Efficacy and safety of manuka honey for dry eye

Hu, Jindong; Kong, Lingwen; Zhu, Sixing; Ju, Mohan; Zhang, Qianfu

doi:10.1080/08164622.2022.2106779

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…All MRSA-infected mice recuperated after IV treatment with MH, and a substantial reduction of bacterial load was seen in K. pneumoniae subjects (Qamar et al, 2018). Other more obscure yet interesting uses include treatment of dry eye (Hu et al, 2022), dental ailments (Al-Kubaisi and Al-Ghurabi, 2023;Opsǐvačet al, 2023), and sinus rinses for cystic fibrosis patients (Roberts et al, 2022). To improve MH's delivery to problematic sites of infection, circumvent its dilution, and improve contact time, other studies have explored the use of agents such as artificial liposomes and micelles for the in vivo delivery of MH (Maddocks and Jenkins, 2013;Patra et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Combinatorial efficacy of Manuka honey and antibiotics in the in vitro control of staphylococci and their small colony variants

Liang,

Adeleye,

Onyango

2023

Front. Cell. Infect. Microbiol.

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IntroductionStaphylococci are among the list of problematic bacteria contributing to the global antibiotic resistance (ABR) crisis. Their ability to adopt the small colony variant (SCV) phenotype, induced by prolonged antibiotic chemotherapy, complicates staphylococcal infection control options. Novel and alternative approaches are needed to tackle staphylococcal infections and curb ABR. Manuka honey (MH), a non-antibiotic alternative is recognized for its unique antibacterial activity based on its methylglyoxal (MGO) component.MethodsIn this study, MH (MGO 830+) was tested in combination with gentamicin (GEN), rifampicin (RIF), or vancomycin (VA) against staphylococcal wildtype (WT) and SCVs. To our knowledge, there are no current studies in the literature documenting the effects of MH on staphylococcal SCVs. While Staphylococcus aureus is well-studied for its international ABR burden, limited data exists demonstrating the effects of MH on S. epidermidis and S. lugdunensis whose pathogenic relevance and contribution to ABR is also rising.Results & discussionThe three staphylococci were most susceptible to RIF (0.06-0.24 μg/ml), then GEN (0.12-0.49 μg/ml), and lastly VA (0.49-0.96 μg/ml). The MICs of MH were 7%, 7-8%, and 6-7% (w/v), respectively. Fractional inhibitory concentration (FIC) evaluations showed that the combined MH + antibiotic effect was either additive (FICI 1-2), or partially synergistic (FICI >0.5-1). While all three antibiotics induced SCVs in vitro, stable SCVs were observed in GEN treatments only. The addition of MH to these GEN-SCV-induction analyses resulted in complete suppression of SCVs (p<0.001) in all three staphylococci, suggesting that MH’s antibacterial properties interfered with GEN’s SCV induction mechanisms. Moreover, the addition of MH to growth cultures of recovered stable SCVs resulted in the inhibition of SCV growth by at least 99%, indicating MH’s ability to prevent subsequent SCV growth. These in vitro analyses demonstrated MH’s broad-spectrum capabilities not only in improving WT staphylococci susceptibility to the three antibiotics, but also mitigated the development and subsequent growth of their SCV phenotypes. MH in combination with antibiotics has the potential to not only resensitize staphylococci to antibiotics and consequently require less antibiotic usage, but in instances where prolonged chemotherapy is employed, the development and growth of SCVs would be hampered, providing a better clinical outcome, all of which mitigate ABR.

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Section: Discussionmentioning

confidence: 99%

Combinatorial efficacy of Manuka honey and antibiotics in the in vitro control of staphylococci and their small colony variants

Liang,

Adeleye,

Onyango

2023

Front. Cell. Infect. Microbiol.

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“…Continuous supplementation of omega-3 fatty acids for 3 months reduced tear osmolality and increased tear film stability while reducing IL-17A levels ( 125 ). The ratio of ω-3 to ω-6 fatty acids determines whether inflammation occurs.…”

Section: Anti-inflammatory Treatment Of Dry Eyementioning

confidence: 99%

Inflammation mechanism and anti-inflammatory therapy of dry eye

Chu,

Wang,

Zhou

2024

Front. Med.

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Dry eye is a widespread chronic inflammatory disease that causes fatigue, tingling, burning, and other symptoms. Dry eye is attributed to rheumatic diseases, diabetes, hormone disorders, and contact lenses, which activate inflammatory pathways: mitogen-activated protein kinases (MAPK) and nuclear factor-B (NF-κB), promote macrophage inflammatory cell and T cell activation, and inflammation factors. Clinicians use a combination of anti-inflammatory drugs to manage different symptoms of dry eye; some of these anti-inflammatory drugs are being developed. This review introduces the dry eye inflammation mechanisms and the involved inflammatory factors. We also elucidate the anti-inflammatory drug mechanism and the detection limits.

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“…Beyond wound care, MH formulations have been investigated for diverse clinical applications. The non-wound-associated applications of MH can be grouped into a few main types, including the treatment of ophthalmic conditions, such as dry eye, and blepharitis ( Hu et al., 2022 ); the management of diabetic foot ulcers ( Gill et al., 2019 ; Nair et al., 2020 ), in oral and gastrointestinal applications such as chronic periodontitis, oral mucositis, functional dyspepsia, acute pouchitis, and cold sores ( Al-Kubaisi and Al-Ghurabi, 2023 ; Onuoha et al., 2023 ; Opšivač et al., 2023 ); for respiratory disorders like cystic fibrosis, chronic rhinosinusitis, and esophagitis ( Lee et al., 2021 ; Roberts et al., 2022 ), and in the treatment of ear infections such as acute otitis, to mention a few (see Supplementary Table S2 for a complete list). In addition, although none of the clinical trials specified the cause of these conditions, we assessed MH’s clinical applications by possible infectious aetiology.…”

Section: Clinical Application Of Mhmentioning

confidence: 99%

Manuka honey as a non-antibiotic alternative against Staphylococcus spp. and their small colony variant (SCVs) phenotypes

Onyango,

Liang

2024

Front. Cell. Infect. Microbiol.

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The antibiotic resistance (ABR) crisis is an urgent global health priority. Staphylococci are among the problematic bacteria contributing to this emergency owing to their recalcitrance to many clinically important antibiotics. Staphylococcal pathogenesis is further complicated by the presence of small colony variants (SCVs), a bacterial subpopulation displaying atypical characteristics including retarded growth, prolific biofilm formation, heightened antibiotic tolerance, and enhanced intracellular persistence. These capabilities severely impede current chemotherapeutics, resulting in chronic infections, poor patient outcomes, and significant economic burden. Tackling ABR requires alternative measures beyond the conventional options that have dominated treatment regimens over the past 8 decades. Non-antibiotic therapies are gaining interest in this arena, including the use of honey, which despite having ancient therapeutic roots has now been reimagined as an alternative treatment beyond just traditional topical use, to include the treatment of an array of difficult-to-treat staphylococcal infections. This literature review focused on Manuka honey (MH) and its efficacy as an anti-staphylococcal treatment. We summarized the studies that have used this product and the technologies employed to study the antibacterial mechanisms that render MH a suitable agent for the management of problematic staphylococcal infections, including those involving staphylococcal SCVs. We also discussed the status of staphylococcal resistance development to MH and other factors that may impact its efficacy as an alternative therapy to help combat ABR.

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Efficacy and safety of manuka honey for dry eye

Abstract: Title1 Identify the report as a systematic review, meta-analysis, or both.

Cited by 7 publications

References 54 publications

Combinatorial efficacy of Manuka honey and antibiotics in the in vitro control of staphylococci and their small colony variants

Combinatorial efficacy of Manuka honey and antibiotics in the in vitro control of staphylococci and their small colony variants

Inflammation mechanism and anti-inflammatory therapy of dry eye

Manuka honey as a non-antibiotic alternative against Staphylococcus spp. and their small colony variant (SCVs) phenotypes

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