Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome

Mosaffa-Jahromi, Maryam; Lankarani, Kamran Bagheri; Pasalar, Mehdi; Afsharypuor, Suleiman; Tamaddon, Ali Mohammad

doi:10.1016/j.jep.2016.10.083

Cited by 47 publications

(43 citation statements)

References 46 publications

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“…Studies have affirmed that cinnamon (C. verum) has many benefits, including management of blood glucose levels (Hlebowicz et al, 2007), weight loss (Whitfield et al, 2016), detoxification (Xing et al, 2014), and increasing the amount of milk (Guler and Seker, 2009;Dog, 2009), but it should not be combined with fenugreek (T. arabica) because it can lower blood pressure (Talpur et al, 2005). Anise (P. anisum) can be used to increase the amount of milk (Kent et al, 2012), for constipation and irritable bowel syndrome (Mercadante et al, 2011;Mosaffa-Jahromi et al, 2016), and to induce sleep (Marinov and Valcheva-Kuzmanova, 2015). Peppermint (M. piperita) is mainly used to induce calming and relaxing effects (Cook and Lynch, 2008).…”

Section: Discussionmentioning

confidence: 99%

Public Knowledge, Attitude, and Practice on Herbal Remedies Used During Pregnancy and Lactation in West Bank Palestine

Eid

Jaradat

2020

Front. Pharmacol.

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The use of herbal products by pregnant and lactating mothers without awareness of their harmful effects may expose both mother and fetus or infant to great dangers, such as abortion, premature delivery, uterine bleeding, and physical and mental retardation of the fetus. Thus, the aim of this study was to investigate the extent to which herbal product treatment is used and the reason for which such products are used and to ensure that these reasons are correct. An ethnopharmacological survey (cross-sectional observational design study) using a pre-piloted questionnaire was undertaken on herbal products used by pregnant and lactating women in the West Bank area of Palestine. A questionnaire was distributed to 350 pregnant and lactating women. The informed consent forms, ethics, and aims of the present study were reviewed and approved by the Institutional Review Board (IRB) at An-Najah National University. To identify the most important species used, the use value (UV) index was employed, while the SPSS program was used to analyze the data. Collected data revealed that 13 medicinal plants are utilized, while 12 plants are not used during pregnancy. Moreover, 15 plants are utilized and 9 plants are not used during lactation for treating and dealing with various problems. The most commonly used plants belonged to 14 families, including Lamiaceae, Apiaceae, Leguminosae, and Rubiaceae. The plants most used during pregnancy were sage (Salvia fruticosa), anise (Pimpinella anisum), and peppermint (Mentha × piperita). Castor (Ricinus communis) oil, ginger (Zingiber officinale), saffron (Crocus sativus), and senna (Senna alexandrina) mostly were not used by pregnant women. Moreover, cinnamon (Cinnamomum verum), anise (P. anisum), peppermint (M. piperita), and sage (S. fruticosa) were mostly used during lactation. Castor (R. communis) oil, ginger (Z. officinale), garlic (Allium sativum), and aloe (Aloe vera) mostly were not used during lactation. This study is of great importance in order to decrease the possibility of endangering the lives of fetuses and infants. A combined effort among researchers, scientists, lactating women, and pregnant women may help in changing wrong uses and thoughts about medicinal plants and help to improve the overall health of both mother and fetus.

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Section: Discussionmentioning

confidence: 99%

Public Knowledge, Attitude, and Practice on Herbal Remedies Used During Pregnancy and Lactation in West Bank Palestine

Eid

Jaradat

2020

Front. Pharmacol.

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“…We identified two additional studies of peppermint oil since the previous monograph (172,173). There were therefore seven RCTs (172)(173)(174)(175)(176)(177)(178), involving 634 patients. In one of these, there were no dichotomous data reported, but we contacted the authors and successfully obtained these (172).…”

Section: Quality Of Evidence: Lowmentioning

confidence: 99%

“…There were too few studies to assess for any evidence of funnel plot asymmetry. Data on overall adverse events were provided by six trials (172,173,(175)(176)(177)(178). When data were pooled, the incidence of adverse events was not significantly higher among those taking peppermint oil, compared with placebo (RR = 1.90; 95% CI 0.81 to 4.48).…”

Section: Quality Of Evidence: Lowmentioning

confidence: 99%

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Ford

Martin

Chey

et al. 2018

American Journal of Gastroenterology

286

396

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IntroductionIrritable bowel syndrome (IBS) is the most prevalent of the functional gastrointestinal disorders (FGIDs). Current estimates are that IBS affects up to 10-12% of adults in North America (1,2). Although it can affect all individuals regardless of age, creed, or gender, IBS is more common among women and is most commonly diagnosed in younger individuals (< age 50) (2, 3). IBS is characterized by recurrent abdominal pain and altered bowel habits; bloating and distention frequently coexist. The diagnosis of IBS is made by taking a careful history, eliciting key symptoms, as well as performing a physical examination and limited diagnostic testing (4-6). IBS is categorized into four main subtypes based on the predominant bowel habit: IBS with constipation (IBC-C); IBS with diarrhea (IBS-D); IBS with mixed symptomology (IBS-M); and unclassified IBS (5).IBS imposes a significant burden to the health care system and to individuals.Direct medical costs attributed to IBS in the US, excluding prescription and over-thecounter medicines, were estimated at $1.5-$10 billion per year in 2005 (7). Patients with IBS enrolled in a large Health Maintenance Organization (HMO) had significantly more outpatient visits and incurred nearly 50% more in total costs than individuals without IBS (8). A retrospective case-control study from another large HMO reported that patients with IBS had significantly more diagnostic tests, imaging, and surgery compared with patients without a diagnosis of IBS (9). Significant variations in care across the United States related to the diagnosis and treatment of IBS also play a role in excessive health care costs (10). The burden of IBS on individuals can be measured in a number of ways. Studies have demonstrated consistently that IBS impairs work-related activities (e.g., lost work time, reduced productivity while at work) and also reduces quality of life (11,12). The development Ford et al.Page 3 of 91 of effective and efficient treatment strategies for IBS assumes considerable importance, therefore, not just for the individual sufferer, but for society at large.Given the clinical heterogeneity that is a hallmark of the disorder and the absence of a single effective therapy for all sufferers, available therapies tend to focus on predominant symptomatology at presentation (i.e., altered bowel habits, abdominal pain, or bloating) (4-6). Based on their purported mode of action, many pharmacological therapies for IBS developed in recent decades have been directed towards those with a particular bowel habit, whether diarrhea or constipation.However, treating IBS patients can be difficult as no validated treatment algorithm exists, not all patients respond to treatment, and patients with similar symptoms frequently respond to the same treatment differently. Fortunately, a variety of novel therapeutic strategies are being explored and new compounds have appeared since the last iteration of the ACG monograph on IBS (4). The goal of this document, therefore, is to provide an updated, evidence-based d...

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“…This accounts for approximately 50% of all deaths where access to health care is inadequate. 1 Medicinal plants as the backbone of traditional medicine have over the years been subjected to serious pharmacological investigations with a view to discovering new bioactive molecules. 2,3 Combretum is the largest genus of the Combretaceae family with about 370 species.…”

Section: Introductionmentioning

confidence: 99%

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

Oluyemi¹,

Samuel²,

Kählig³

et al. 2019

actapharm

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Combretum genus (Combretaceae) is used locally in the treatment of various diseases including malaria. Current study aimed to investigate the antiplasmodial activities of methanol extract of C. zenkeri in Plasmodium falciparum chloroquine sensitive (D10) and resistant (W2) strains and identify the bioactive principles. Repeated chromatographic separation was carried out on the chloroform fraction to afford the isolation of bioactive compounds which was characterized by application of spectroscopic techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR). Antiplasmodial activities of chloroform fraction (D10; IC 50 = 12.57±1.57 μg/mL and W2; IC 50 = 12.14±0.95 μg/mL) showed more activity than the n-butanol fraction (D10; IC 50 = 61.98±3.25 μg/mL and W2; IC 50 = 61.26±8.64 μg/mL). Phytochemical investigation of the extract afforded isolation of two triterpenes with antimalarial activities. This paper identified for the first time the antimalarial principles in C. zenkeri as ursolic and oleanolic acids; which justified the local use of the plant in the treatment of malaria.

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Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome

Cited by 47 publications

References 46 publications

Public Knowledge, Attitude, and Practice on Herbal Remedies Used During Pregnancy and Lactation in West Bank Palestine

Public Knowledge, Attitude, and Practice on Herbal Remedies Used During Pregnancy and Lactation in West Bank Palestine

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

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