Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months

Ziesenitz, Victoria C.; Zutter, Andreas; Erb, Thomas O.; Anker, John van den

doi:10.1007/s40272-017-0235-3

Cited by 33 publications

(29 citation statements)

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“…Our results are similar to those of most but not all other studies and support the findings of a recent comprehensive review on the topic by Ziesenitz et al . [ 24 ] In Lesko and Mitchell a comparison of ibuprofen to acetaminophen for fever in older children, protocol violations led to 319 infants younger than six months receiving ibuprofen. None had serious adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Safety of ibuprofen in infants younger than six months: A retrospective cohort study

2018

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ObjectiveWe hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse effects than acetaminophen in infants younger than six months.MethodsWe created two partly overlapping retrospective cohorts of infants aged less than six months when California Medicaid first paid for ibuprofen or acetaminophen between 2004 and 2010. In the first cohort we compared the incidence rate ratio (RR) of GI and renal AE between those infants first prescribed ibuprofen before six months of age with those first prescribed ibuprofen after six months of age. In the second cohort we compared the RR of GI and renal AE between infants younger than six months prescribed ibuprofen (+/-acetaminophen) with those prescribed only acetaminophen.ResultsWe identified 41,669 prescriptions for ibuprofen and 176,991 prescriptions for acetaminophen in 180,333 eligible infants (median age 2.1 months). We did not observe higher RR of any AE in infants first prescribed ibuprofen before rather than after six months of age. Most infants prescribed ibuprofen were also prescribed acetaminophen. Any GI (adjusted (a)RR 1.25, 95% CI 1.13–1.38) and moderate or severe GI AE (aRR 1.24, 95% CI 1.09–1.40) were more common in infants younger than six months who were prescribed ibuprofen versus acetaminophen alone. Severe GI (aRR 0.63, 95% CI 0.27–1.45) and renal AE (aRR 1.84 95% CI 0.66–5.19) were not different between the ibuprofen (+/-acetaminophen) and acetaminophen-only groups.ConclusionsGI and renal AEs were not higher in infants younger than six months who were prescribed ibuprofen compared with those aged six to 12 months. AEs were increased in infants younger than six months who were prescribed ibuprofen compared with infants who were prescribed acetaminophen alone.

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Section: Discussionmentioning

confidence: 99%

Safety of ibuprofen in infants younger than six months: A retrospective cohort study

2018

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“…However, there are a limited number of available analgesic agents via IV route. There are many clinical studies showing the difference of effects of ibuprofen, paracetamol, and IV analgesics on airway spasms (24). There is no organ bath study that demonstrates the effects of the drugs on specific bronchial muscle tissue.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An <i>In Vitro</i> Study

Erdem¹,

Erel²,

Özkisacik³

et al. 2019

meandros

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Amaç: Bronkospazm post-operastif ve intraoperatif dönem boyunca karşılaşılabilen çok önemli bir komplikasyondur. Bu komplikasyon cerrahi, anestezi ve hastaya ait nedenlerle oluşabilmektedir. Post-operatif analjezi oluşturmak için intraoperatif dönemde rutinde pek çok analjezik tercih edilmektedir. Bizde bu çalışmada Öz Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats' bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats' bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to group 1, and ibuprofen to group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in group 2, and the relaxation response reached the baseline tonus in this group. Conclusion: Intraoperative analgesia is very important in preventing post-operative complications and ensuring patient comfort. In general, opioids and concomitant nonsteroidal anti-inflammatory or paracetamol group drugs are preferred intraoperatively for post-operative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm. AbstractORCID ID: orcid.org/0000-0002-9584-4200Ad dressforCor res pon den ce/Ya zış maAd re si: Erdem et al. Is NSAI Bronchospasm A Rescuer Analgesic? in vitro şartlarda bir bronkospazm modeli olarak supramaksimal tonuslü rat trakeasında intravenöz analjeziklerden ibuprofen ve parasetamolün etkilerini görmeyi amaçladık. Gereç ve Yöntemler: Çalışmamızda toplam 20 erkek rat kullanıldı. Ketamin anestezisi sonrası her ratın sol ana bronşları çıkarılarak Krebs solüsyonunda organ banyosuna asıldı. Dört rat bronşu asetilkolin ve atropine cevap alınamadığı için çalışma dışı bırakıldı. Canlılığı kanıtlanan rat bronşlarına (n=16) asetilkolin uygulanarak supramaksimal kontraksiyon oluşturuldu. Supramaksimal kontraksiyon oluşturulan rat bronşları randomize olarak ...

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“…There are many clinical studies showing the difference of effects of ibuprofen, paracetamol, and I.V. analgesics on airway spasms (24). There is no organ bath study that demonstrates the effects of the drugs on specific bronchial muscle tissue.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: an in Vitro Study

Erdem¹,

Erel²,

Özkisacik³

et al. 2019

meandros

View full text Add to dashboard Cite

Amaç: Bronkospazm postoperastif ve intraoperatif dönem boyunca karşılaşılabilen çok önemli bir komplikasyondur. Bu komplikasyon cerrahi, anestezi ve hastaya ait nedenlerle oluşabilmektedir. Postoperatif analjezi oluşturmak için intraoperatif dönemde rutinde pek çok analjezik tercih edilmektedir. Bizde bu çalışmada invitro şartlarda bir bronkospazm modeli olarak supramaksimal tonuslü rat trakeasında intravenöz analjeziklerden ibuprofen ve parasetamolün etkilerini görmeyi amaçladık. Objective: Bronchospasm is a very important complication that can be encountered during the postoperative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for postoperative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats' bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats' bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to Group 1, and ibuprofen to Group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in Group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in Group 2, and the relaxation response reached the baseline tonus in this group. Conclusion: Intraoperative analgesia is very important in preventing postoperative complications and ensuring patient comfort. In general, opioids and concomitant NSAI or paracetamol group drugs are preferred intraoperatively for postoperative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm.

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Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months

Cited by 33 publications

References 60 publications

Safety of ibuprofen in infants younger than six months: A retrospective cohort study

Safety of ibuprofen in infants younger than six months: A retrospective cohort study

The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An <i>In Vitro</i> Study

The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: an in Vitro Study

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