Efficacy and safety of oral minoxidil in female androgenetic alopecia

Vastarella, Maria; Cantelli, Mariateresa; Patrì, Angela; Annunziata, Maria Carmela; Nappa, Paola; Fabbrocini, Gabriella

doi:10.1111/dth.14234

Cited by 32 publications

(46 citation statements)

References 6 publications

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“…Panchaprateep and Lueangarun [39] 5 mg 6 30 Significant increase in total hair counts from baseline notice Assessment of the vertex area revealed 100% improvement with 43% of patients showing excellent improvement Vastarella et al [40] 1.25 mg 6 12 58% had marked improvement while 42% had mild improvement Jha et al [41] 1.25 mg 6 32 Marked improvement -43.3% Mid improvement -40.6%…”

Section: N* Resultsmentioning

confidence: 99%

“…ese studies used doses ranging from 0.25 mg to 2.5 mg while studies with higher doses were associated with more frequent side effects [Table 3]. [25,[27][28][29][38][39][40][41]45,47] Contraindications to OM include pheochromocytoma or previous hypersensitivity reactions to ingredients, hypotension, cardiac comorbidities, and pregnancy or breast feeding. [20] Considered as Pregnancy Category-C drug, rare reports of fetal malformations have been reported.…”

Section: A=47 B=48mentioning

confidence: 99%

“…2 Case 1: No adverse effects noticed after 2 years of therapy Case 2: No adverse effects noticed after 18 months of therapy Cranwell and Sinclair [29] 0.5 mg 1 No adverse effects mentioned Vano-Galvan et al [22] Males: 2.5 mg Females: 1 mg 51 Adverse effects-mild-37% Hypertrichosis-27.5%, Postural hypotension-5.9%, Tachycardia-3.9%, Weight gain-1.9% Olamiju and Craiglow [38] 2.5 mg 6 None-Treatment was well tolerated and without any adverse effects Beach et al [45] 1.25 51 Lightheadedness-4, Palpitations-2, Ankle edema-1, Hypertrichosis-22, Skin Urticaria-1, Other Paresthesia-1 Sanabria et al [47] 0.5-5 mg 435 Hypertrichosis-54%, Headache-10%, Insomnia-7%, Edema-9%, Dizziness-7%, Palpitations-4%, Facial edema-1% Panchaprateep and Lueangarun [39] 5 mg 30 Hypertrichsosis-93%, ECG findings-20%-premature ventricular contraction (occasional), T-wave inversion, Pedal edema-10% Vastarella et al [40] 1.25 mg…”

Section: Study Dose N* Adverse Effectsmentioning

confidence: 99%

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Role of low dose oral minoxidil in the treatment of hair loss: A review

Alexander

Mysore²,

Hirevenkangoudar

2021

CSDM

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Low-dose oral minoxidil (OM) has increasingly been used by many doctors around the world as a treatment option for hair loss. Sufficient data regarding its effect and side effect profile are lacking. An online search was done on PUBMED and GOOGLE SCHOLAR for articles that used OM as a treatment option for hair loss. Doses ranging from 0.25 to 5 mg have been used for treatment in various studies. Good compliance and tolerability have been noticed with low-dose OM therapy. Adverse effects are few and are mild with hypertrichosis being the most common adverse effect in a majority of the studies, the risk of which increases with an increase in dosage of the drug.

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Section: N* Resultsmentioning

confidence: 99%

Section: A=47 B=48mentioning

confidence: 99%

Section: Study Dose N* Adverse Effectsmentioning

confidence: 99%

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Role of low dose oral minoxidil in the treatment of hair loss: A review

Alexander

Mysore²,

Hirevenkangoudar

2021

CSDM

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“…In a retrospective study published by Vastarella et al . which included 12 patients with AGA treated with oral minoxidil, starting at 0.50 mg daily for 3 months and afterwards increasing the dose to 1.5–2 mg daily, an overall 38% and 23% improvement of hair density in the frontal and vertex area respectively was observed after 24 weeks 10 . The most common adverse events found were mild hypertrichosis in 25%, mild postural dizziness in 8.3% and mild peripheral oedema in 25%.…”

Section: Methodsmentioning

confidence: 97%

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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Topical minoxidil has been used for many years as treatment for different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cosmesis, cost and side‐effects. During the last few years, low‐dose oral minoxidil has proven to be an alternative for patients with alopecia. We performed a literature search including all the articles that used oral minoxidil as a primary treatment in various hair diseases in order to evaluate the efficacy and safety of low‐dose oral minoxidil as an alternative to topical minoxidil. Androgenetic alopecia was the most common studied condition, but others included telogen effluvium, tractional alopecia, postchemotherapy‐induced alopecia, monilethrix, loose anagen hair syndrome, alopecia areata and scarring alopecias (frontal fibrosing alopecia and lichen planopilaris). Larger randomized comparative studies including standardized objective measurements should be done in order to clarify the best treatment protocol, including dosage and treatment duration. Oral minoxidil has proven to be a successful and well‐tolerated alternative for patients with hair loss, including those with poor adherence to other therapies. Different dosing regimens have been utilized in scarring and non‐scarring alopecia, varying from 0.25 to 5 mg daily. Higher doses have not been studied in men or women. Available literature suggests women require lower doses, from 0.25 to 2.5 mg daily, while men require higher doses for maximal efficacy, from 1.25 to 5 mg a day.

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“…In this last case, the authors did not define whether the relationship was causal or casual. 5,14 In a previous case report of frontal edema, Güngör et al implied the topical minoxidil application after mesotherapy caused the adverse event, since mesotherapy with biotin, when done alone, was not associated with any side effects. 15 In our patients, the edema mostly arose in the first two sessions and lasted between 1 and 4 days, with a favorable outcome after a local cold compress.…”

mentioning

confidence: 99%

Frontal edema due to mesotherapy for androgenetic alopecia: A case series

Melo

Saceda‐Corralo

Tosti

et al. 2021

Dermatologic Therapy

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Androgenetic alopecia (AGA) is the most common form of non-cicatricial alopecia in both genders. Currently approved drugs for the treatment of AGA include topical minoxidil in women and topical minoxidil and oral finasteride in men. Other routes of administration of approved drugs have been proposed to enhance therapeutic results for AGA, including intradermal injections, known as mesotherapy. Mesotherapy-or intradermotherapy-is a non-surgical procedure, consisting of multiple intradermal injections of pharmacological substances diluted in small doses. Although minimally invasive, mesotherapy may be related to mild side effects like burning, erythema and headaches, as a few reports indicate. Among the most serious adverse events, subcutaneous necrosis, scalp abscesses, and angioedema have been described. This multicenter retrospective, descriptive study aims to report 14 cases of frontal edema resulting from mesotherapy for AGA treatment. In our patients, the edema mostly arose in the first two sessions and lasted between 1 and 4 days, with a favorable outcome after a local cold compress. In all our cases of edema, lidocaine was the anesthetic used. Minoxidil and dutasteride might also play a role as causative agents. To the best of our knowledge, this is the largest case series focused on frontal edema after mesotherapy for AGA and gives clinicians helpful information for when performing this technique. Dermatologists should already consider and be conscious of this possible mesotherapy side effect, as it can be remarkably disruptive to affected patients.

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Efficacy and safety of oral minoxidil in female androgenetic alopecia

Cited by 32 publications

References 6 publications

Role of low dose oral minoxidil in the treatment of hair loss: A review

Role of low dose oral minoxidil in the treatment of hair loss: A review

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Frontal edema due to mesotherapy for androgenetic alopecia: A case series

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