Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: a double-blinded and randomized study

Yang, Gong; Zha, Qinglin; Li, Li; Liu, Yan; Yang, Bo; Liu, Liang; Lü, Aiping; Li, Yifan; Jiang, Miao; Wiebrecht, Axel

doi:10.1016/j.dza.2014.05.006

Cited by 12 publications

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Japan, Suzuki et al [20] have reported that Qing-Dai is clinically efficacious and safe in treating UC patients, although the data collected were retrospective in nature. Additional reports have been published on the Chinese herbal medicine Xilei-San [24][25][26] , Kui Jie Qing enema [27] and Fufangkushen colon-coated capsules [28] . These treatments are multiple herbal formulas that partly contain Qing-Dai.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto¹,

Naganuma²,

Kiyohara³

et al. 2016

Digestion

View full text Add to dashboard Cite

Background/Aims: Chinese herbal medicine Qing-Dai (also known as indigo naturalis) has been used to treat various inflammatory conditions. However, not much has been studied about the use of oral Qing-Dai in the treatment for ulcerative colitis (UC) patients. Studies exploring alternative treatments for UC are of considerable interest. In this study, we aimed at prospectively evaluating the safety and efficacy of Qing-Dai for UC patients. Methods: The open-label, prospective pilot study was conducted at Keio University Hospital. A total of 20 patients with moderate UC activity were enrolled. Oral Qing-Dai in capsule form was taken twice a day (daily dose, 2 g) for 8 weeks. Results: At week 8, the rates of clinical response, clinical remission, and mucosal healing were 72, 33, and 61%, respectively. The clinical and endoscopic scores, CRP levels, and fecal occult blood results were also significantly improved. We observed 2 patients with mild liver dysfunction; 1 patient discontinued due to infectious colitis and 1 patient discontinued due to mild nausea. Conclusion: This is the first prospective study indicating that oral Qing-Dai is effective for inducing remission in patients with moderate UC activity and can be tolerated. Thus, Qing-Dai may be considered an alternative treatment for patients, although further investigation is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto¹,

Naganuma²,

Kiyohara³

et al. 2016

Digestion

View full text Add to dashboard Cite

show abstract

“…Clinical trials were included if they had evaluated the healing of venous ulcers with the topical use of herbal medicines. Studies that evaluated ulcer healing with the use of herbal medicines in animals , ulcers with other etiologies , cost‐benefit and reporting cases were excluded .…”

Section: Methodsmentioning

confidence: 99%

The use of medicinal plants in venous ulcers: a systematic review with meta‐analysis

Freitas

Santos

Souza

et al. 2017

International Wound Journal

View full text Add to dashboard Cite

The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review. Of the included studies, 7 (100%) evaluated the reduction of the ulcer area, 4 (57·14%) evaluated reepithelisation, 2 (28·57%) evaluated bacterial flora and 1 (14·28%) evaluated the oxygen pressure and percutaneous carbon dioxide. The level of evidence rating indicated that five studies (71·42%) were rated at level 2 and two (28·57%) were rated at level 3. The quality assessment was performed using the Jadad scale, which is prevalent in the literature. The quality score of the Jadad questionnaire ranges from 0 to 5; here, the studies analysed had an average of 2·5. A meta-analysis was performed on two studies that analysed the effects of Mimosa tenuiflora hydrogel in the treatment of venous ulcer and included 42 patients with a mean age of 60·5 years and a mean duration of treatment of 10·5 weeks. Heterogeneity was assessed using I ; we obtained a high value of 84%. We concluded that, despite the efficacy of the incorporation of Ageratina pichinchensis into the gel, the hydrogel that incorporated M. tenuiflora appeared to be a promising candidate for the management of venous ulcers.

show abstract

“…For instance, in a double-blinded and randomized clinical trial, Fufangkushen enteric-coated capsule was proved to be similarly effective and safe in the treatment of active ulcerative colitis (UC) with TCM syndrome of damp-heat accumulation interior compared with a mesalamine enteric-coated tablet, and it even indicated preferable effect in the treatment of UC with inflamed area of the left hemicolon (Gong et al, 2011). In a prospective RCT, Tanreqing Injection was proved to be able to improve the TCM signs and symptoms in the patients with acute exacerbation of chronic obstructive pulmonary disease and TCM syndrome of retention of phlegm and heat in Fei (Lung) .…”

Section: Syndrome Differentiation and Modern Clinical Research In Tcmmentioning

confidence: 98%

Syndrome differentiation in modern research of traditional Chinese medicine

Jiang

Lü

Zhang

et al. 2012

Journal of Ethnopharmacology

Self Cite

317

192

View full text Add to dashboard Cite

a b s t r a c tSyndrome differentiation (Bian Zheng) in traditional Chinese medicine (TCM) is the comprehensive analysis of clinical information gained by the four main diagnostic TCM procedures: observation, listening, questioning, and pulse analysis, and it is used to guide the choice of treatment either by acupuncture and/or TCM herbal formulae, that is, Fufang. TCM syndrome differentiation can be used for further stratification of the patients' conditions with certain disease, identified by orthodox medical diagnosis, which could help the improvement of efficacy of the selected intervention. In modern TCM research it is possible to integrate syndrome differentiation with orthodox medical diagnosis leading to new scientific findings in overall medical diagnosis and treatment. In this review, the focus is to screen published evidence on the role of syndrome differentiation in modern TCM research with particular emphasis on basic and clinical research as well as, pharmacological evaluation of TCM herbal formulary for drug discovery.

show abstract

Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: a double-blinded and randomized study

Cited by 12 publications

References 1 publication

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

The use of medicinal plants in venous ulcers: a systematic review with meta‐analysis

Syndrome differentiation in modern research of traditional Chinese medicine

Contact Info

Product

Resources

About