Role of low dose oral minoxidil in the treatment of hair loss: A review

Alexander, Sajin; Mysore, Venkataram; Hirevenkangoudar, Ashwini L.

doi:10.25259/csdm_29_2021

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…A multicenter retrospective analysis done by Feaster et al 18 studied 0.625–2.5 mg oral minoxidil for 1 year period in 105 patients of telogen effluvium and male androgenic alopecia patients with marked improvement and stabilization of the disease process. Similar findings were noted by Sinclair et al, 19 albeit hypertrichosis and cardiac side effects contributed to the discontinuation of the drug in few patients.…”

Section: Chronic Telogen Effluviumsupporting

confidence: 87%

Comprehensive review of oral minoxidil in alopecia

Modha

Pathania

2022

J of Cosmetic Dermatology

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Background: There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long-way finding its use from topical formulations to systemic at lower dose in different alopecia.Objective: The objective of this article is to discuss various conditions in alopecia where oral minoxidil has found its role.Methods: A comprehensive literature search was performed relating to oral minoxidil role in various alopecia. Various clinical trials, case series, and case reports were searched on PubMed and Google Scholar. The references of available studies were also reviewed to collect the additional resources. Available data from various studies and case reports were collected and consolidated to provide a concise overview of oral minoxidil indications in various alopecia. Results:Oral minoxidil has been used in various non-scarring and scarring alopecia at a lower dosage with less side effects and with promising results. Androgenetic alopecia and female pattern hair loss were the two conditions where it has been used more commonly than other alopecia, providing a ray of hope along with overcoming the issues related to topical formulations and compliance.

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Section: Chronic Telogen Effluviumsupporting

confidence: 87%

Comprehensive review of oral minoxidil in alopecia

Modha

Pathania

2022

J of Cosmetic Dermatology

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Role of oral minoxidil in the treatment of androgenetic alopecia

Lakshmi,

Sathvika

2024

CSDM

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Patterned hair loss is the most common cause of alopecia, typically presenting with progressive thinning, miniaturization, and loss of hair at classical topography depending on the sex of the patient. In the 1970s, Minoxidil was used to treat severe refractory hypertension due to its vasodilator properties. It became popular after its coincidental finding on the promotion of hair growth and stimulation of new hair production. In 1988, the Food and Drug Administration approved topical minoxidil (TM) 2% for the treatment of male androgenetic alopecia and in 1992, for female pattern hair loss. It is also used as an off-label treatment for other hair loss conditions such as telogen effluvium and alopecia areata. However, there are frequent reports of TM-induced contact dermatitis and its reversible effect, which has reduced compliance in the patients and resulted in a poor outcome. Hence, they have studied using low-dose oral minoxidil (LDOM), which showed good efficacy and safety profile in the treatment of patterned hair loss along with avoidance of high-risk adverse cardiac effects that resulted due to doses used for hypertension. The added advantages of LDOM over topical formulation are good compliance, cost savings, effective in people with low hair follicle sulfotransferase activity, and the possibility of cotherapy with other topical or oral medications.

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Role of low dose oral minoxidil in the treatment of hair loss: A review

Cited by 2 publications

References 48 publications

Comprehensive review of oral minoxidil in alopecia

Comprehensive review of oral minoxidil in alopecia

Role of oral minoxidil in the treatment of androgenetic alopecia

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