Efficacy and Safety of Giant Condyloma Acuminatum with Monotherapy of Topical Traditional Chinese Medicine: Report of Eight Cases

Abstract

Background: Giant condyloma acuminatum (GCA), also called Buschke-Löwenstein tumor, presents as a verrucous infiltrating lesion and is caused by sexual transmission of human papilloma virus. The optimal treatment is controversial and there are no standard guidelines because of its rarity and frequent recurrence. It has a relatively high local recurrence rate. Objective: We here report eight patients (six men and two women) with GCA whose lesions were successfully treated topically with traditional Chinese medicine (TCM) preparations, paiteling. Methods and Materials: We administered topical TCM preparations to eight patients diagnosed with GCA who had refused surgery. The treatment process included three stages, their durations depending on the speed of resolution of the lesions and the results of visual inspection with acetic acid. Results: No significant complications occurred in any patient. The functional and esthetic outcomes were satisfactory. No recurrences were detected during follow-up. Conclusion:Topical treatment with TCM preparations may be a good alternative to surgery or other traditional methods for the treatment of GCA. This treatment has the advantages of being non-invasive, painless, and having a low risk of recurrence, and may be a useful adjunct to mainstream medical treatments.

A Case of Giant Perianal Condylomata Acuminata with IgA Nephropathy Treated Successfully by a Topical Chinese Medicine Preparation Paiteling

“…It is composed of many ingredients, including Java brucea fruit oil, folium isatidis, spreading hedyotis herb, sophora flavescens and cnidium fruit. 8 Folium isatidis has a broad-spectrum antibacterial and antiviral effect. Java brucea has high selectivity for infected https://doi.org/10.2147/CCID.S400677…”

“…It has been reported that topical use of traditional Chinese medicine preparation paiteling helps treat CA with satisfactory outcomes. 8 We report herein a case of an adult with giant CA around the anus and multiple condylomatous lesions on the penis, who also suffered from mixed hemorrhoid and IgA nephropathy meanwhile, successfully cured with external application of Chinese medicine preparation paiteling.…”