVA/UVB, IR-A, VL, and the association of all these forms of radiation (ASS).…”

Section: Introductionmentioning

confidence: 99%

“…For the last decades, studies have been made to clarify the biomolecular pathways involved in the hyperpigmentation process. For example, mediators such as endothelin‐1 (ED1), secreted by vascular endothelial cells and keratinocytes, seem to be related to increased tyrosinase activity and the resulting UVB‐induced skin pigmentation 6‐9 …”

Section: Introductionmentioning

confidence: 99%

Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin‐1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation

Ayres

Silva

Eberlin³

et al. 2021

J of Cosmetic Dermatology

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Background: French maritime pine bark (Pinus pinaster) extract (PBE), the registered trade name of which is Pycnogenol ® , has been studied for its depigmenting action due to its antioxidant, anti-inflammatory, and anti-melanogenic activity. However, the mechanisms through which PBE are still not fully clear.Objective: Evaluate the impact of PBE on four in vitro parameters closely associated with cutaneous pigmentation, including melanin synthesis, tyrosinase activity, endothelin-1 (ED1), and production of peroxisome proliferator-activated receptor α, δ, and γ (PPAR α, δ, and γ), by studying the modulation of action of ultraviolet radiation A (UVA)/ultraviolet radiation B (UVB), infrared-A (IR-A), visible light (VL), and association of UVA/UVB, IR-A, and VL (ASS).Methods: Human melanocytes were incubated in a dry extract solution of PBE, exposed to UVA/UVB, IR-A, VL, and ASS for subsequent quantification of melanin, ED1, and PPAR α, δ, and γ. The effects of PBE on inhibition of tyrosinase activity were also performed by monophenolase activity assay.Results: UVA/UVB, IR-A, VL, and ASS radiation caused significant increases in the synthesis of melanin, ED1, and PPAR α, δ, and γ when compared to baseline control.However, PBE significantly reduced the production of melanin, ED1, and PPAR α, δ, and γ, as well as reducing about 66.5% of the tyrosinase activity.Conclusions: PBE reduces in vitro melanin production by downregulating tyrosinase and reducing pigmentation-related mediators, such as ED1 and PPAR α, δ, and γ, therefore contributing to the inhibition of pathways associated with skin hyperpigmentation.

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Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

Cited by 15 publications

References 26 publications

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Q-Switched 1064/532 nm Laser with Picosecond Pulse to Treat Benign Hyperpigmentations: A Single-Center Retrospective Study

Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin‐1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation

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