Efficacy and safety of imidacloprid/moxidectin spot-on solution and fenbendazole in the treatment of dogs naturally infected with Angiostrongylus vasorum (Baillet, 1866)

Willesen, Jakob L.; Kristensen, Annemarie T.; Jensen, A. L.; Heine, J.; Koch, J.

doi:10.1016/j.vetpar.2007.05.001

Cited by 91 publications

(89 citation statements)

References 15 publications

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“…An early diagnosis is essential to ensure anthelminthic treatment before the onset of pathological changes, which can be present before clinical signs, as previously shown (Schnyder et al 2009(Schnyder et al , 2010. Adequate anthelmintic treatments (Conboy 2004;Willesen et al 2007;Schnyder et al 2009) allow good prognosis for A. vasorum-affected dogs. Thus, the monthly use of macrocyclic lactones (Schnyder et al 2009) or routine screening of dogs for A. vasorum infection (Verzberger-Epshtein et al 2008;Schnyder et al 2011b) for prevention of clinical angiostrongylosis are already recommended in known endemic areas.…”

Section: Discussionmentioning

confidence: 97%

Serological Detection of Circulating Angiostrongylus vasorum Antigen- and Parasite-Specific Antibodies in Dogs from Poland

et al. 2013

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Dogs infected with Angiostrongylus vasorum, a potentially lethal parasite living in the heart and pulmonary arteries, may present severe respiratory and neurological sings and coagulopathies. Its occurrence is increasingly reported from various European countries, but little is known about its presence in Poland. In this first large-scale survey, 3,345 sera from polish dogs attending veterinary clinics in different parts of Poland for various reasons were collected and tested by an ELISA for the detection of circulating antigen of A. vasorum and by a separate ELISA detecting specific antibodies. A total of 0.51 % (n = 17, 95% Confidence Intervals, CI: 0.30-0.81 %) of the animals were positive in both ELISAs, while 0.78 % (n = 26, CI: 0.51-1.14 %) of the tested dogs were antigen-positive only and 1.29 % (n = 43, CI: 0.93-1.73 %) were positive for specific antibodies only. Regions with antigen-and antibody-positive animals were overlapping and distributed over the whole area of the country, with approximately one S110 Endopar asitEs third of positives close to the Baltic Sea, and a limited number of cases close to the German border. These results confirm the occurrence of A. vasorum in dogs originating from different parts of Poland. A. vasorum serology presents significant advantages (diagnosis before patency, single serum sample instead of repeated faecal samples, rapidity and affordability particularly in case of large number of samples), and it can be considered a valid alternative for diagnosis in individuals and in epidemiological studies.

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Section: Discussionmentioning

confidence: 97%

Serological Detection of Circulating Angiostrongylus vasorum Antigen- and Parasite-Specific Antibodies in Dogs from Poland

et al. 2013

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“…The red fox (Vulpes vulpes) could be responsible for the introduction and spreading of the parasite as recently described in The Netherlands [26]. Clearly, additional studies in both final and intermediate hosts as well as proper information of practitioners regarding diagnosis and treatments are needed taking into account that highly effective drugs such as fenbendazole [27], moxidectin [27,28] and milbemycin oxime [29,30] are widely available.…”

Section: Discussionmentioning

confidence: 98%

First report of a fatal autochthonous canine Angiostrongylus vasorum infection in Belgium

Jolly

Poncelet²,

Lempereur

et al. 2015

Parasitology International

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Canine angiostrongylosis is considered as an emergent disease in Europe and Canada. A fatal case of Angiostrongylus vasorum infection is described in a four and a half month old puppy born in Belgium. The dog was presented with marked neurological disorders, body weight loss, a profound weakness and mild respiratory signs. The dog was given antibiotics and mucolytic compounds with very little improvement and consequently was referred to a specialist for additional examinations. As the general condition of the dog was rapidly declining, the animal was euthanized shortly after on its owners' request and a necropsy was carried out. Extensive gross pulmonary lesions were observed and histopathological examination revealed the presence of numerous larvae with morphology compatible with A. vasorum. Larvae were also found in the product of a bronchoalveolar lavage but fecal material was not examined. The presence of A. vasorum circulating serum antigen was demonstrated through ELISA; additionally an A. vasorum specific PCR was performed on brain material and yielded a positive result. This case confirms that the clinical diagnosis of canine angiostrongylosis can be very challenging especially when respiratory signs are absent or very mild such in the present case. This is the first reported case of canine angiostrongylosis in Belgium.

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“…The major clinical impact of A. vasorum infections in dogs means that it is of essential importance to increase awareness of the occurrence of A. vasorum among clinicians and dog owners, particularly in previously unreported areas bordering endemic regions, with the aim of preventing fatal cases of canine angiostrongylosis. Newly developed, rapid and easy-to-use commercial devices for use in veterinary practices ) and adequate metaphylactic and prophylactic anthelmintic treatments (Conboy 2001;Willesen et al 2007;Schnyder et al 2009) allow early diagnosis and consequently a good prognosis for dogs affected by A. vasorum.…”

Section: Discussionmentioning

confidence: 99%

Combined Serological Detection of Circulating Angiostrongylus vasorum Antigen and Parasite-specific Antibodies in Dogs from Hungary

Schnyder

Schaper

Lukács³

et al. 2015

Parasitol Res

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The occurrence of the nematode Angiostrongylus vasorum, also known as the French heartworm, is increasingly being reported from various European countries. The adults of this parasite species live in the pulmonary arteries and right cardiac ventricle of wild canids and domestic dogs. Larval stages and eggs in the lungs induce inflammatory verminous pneumonia, causing severe respiratory disease in dogs. Furthermore, haematological and neurological signs and even death may occur. In Hungary, A. vasorum has been identified in red foxes, golden jackals and in two dogs and some slugs. In this first large-scale survey, 1247 sera from pet dogs were collected and tested by an ELISA for the detection of circulating antigen of A. vasorum and by a separate ELISA to detect specific antibodies against the parasite. A total of 1.36% (n = 17, 95 % confidence intervals, CI: 0.80 -2.17 %) of the animals were positive in both ELISAs, while 1.76 % (n = 22, CI: 1.11 -2.66 %) of the tested dogs were antigen-positive only and 2.73 % (n = 34, CI: 1.90 -3.79 %) were positive for specific antibodies only. Regions with antigen-and antibodypositive animals overlapped and were distributed over nearly the whole sampled areas of the country. A considerable number of cases was observed in Budapest and also in the southern part of the country bordering Croatia, while in the most eastern part bordering Ukraine no positive samples were detected. These results confirm the endemic occurrence of A. vasorum in dogs originating from different parts of Hungary and the significant advantages of A. vasorum serology in epidemiological studies. S146EndoparasitEs

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Efficacy and safety of imidacloprid/moxidectin spot-on solution and fenbendazole in the treatment of dogs naturally infected with Angiostrongylus vasorum (Baillet, 1866)

Cited by 91 publications

References 15 publications

Serological Detection of Circulating Angiostrongylus vasorum Antigen- and Parasite-Specific Antibodies in Dogs from Poland

Serological Detection of Circulating Angiostrongylus vasorum Antigen- and Parasite-Specific Antibodies in Dogs from Poland

First report of a fatal autochthonous canine Angiostrongylus vasorum infection in Belgium

Combined Serological Detection of Circulating Angiostrongylus vasorum Antigen and Parasite-specific Antibodies in Dogs from Hungary

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