Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

Reimund, Jean‐Marie; Rahmi, Gabriel; Escalin, G.; Pinna, Guillaume; Finck, G.; Muller, Christian D.; Duclos, Bernard; Baumann, René

doi:10.1111/j.1365-2036.2005.02354.x

Cited by 75 publications

(55 citation statements)

References 36 publications

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“…Another approach to hybrid lipids has been to mix a dominant amount of olive oil (80%) with lowered amounts of soybean oil (20%) [47][48][49]. This has been shown to be a safe and effective way to deliver fat.…”

Section: What Is the Evidence That A Combination Of Lipid Types Resulmentioning

confidence: 98%

Parenteral nutrition–associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review

Rangel¹,

Calkins

Cowles

et al. 2012

Journal of Pediatric Surgery

126

114

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Section: What Is the Evidence That A Combination Of Lipid Types Resulmentioning

confidence: 98%

Parenteral nutrition–associated cholestasis: an American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review

Rangel¹,

Calkins

Cowles

et al. 2012

Journal of Pediatric Surgery

126

114

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“…Indeed, recent evidence suggests that intracellular accumulation of saturated fatty acids induces ER stress and leads to lipotoxicity in the liver [11,13,14,15]. Palmitic acid (C16:0) is one of the saturated fatty acids and its concentration in commonly used lipid emulsions Intralipide is 11.0 mol% [16]. With this in mind, we hypothesize that ER stress may also be induced by lipid emulsions and associated with PNALD.…”

Section: Introductionmentioning

confidence: 99%

Palmitate Induces TRB3 Expression and Promotes Apoptosis in Human Liver Cells

Yan

Wang

Xiao

et al. 2014

Cell Physiol Biochem

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Background/Aims: Parenteral nutrition-associated liver disease (PNALD) is a major complication for patients who require long-term parenteral nutrition. Treatment options for PNALD are limited and its pathogenesis is poorly understood. Tribbles homolog 3 (TRB3) is a pseudokinase that modulates many signal transduction cascades and may be involved in the pathogenesis of PNALD. The aim of this study was to examine the role of TRB3 in palmitate-induced endoplasmic reticulum (ER) stress, in the human liver cell line L02. Methods: L02 cells were treated with palmitate, and its effect on cell viability, mitochondrial membrane potential, apoptosis and TRB3 expression were assessed. The role of TRB3 was also studied using transient overexpression of TRB3 in L02 cells, as well as its interaction with Akt signaling. Results: We found that palmitate induced ER stress and apoptosis in L02 cells. Palmitate-associated ER stress was accompanied by a significant induction of TRB3 expression at the mRNA and protein level. Overexpression of TRB3 potentiated the deleterious effects of palmitate, which was associated with decreased levels of phospho-Akt. Conclusions: TRB3 is an important mediator of palmitate-induced apoptosis in human liver cells, suggesting that it may also be involved in the molecular mechanism underlying PNALD.

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“…This results in MUFA and PUFA concentrations of 65% and 20% respectively, with an n-6 to n-3 PUFA high ratio of 9:1, but a very low linoleic acid content. The small clinical tests available indicate safety and good tolerance but no immunomodulating effects [26].…”

Section: Oo: Olive-oil Based Lipid Emulsionsmentioning

confidence: 99%